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The styrene–maleic acid copolymer: a versatile tool in membrane research
Open accessAbstract
A new and promising tool in membrane research is the detergent-free solubilization of membrane proteins by styrene-maleic acid copolymers (SMAs). These amphipathic molecules are able to solubilize lipid bilayers in the form of nanodiscs that are bounded by the polymer. Thus, membrane proteins can be directly extracted from cells in a water-soluble form while conserving a patch of native membrane around them. In this review article, we briefly discuss current methods of membrane protein solubilization and stabilization. We then zoom in on SMAs, describe their physico-chemical properties, and discuss their membrane-solubilizing effect. This is followed by an overview of studies in which SMA has been used to isolate and investigate membrane proteins. Finally, potential future applications of the methodology are discussed for structural and functional studies on membrane proteins in a near-native environment and for characterizing protein-lipid and protein-protein interactions.
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Frauenfeld, J., Gumbart, J., Sluis, E. O. V. D., Funes, S., Gartmann, M., Beatrix, B., Mielke, T., Berninghausen, O., Becker, T., Schulten, K., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2026 · Cited by 298
Cited by
Nanodiscs for structural and functional studies of membrane proteins
Denisov, I. G., & Sligar, S. G. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3195 · Cited by 522
Emerging Diversity in Lipid–Protein Interactions
Corradi, V., Sejdiu, B. I., Mesa-Galloso, H., Abdizadeh, H., Noskov, S. Y., Marrink, S. J., & Tieleman, D. P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00451 · Cited by 459
Cryo‐EM structure of the octameric pore of Clostridium perfringens β‐toxin
Bruggisser, J., Iacovache, I., Musson, S. C., Degiacomi, M. T., Posthaus, H., & Zuber, B. (2022) · The EMBO Reports · doi:10.15252/embr.202254856 · Cited by 13
mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations
Holmes, A. O. M., Goldman, A., & Kalli, A. C. (2022) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1010578 · Cited by 3
Metadata
- Authors
- Dörr, J. M., Scheidelaar, S., Koorengevel, M. C., Dominguez, J. J., Schäfer, M., van Walree, C. A., & Killian, J. A.
- Venue
- European Biophysics Journal
- Published
- 2015-12-06
- Volume
- 45
- Issue
- 1
- Pages
- 3-21
- ISSN
- 0175-7571 (ISSN-L)
- 1432-1017
- OpenAlex
- W2195989424
- Cited by
- 405
- References
- 2
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dörr, J. M., Scheidelaar, S., Koorengevel, M. C., Dominguez, J. J., Schäfer, M., van Walree, C. A., & Killian, J. A. (2016). The styrene–maleic acid copolymer: a versatile tool in membrane research. European Biophysics Journal. https://doi.org/10.1007/s00249-015-1093-y
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