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Cited by 17vaccines and immunoinformatics approachesImmunotherapy and Immune ResponsesT-cell and B-cell Immunology

Structure and function of the non-classical major histocompatibility complex molecule MR1

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Krovi, S. Harsha, Gapin, Laurent·2016·Immunogenetics
DOI 10.1007/s00251-016-0939-5PMC PMC5091073
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Abstract

Polymorphic major histocompatibility complex (MHC) molecules play a central role in the vertebrate adaptive immune system. By presenting short peptides derived from pathogen-derived proteins, these "classical" MHC molecules can alert the T cell branch of the immune system of infected cells and clear the pathogen. There exist other "non-classical" MHC molecules, which while similar in structure to classical MHC proteins, are contrasted by their limited polymorphism. While the functions of many class Ib MHC molecules have still to be elucidated, the nature and diversity of antigens (if any) that some of them might present to the immune system is expected to be more restricted and might function as another approach to distinguish self from non-self. The MHC-related 1 (MR1) molecule is a member of this family of non-classical MHC proteins. It was recently shown to present unique antigens in the form of vitamin metabolites found in certain microbes. MR1 is strongly conserved genetically, structurally, and functionally through mammalian evolution, indicating its necessity in ensuring an effective immune system for members of this class. Although MR1 will be celebrating 21 years this year since its discovery, most of our understanding of how this molecule functions has only been uncovered in the past decade. Herein, we discuss where MR1 is expressed, how it selectively is able to bind to its appropriate antigens and how it, then, is able to specifically activate a distinct population of T cells.

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Cited by

Sorted by citations

Authors
Krovi, S. H., & Gapin, L.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Gapin, Laurent
ORCID
Venue
Immunogenetics
Publisher
Springer Science and Business Media LLC
Published
2016-07-22
Volume
68
Issue
8
Pages
549-559
ISSN
  • 0093-7711 (ISSN-L)
  • 1432-1211
DOI
10.1007/s00251-016-0939-5
PMC
PMC5091073
OpenAlex
W2484151711
Cited by
17
References
2
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1
FWCI
0.09
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (unspecified)
Locations
  • Immunogenetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (AI103736)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
MR1, antigen presentation, T cell activation, antigen specificity, MHC polymorphism, self versus non-self recognition
MeSH terms
Genes, MHC Class I, Humans, Protein Conformation, Histocompatibility Antigens Class I, Minor Histocompatibility Antigens

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