Bacteria as vitamin suppliers to their host: A gut microbiota perspective
Open accessAbstract
Food-related lactic acid bacteria (LAB) as well as human gut commensals such as bifidobacteria can de novo synthesize and supply vitamins. This is important since humans lack the biosynthetic capacity for most vitamins and these must thus be provided exogenously. Although vitamins are present in a variety of foods, deficiencies still occur, mainly due to malnutrition as a result of insufficient food intake and because of poor eating habits. Fermented milks with high levels of B-group vitamins (such as folate and riboflavin) can be produced by LAB-promoted and possibly bifidobacteria-promoted biosynthesis. Moreover, certain strains of LAB produce the complex vitamin cobalamin (or vitamin B12). In this review, fermented foods with elevated levels of B-group vitamins produced by LAB used as starter cultures will be covered. In addition, genetic abilities for vitamin biosynthesis by selected human gut commensals will be discussed.
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Some bacteria in the gut microbiota, lactic acid bacteria and bifidobacteria, can produce vitamins, including vitamin B12.
“It is well established that some bacteria in the gut microbiota, lactic acid bacteria (LAB) and bifidobacteria, can produce vitamins, including vitamin B12.”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [123]
In the oral cavity, there are no observations of bacteria producing vitamins.
“However, in the oral cavity, at present, there are no such observations [123].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [123]
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Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00047 · Cited by 713 · see citing works
Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health
Parker, A., Fonseca, S., & Carding, S. R. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1638722 · Cited by 722 · see citing works
“coli; B9 (folic acid) by Bifidobacterium, Lactococcus lactis and Streptococcus thermophilus; and B12 (cobalamin) by Lactobacillus reuteri and Propionibacterium freudenreichii.(80) The uptake of microbe-derived vitamins occurs predominantly in the colon, in contrast to dietary vitamins, which are absorbed in the small…”
BackgroundSo, D., Whelan, K., Rossi, M., Morrison, M., Holtmann, G., Kelly, J. T., Shanahan, E. R., Staudacher, H. M., & Campbell, K. L. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy041 · Cited by 683 · see citing works
“vitamins (4) and interaction with the immune system (5, 6).”
BackgroundPessemier, B. D., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021) · Microorganisms · doi:10.3390/microorganisms9020353 · Cited by 661 · see citing works
“Many of these microorganisms are essential for metabolic and immune function, as they metabolize indigestible complex polysaccharides into essential nutrients such as vitamin K and B12, butyrate, and propionate [51,52].”
BackgroundInteraction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review
Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0852-y · Cited by 599 · see citing works
“A number of other B-group vitamins are synthesized by members of the gut microbiota, such as thiamine, riboflavin, niacin, pantothenic acid, pyridoxine, biotin and vitamin B12 [145, 149].”
BackgroundInfluentialClavijo, V., & Vives, M. J. (2017) · Poultry Science · doi:10.3382/ps/pex359 · Cited by 591 · see citing works
“2000) and vitamins (LeBlanc et al., 2013), though most of the proteins and vitamins produced by these bacteria are lost during excretion, as most intestinal bacteria are found in the cecum and this organ is unable to digest or absorb proteins (Vispo and Karasov, 1997).”
BackgroundKristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561 · see citing works
“The human gut microbiota refers to the microbes that reside inside the gut and partake in several functions beneficial to the host including fermentation of otherwise indigestible dietary fibers and other food items [1], synthesis of vitamins and amino acids [2], prevention of pathogen colonization [3], maturation and…”
BackgroundSpecialized metabolites from the microbiome in health and disease
Sharon, G., Garg, N., Debelius, J., Knight, R., Dorrestein, P. C., & Mazmanian, S. K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.016 · Cited by 544 · see citing works
The hologenome concept of evolution after 10 years
ROSENBERG, E. B., & Zilber‐Rosenberg, I. (2018) · Microbiome · doi:10.1186/s40168-018-0457-9 · Cited by 532 · see citing works
Lazăr, V., Diţu, L.-M., Pîrcălăbioru, G. G., Gheorghe, I., Curuțiu, C., Holban, A. M., Picu, A. A., Petcu, L. M., & Chifiriuc, M. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01830 · Cited by 536 · see citing works
Role of the gut microbiota in human nutrition and metabolism
Ramakrishna, B. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12294 · Cited by 505 · see citing works
Zhang, L., & Davies, S. S. (2016) · Genome Medicine · doi:10.1186/s13073-016-0296-x · Cited by 499 · see citing works
“Essential roles for several microbial metabolic pathways in host physiology have been long established, including in the production of vitamin K, the production of water-soluble B vitamins including biotin, folates, nicotinic acid, pyridoxine, riboflavin, cobalamin and panthotenic acid, the degradation of dietary oxal…”
BackgroundFeeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works
Celi, P., Cowieson, A. J., Fru-Nji, F., Steinert, R. E., Kluenter, A., & Verlhac-Trichet, V. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.09.012 · Cited by 486 · see citing works
Fermentation of plant-based milk alternatives for improved flavour and nutritional value
Tangyu, M., Muller, J. A., Bolten, C. J., & Wittmann, C. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10175-9 · Cited by 476 · see citing works
Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 498 · see citing works
“and propionate).(79,80) For example, butyrate wanes the intestinal barrier permeability and enhances epithelial barrier integrity.”
BackgroundAsnicar, F., Manara, S., Zolfo, M., Truong, D. T., Scholz, M., Armanini, F., Ferretti, P., Gorfer, V., Pedrotti, A., Tett, A., et al. (2017) · mSystems · doi:10.1128/msystems.00164-16 · Cited by 445 · see citing works
“Mucin utilization, specifically by infant gut microbial communities, is reflective of the higher abundance of mucin-degrading bifidobacteria observed from the taxonomic analyses described above (12, 59–61), whereas increased folate biosynthesis (12, 59, 60, 62) and decreased starch degradation (5) have been purported…”
BackgroundGut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health
Vernocchi, P., Del Chierico, F., & Putignani, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01144 · Cited by 426 · see citing works
“Several organic acids result from bacterial metabolism of dietary polyphenols or unassimilated AAs or carbohydrates (Lord and Bralley, 2008).”
BackgroundInfluentialHow nutrition and the maternal microbiota shape the neonatal immune system
Macpherson, A. J., de Agüero, M. G., & Ganal-Vonarburg, S. C. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.58 · Cited by 378 · see citing works
Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 420 · see citing works
Precision Nutrition and the Microbiome, Part I: Current State of the Science
Mills, S., Stanton, C., Lane, J. A., Smith, G., & Ross, R. P. (2019) · Nutrients · doi:10.3390/nu11040923 · Cited by 406 · see citing works
Ticinesi, A., Lauretani, F., Milani, C., Nouvenne, A., Tana, C., Del Rio, D., Maggio, M., Ventura, M., & Meschi, T. (2017) · Nutrients · doi:10.3390/nu9121303 · Cited by 401 · see citing works
“For example, a healthy gut microbiota is able to produce significant amounts of folate and vitamin B12 [106], which may improve muscle anabolism and prevent hyperhomocysteinemia-induced oxidative stress and endothelial damage, leading to reduced muscle function [107].”
BackgroundSelf-citationGut microbial molecules in behavioural and neurodegenerative conditions
Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379 · see citing works
Ervin, S. M., Li, H., Lim, L., Roberts, L. R., Liang, X., Mani, S., & Redinbo, M. R. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010950 · Cited by 397 · see citing works
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 377 · see citing works
Microplastics and the gut microbiome: How chronically exposed species may suffer from gut dysbiosis
Fackelmann, G., & Sommer, S. (2019) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2019.04.030 · Cited by 385 · see citing works
Fermentation-enabled wellness foods: A fresh perspective
Xiang, H., Sun‐Waterhouse, D., Waterhouse, G. I. N., Cui, C., & Ruan, Z. (2019) · Food Science and Human Wellness · doi:10.1016/j.fshw.2019.08.003 · Cited by 364 · see citing works
Structural variation in the gut microbiome associates with host health
Zeevi, D., Korem, T., Godneva, A., Bar, N., Kurilshikov, A., Lotan-Pompan, M., Weinberger, A., Fu, J., Wijmenga, C., Zhernakova, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1065-y · Cited by 351 · see citing works
Riboflavin and health: A review of recent human research
Thakur, K., Tomar, S. K., Singh, A. K., Mandal, S., & Arora, S. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1145104 · Cited by 349 · see citing works
Bifidobacterium mechanisms of immune modulation and tolerance
Gavzy, S. J., Kensiski, A., Lee, Z. L., Mongodin, E. F., Ma, B., & Bromberg, J. S. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2291164 · Cited by 375 · see citing works
Jing, T., Qi, F., & Wang, Z.-Y. (2020) · Microbiome · doi:10.1186/s40168-020-00823-y · Cited by 343 · see citing works
“For example, no complete pathways for the biosynthesis of biotin, pantothenate, pyridoxine, cobalamin, and menaquinone are present in any of the bifidobacterial genomes sequenced so far [45].”
The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids
Huang, P., Zhang, Y., Xiao, K., Jiang, F., Wang, H., Tang, D., Liu, D., Liu, B., Liu, Y., He, X., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0590-5 · Cited by 339 · see citing works
Turroni, F., Ventura, M., Buttó, L. F., Duranti, S., O’Toole, P. W., Motherway, M. O., & van Sinderen, D. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1318-0 · Cited by 336 · see citing works
“Additional metabolic functions of the gut microbiota include synthesis of vitamins (see review [37]), and bile acid biotransformation [38].”
BackgroundSelf-citationCrosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases
Jiao, Y., Wu, L., Huntington, N. D., & Zhang, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00282 · Cited by 321 · see citing works
Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases
Gerhardt, S., & Mohajeri, M. H. (2018) · Nutrients · doi:10.3390/nu10060708 · Cited by 298 · see citing works
“Also, Lactobacillus reuteri, another species from the Firmicutes phylum, is supposed to be capable of vitamin B12 synthesis [11].”
BackgroundGut microbiota dictates the metabolic response ofDrosophilato diet
Wong, A. C.-N., Dobson, A. J., & Douglas, A. E. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.101725 · Cited by 305 · see citing works
“In broad terms, these findings for Drosophila are congruent with evidence that various animals, including other insects and mammals, bear bacteria that are capable of synthesizing B vitamins and contribute to the vitamin nutrition of their host (Akman et al., 2002; Goodman et al., 2009; Hill, 1997; LeBlanc et al., 201…”
BackgroundA Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota
Jayachandran, M., Xiao, J., & Xu, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091934 · Cited by 299 · see citing works
“Another major metabolic function of the gut microbiota is the synthesis of vitamin K and several components of vitamin B [46].”
BackgroundCervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity
Anahtar, M. N., Gootenberg, D. B., Mitchell, C. M., & Kwon, D. S. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.01.013 · Cited by 296 · see citing works
Abdolmaleky, H. M., & Zhou, J. (2024) · Antioxidants · doi:10.3390/antiox13080985 · Cited by 311 · see citing works
“Furthermore, experimental evidence suggests that the gut microbiota not only contributes to the synthesis and absorption of nutrients and vitamins [45] but also determines the uptake of energy from food.”
BackgroundShandilya, S., Kumar, S., Jha, N. K., Kesari, K. K., & Ruokolainen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.09.005 · Cited by 300 · see citing works
“coli; B9 (folic acid) by Bifidobacterium, Lactococcus lactis and Streptococcus thermophilus; and B12 (cobalamin) is produced by Lactobacillus reuteri and Propionibacterium freudenreichi [260].”
A review of metabolic potential of human gut microbiome in human nutrition
Yadav, M., Verma, M. K., & Chauhan, N. S. (2017) · Archives of Microbiology · doi:10.1007/s00203-017-1459-x · Cited by 288 · see citing works
“Experiments on humans suggested that it is not the lack of vitamin K in the diet that affects prothrombin level, but it is an antibiotic treatment that diminishes the microbiota (LeBlanc et al. 2013).”
BackgroundMicrobiome effects on immunity, health and disease in the lung
Shukla, S. D., Budden, K. F., Neal, R., & Hansbro, P. M. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.6 · Cited by 287 · see citing works
Human gut microbiota: the links with dementia development
Alkasir, R., Li, J., Li, X., Jin, M., & Zhu, B. (2016) · Protein & Cell · doi:10.1007/s13238-016-0338-6 · Cited by 283 · see citing works
“Additionally, fermented milks with high levels of B-group vitamins (such as folate and riboflavin) can be produced by LAB-promoted and possibly Bifidobacteria-promoted biosynthesis (LeBlanc et al., 2013).”
BackgroundPotential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health
Parkar, S. G., Kalsbeek, A., & Cheeseman, J. F. (2019) · Microorganisms · doi:10.3390/microorganisms7020041 · Cited by 285 · see citing works
“B2, riboflavin Affects metabolism by influencingcryptochrome 2 stability [95] Bacillus subtilis, Escherichia coli [94]”
BackgroundBehera, S. S., Sheikha, A. F. E., Hammami, R., & Kumar, A. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103971 · Cited by 281 · see citing works
Vitamins, the gut microbiome and gastrointestinal health in humans
Pham, V. T., Dold, S., Rehman, A., Bird, J. K., & Steinert, R. E. (2021) · Nutrition Research · doi:10.1016/j.nutres.2021.09.001 · Cited by 286 · see citing works
Microbial modulation of insulin sensitivity
Khan, M. T., Nieuwdorp, M., & Bäckhed, F. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.006 · Cited by 260 · see citing works
Moon, C., Young, W., Maclean, P., Cookson, A., & Bermingham, E. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.677 · Cited by 223 · see citing works
The nutrition‐gut microbiome‐physiology axis and allergic diseases
McKenzie, C. I., Tan, J., Macia, L., & Mackay, C. R. (2017) · Immunological Reviews · doi:10.1111/imr.12556 · Cited by 271 · see citing works
Watson, E. V., MacNeil, L. T., Ritter, A. D., Yilmaz, L. S., Rosebrock, A. P., Caudy, A. A., & Walhout, A. J. M. (2014) · Cell · doi:10.1016/j.cell.2014.01.047 · Cited by 269 · see citing works
“Considering thatmany species of enteric bacteria can synthesize this essential vitamin suggests that the chemical outsourcing of vitamin B12 productionmay be an important keystone of amutually beneficial relationship between gut microbiota and host cells (Albert et al., 1980; Goodman et al., 2009; LeBlanc et al., 2013…”
BackgroundThe Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism
Weger, B. D., Gobet, C., Yeung, J., Martin, E., Jimenez, S., Betrisey, B., Foata, F., Berger, B., Balvay, A., Foussier, A., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.023 · Cited by 269 · see citing works
“Microbiota is an important supplier of de novo synthesized folate to the host (LeBlanc et al., 2013), which likely led to the lower levels of folate and DHF in GF male mice.”
BackgroundMicrobial translocation and microbiome dysbiosis in HIV-associated immune activation
Zevin, A. S., McKinnon, L. R., Burgener, A., & Klatt, N. R. (2015) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000234 · Cited by 268 · see citing works
Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5
Hrubša, M., Siatka, T., Najmanová, I., Vopršalová, M., Krčmová, L. K., Matoušová, K., Javorská, L., Macáková, K., Mercolini, L., Remião, F., et al. (2022) · Nutrients · doi:10.3390/nu14030484 · Cited by 277 · see citing works
Ketogenic Diet and Microbiota: Friends or Enemies?
Paoli, A., Mancin, L., Bianco, A., Thomas, E., Mota, J. F., & Piccini, F. (2019) · Genes · doi:10.3390/genes10070534 · Cited by 265 · see citing works
“More important, microorganisms have the ability to produce a great amount of B12 and K vitamins, essential for human health, especially for the daily vitamin K intake that is most frequently insufficient [18,19].”
BackgroundAbraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2018.12.005 · Cited by 260 · see citing works
“reuteri is a known vitamin B12 producer (Leblanc et al., 2013) and in this study elevated levels of L.”
Everard, A., & Cani, P. D. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9288-6 · Cited by 266 · see citing works
“Importantly, functions encoded by these microbial genes are relevant to their survival, but our gut microbial gene set also assumes metabolic and biological host functions including the control of energy homeostasis, immune system regulation, vitamin synthesis and digestion [12–18].”
BackgroundThe Role of Microbiota in Infant Health: From Early Life to Adulthood
Yao, Y., Cai, X. T., Ye, Y., Wang, F., Chen, F., & Zheng, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708472 · Cited by 264 · see citing works
Effectiveness of probiotics, prebiotics, and prebiotic‐like components in common functional foods
Peng, M., Tabashsum, Z., Anderson, M., Truong, A., Houser, A., Padilla, J., Akmel, A., Bhatti, J., Rahaman, S. O., & Biswas, D. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12565 · Cited by 258 · see citing works
Nutrition meets the microbiome: micronutrients and the microbiota
Biesalski, H. K. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13145 · Cited by 255 · see citing works
Bae, S., Ulrich, C. M., Neuhouser, M. L., Malysheva, O., Bailey, L. B., Xiao, L., Brown, E. C., Cushing-Haugen, K. L., Zheng, Y., Cheng, T.-Y. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1835 · Cited by 253 · see citing works
“Certain groups of intestinal bacteria can synthesize (45, 46) and consume (47, 48) vitamin B12, 291 which may impact the vitamin B12 requirement/status of the host.”
Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy
Duan, H., Yu, L., Tian, F., Zhai, Q., Fan, L., & Chen, W. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.140429 · Cited by 247 · see citing works
Metabolism of anthocyanins and consequent effects on the gut microbiota
Tian, L., Tan, Y., Chen, G., Wang, G., Sun, J., Ou, S., Chen, W., & Bai, W. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1533517 · Cited by 234 · see citing works
“Gut microbiota can play a key role in vitamin synthesis (mainly thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, biotin and vitamin B12) (LeBlanc et al. 2013).”
BackgroundHealthy Human Gastrointestinal Microbiome: Composition and Function After a Decade of Exploration
Ruan, W. H., Engevik, M. A., Spinler, J. K., & Versalovic, J. A. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06118-4 · Cited by 240 · see citing works
“Interestingly, recent studies have linked vitamin deficiencies with antibiotic-diminished gut microbiota, solidifying a distinct contribution of microbial vitamins to host health that differs from vitamin supplementation in the diet [154].”
BackgroundGut microbiota: Implications in Parkinson's disease
Parashar, A., & Malairaman, U. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.02.002 · Cited by 231 · see citing works
“[ production of antioxidant vitamins, preventing oxidative damage in PD [54, 55, 67] .”
Nutritional Keys for Intestinal Barrier Modulation
De Santis, S., Cavalcanti, E., Mastronardi, M., Jirillo, E., & Chieppa, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00612 · Cited by 232 · see citing works
Microbiome disturbances and autism spectrum disorders
Rosenfeld, C. S. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063826 · Cited by 229 · see citing works
“Gut microbiota synthesize various essential vitamins and cofactors, such as folate and vitamin B12, which may affect DNA and histone protein methylation (Le Galliard et al., 2008; LeBlanc et al., 2013).”
BackgroundGut Microbiota Metabolism and Interaction with Food Components
Vernocchi, P., CHIERICO, F. D., & Putignani, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103688 · Cited by 236 · see citing works
The role of the gut microbiota in dietary interventions for depression and anxiety
Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229 · see citing works
Bhat, M. I., & Kapila, R. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux001 · Cited by 227 · see citing works
Nagy‐Szakal, D., Williams, B. L., Mishra, N., Che, X., Lee, B., Bateman, L., Klimas, N. G., Komaroff, A. L., Levine, S. M., Montoya, J. G., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0261-y · Cited by 221 · see citing works
Stegelmeier, A. A., Müller, K. M., Weese, J. S., & Neufeld, J. D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801302115 · Cited by 221 · see citing works
“Many advances have been made in gut microbiome research that have demonstrated microorganisms within the gastrointestinal tract can influence digestion (44), provide vitamins and amino acids that the host is unable to synthesize alone (45), and impact neurological function through the gut–brain axis (46).”
BackgroundLactic acid bacteria as a cell factory for riboflavin production
Thakur, K., Tomar, S. K., & De, S. (2015) · Microbial Biotechnology · doi:10.1111/1751-7915.12335 · Cited by 222 · see citing works
“The possibility of co-evolution of gut microbes in the human gut makes them suitable for de novo synthesis (LeBlanc et al., 2012; Magnusdottir et al., 2015).”
BackgroundInfluentialFunctional Roles of B‐Vitamins in the Gut and Gut Microbiome
Uebanso, T., Shimohata, T., Mawatari, K., & Takahashi, A. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000426 · Cited by 218 · see citing works
Milani, C., Ticinesi, A., Gerritsen, J., Nouvenne, A., Lugli, G. A., Mancabelli, L., Turroni, F., Duranti, S., Mangifesta, M., Viappiani, A., et al. (2016) · Scientific Reports · doi:10.1038/srep25945 · Cited by 216 · see citing works
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Gut Dysbiosis in Animals Due to Environmental Chemical Exposures
Rosenfeld, C. S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00396 · Cited by 207 · see citing works
Sustainable farming of the mealworm Tenebrio molitor for the production of food and feed
Grau, T., Vilcinskas, A., & Joop, G. (2017) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2017-0033 · Cited by 208 · see citing works
“Probiotic bacteria increase the nutritional value of mealworms because they are known to produce health-promoting metabolites such as B vitamins [122, 123].”
BackgroundEngevik, M. A., Morra, C. N., Röth, D., Engevik, K. A., Spinler, J. K., Devaraj, S., Crawford, S. E., Estes, M. K., Kalkum, M., & Versalovic, J. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02305 · Cited by 206 · see citing works
Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism
Wang, Y., Shou, J., Li, X., Zhao, Z., Fu, J., He, C., Feng, R., Ma, C., Wen, B., Guo, F., et al. (2017) · Metabolism · doi:10.1016/j.metabol.2017.02.003 · Cited by 206 · see citing works
Whole cereal grains and potential health effects: Involvement of the gut microbiota
Gong, L., Cao, W., Chi, H., Wang, J., Zhang, H., Liu, J., & Sun, B. (2017) · Food Research International · doi:10.1016/j.foodres.2017.10.025 · Cited by 204 · see citing works
Biopolymers from Lactic Acid Bacteria. Novel Applications in Foods and Beverages
Torino, M. I., Font de Valdez, G., & Mozzi, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00834 · Cited by 201 · see citing works
Lamichhane, S., Sen, P., Dickens, A. M., Orešič, M., & Bertram, H. C. (2018) · Methods · doi:10.1016/j.ymeth.2018.04.029 · Cited by 200 · see citing works
Links between the microbiome and bone
Hernandez, C. J., Guss, J. D., Luna, M., & Goldring, S. R. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2887 · Cited by 200 · see citing works
“Microbiota confer benefits to the host that include vitamin production,((3)) nutrient and energy extraction from diet,((4)) metabolic function,((5)) regulation of innate and adaptive immunity,((6,7)) and protection from pathogenic organisms.”
BackgroundDevelopment of the Pediatric Gut Microbiome: Impact on Health and Disease
Ihekweazu, F. D., & Versalovic, J. A. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.08.005 · Cited by 201 · see citing works
Diet-microbiota interactions and their implications for healthy living
Jeffery, I., & O'Toole, P. (2013) · Nutrients · doi:10.3390/nu5010234 · Cited by 199 · see citing works
“A number of other B-group vitamins that are synthesised by members of the microbiota and that may be produced in the gut include riboflavin, vitamin B12, niacin and pyridoxine [58].”
BackgroundMechanisms and implications of the gut microbial modulation of intestinal metabolic processes
Jyoti, & Dey, P. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00066-1 · Cited by 217 · see citing works
- Authors
- LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- University of Parma (IT)
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 24
- Issue
- 2
- Pages
- 160-168
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2057179832
- Cited by
- 1,613
- References
- 74
- Citations by year
- 2026: 127 · 2025: 158 · 2024: 181 · 2023: 154 · 2022: 159 · 2021: 149 · 2020: 150 · 2019: 126 · 2018: 120 · 2017: 112 · 2016: 68 · 2015: 48 · 2014: 33 · 2013: 25 · 2012: 2
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Science Foundation Ireland (08/SRC/B1393, 07/CE/B1368)
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Alimentary Glycoscience Research Cluster (08/SRC/B1393)
- Agencia Nacional de Promoción Científica y Tecnológica (CONICET)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- vitamin biosynthesis, lactic acid bacteria, Bifidobacterium, gut microbiota, B vitamins, folic acid, riboflavin, vitamin B12, fermented milk, starter cultures, vitamin deficiency
- MeSH terms
- Bacteria, Folic Acid, Humans, Intestines, Riboflavin, Vitamin B 12, Vitamin K, Vitamins, Lactic Acid, Metagenome
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