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Characteristic features and biotechnological applications of cross-linked enzyme aggregates (CLEAs)
Open accessAbstract
Cross-linked enzyme aggregates (CLEAs) have many economic and environmental benefits in the context of industrial biocatalysis. They are easily prepared from crude enzyme extracts, and the costs of (often expensive) carriers are circumvented. They generally exhibit improved storage and operational stability towards denaturation by heat, organic solvents, and autoproteolysis and are stable towards leaching in aqueous media. Furthermore, they have high catalyst productivities (kilograms product per kilogram biocatalyst) and are easy to recover and recycle. Yet another advantage derives from the possibility to co-immobilize two or more enzymes to provide CLEAs that are capable of catalyzing multiple biotransformations, independently or in sequence as catalytic cascade processes.
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Cites
Directed evolution drives the next generation of biocatalysts
Turner, N. J. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.203 · Cited by 785
Cited by
Enzyme immobilisation in biocatalysis: why, what and how
Sheldon, R. A., & van Pelt, S. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60075k · Cited by 2,675
Self-citationCofactor NAD(P)H Regeneration Inspired by Heterogeneous Pathways
Wang, X., Saba, T., Yiu, H. H. P., Howe, R. F., Anderson, J. A., & Shi, J. (2017) · Chem · doi:10.1016/j.chempr.2017.04.009 · Cited by 478
Cantone, S., Ferrario, V., Corici, L., Ebert, C., Fattor, D., Spizzo, P., & Gardossi, L. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35464d · Cited by 447
Bilal, M., Asgher, M., Parra-Saldivar, R., Hu, H., Wang, W., Zhang, X., & Iqbal, H. M. N. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2016.10.137 · Cited by 382
Strategies of enzyme immobilization on nanomatrix supports and their intracellular delivery
Sharifi, M., Karim, A. Y., Mustafa Qadir Nanakali, N., Salihi, A., Aziz, F. M., Hong, J., Khan, R. H., Saboury, A. A., Hasan, A., Abou-Zied, O. K., et al. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2019.1643787 · Cited by 29
Metadata
- Authors
- Sheldon, R. A.
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2011-09-02
- Volume
- 92
- Issue
- 3
- Pages
- 467-477
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W2154602192
- Cited by
- 493
- References
- 1
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sheldon, R. A. (2011). Characteristic features and biotechnological applications of cross-linked enzyme aggregates (CLEAs). Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-011-3554-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
