The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Sialic acid metabolism and sialyltransferases: natural functions and applications
Open accessAbstract
Sialic acids are a family of negatively charged monosaccharides which are commonly presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell surface or as components of capsular polysaccharides or lipooligosaccharides of some pathogenic bacteria. Due to their important biological and pathological functions, the biosynthesis, activation, transfer, breaking down, and recycle of sialic acids are attracting increasing attention. The understanding of the sialic acid metabolism in eukaryotes and bacteria leads to the development of metabolic engineering approaches for elucidating the important functions of sialic acid in mammalian systems and for large-scale production of sialosides using engineered bacterial cells. As the key enzymes in biosynthesis of sialylated structures, sialyltransferases have been continuously identified from various sources and characterized. Protein crystal structures of seven sialyltransferases have been reported. Wild-type sialyltransferases and their mutants have been applied with or without other sialoside biosynthetic enzymes for producing complex sialic acid-containing oligosaccharides and glycoconjugates. This mini-review focuses on current understanding and applications of sialic acid metabolism and sialyltransferases.
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Dobie, C., & Skropeta, D. (2021) · British Journal of Cancer · doi:10.1038/s41416-020-01126-7 · Cited by 348
Exploration of the Sialic Acid World
(2018) · Advances in Carbohydrate Chemistry and Biochemistry · doi:10.1016/bs.accb.2018.09.001 · Cited by 320
Lin, N., Mascarenhas, J., Sealover, N. R., George, H. J., Brooks, J., Kayser, K. J., Gau, B., Yasa, I., Azadi, P., & Archer‐Hartmann, S. (2015) · Biotechnology Progress · doi:10.1002/btpr.2038 · Cited by 73
Glycoengineering in CHO cells: advances in systems biology
Tejwani, V., Andersen, M. R., Nam, J. H., & Sharfstein, S. T. (2018) · Biotechnology Journal · doi:10.1002/biot.201700234 · Cited by 70
Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions
Cerullo, A. R., McDermott, M. B., Pepi, L. E., Liu, Z.-L., Barry, D., Zhang, S., Yang, X., Chen, X., Azadi, P., Holford, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41094-z · Cited by 35
Self-citation
Metadata
- Authors
- Li, Y., & Chen, X.
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2012-04-13
- Volume
- 94
- Issue
- 4
- Pages
- 887-905
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W1991930901
- Cited by
- 281
- References
- 148
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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