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Cited by 35Polymer Surface Interaction StudiesPolysaccharides Composition and ApplicationsHydrogels: synthesis, properties, applications

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Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions

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Cerullo, Antonio R., McDermott, Maxwell B., Pepi, Lauren E., Liu, Zhi-Lun, Barry, Diariou, Zhang, Sheng, Yang, Xu, Chen, Xi, Azadi, Parastoo, Holford, Mande, Braunschweig, Adam B.·2023·Nature Communications
DOI 10.1038/s41467-023-41094-zPMC PMC10475054
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Abstract

Every animal secretes mucus, placing them among the most diverse biological materials. Mucus hydrogels are complex mixtures of water, ions, carbohydrates, and proteins. Uncertainty surrounding their composition and how interactions between components contribute to mucus function complicates efforts to exploit their properties. There is substantial interest in commercializing mucus from the garden snail, Cornu aspersum , for skincare, drug delivery, tissue engineering, and composite materials. C. aspersum secretes three mucus—one shielding the animal from environmental threats, one adhesive mucus from the pedal surface of the foot, and another pedal mucus that is lubricating. It remains a mystery how compositional differences account for their substantially different properties. Here, we characterize mucus proteins, glycosylation, ion content, and mechanical properties that could be used to provide insight into structure-function relationships through an integrative “mucomics” approach. We identify macromolecular components of these hydrogels, including a previously unreported protein class termed Conserved Anterior Mollusk Proteins (CAMPs). Revealing differences between C. aspersum mucus shows how considering structure at all levels can inform the design of mucus-inspired materials.

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Metadata

Authors
Cerullo, A. R., McDermott, M. B., Pepi, L. E., Liu, Z.-L., Barry, D., Zhang, S., Yang, X., Chen, X., Azadi, P., Holford, M., & Braunschweig, A. B.
Affiliations
  • The Graduate Center, CUNY (US)
  • Hunter College (US)
  • University of Georgia (US)
Corresponding author
Braunschweig, Adam B.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2023-09-02
Volume
14
Issue
1
Pages
5361-5361
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-023-41094-z
PMC
PMC10475054
OpenAlex
W4386390645
Cited by
35
References
4
Citations by year
2026: 7 · 2025: 16 · 2024: 6 · 2023: 6
FWCI
2.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • United States Department of Defense | United States Air Force | AFMC | Air Force Office of Scientific Research (FA-9550-19-1-022-, FA9550-18-1-0142, FA9550-23-1-023)
  • National Science Foundation (DMR-2212139, DMR-1933525)
  • United States Department of Defense | United States Navy | Office of Naval Research (N00014-18-1-2492)
  • U.S. Department of Health & Human Services | National Institutes of Health (R24GM137782)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords
Helix aspersa, mucus proteins, glycosylation, ion content, structure-function relationship
MeSH terms
Animals, Meat, Mucus, Hydrogels, Cornus, Gastropoda

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