The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
Open accessAbstract
Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each strain contains genes that encode the enzymes to synthesize a plethora of potential secondary metabolites, only a fraction are expressed during fermentation. Interest has therefore grown in the activation of these cryptic pathways. We review current progress on this topic, describing concepts for activating silent genes, utilization of "natural" mutant-type RNA polymerases and rare earth elements, and the applicability of ribosome engineering to myxobacteria and fungi, the microbial groups known as excellent searching sources, as well as actinomycetes, for secondary metabolites.
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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
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Big Effects from Small Changes: Possible Ways to Explore Nature's Chemical Diversity
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Regulation of secondary metabolism in streptomycetes
Bibb, M. J. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2005.02.016 · Cited by 821
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Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350
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Evolution of sensory complexity recorded in a myxobacterial genome
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Cited by
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
Rutledge, P. J., & Challis, G. L. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3496 · Cited by 986
Actinomycetes: Still a source of novel antibiotics
Genilloud, O. (2017) · Natural Product Reports · doi:10.1039/c7np00026j · Cited by 465
Valliappan, K., Sun, W., & Li, Z. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-5954-6 · Cited by 111
Metadata
- Authors
- Ochi, K., & Hosaka, T.
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2012-11-11
- Volume
- 97
- Issue
- 1
- Pages
- 87-98
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W1969089572
- Cited by
- 302
- References
- 65
- FWCI
- 15.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
