Actinomycetes: Still a source of novel antibiotics
Abstract
An update on last ten years of actinomycetes antibiotic discovery, including recent key molecules in clinical development and overlooked compounds discovered using novel strategies.
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Actinomycetes are undoubtedly the largest producers of secondary metabolites among marine microorganisms.
“Actinomycetes are undoubtedly the largest producers of secondary metabolites among marine microorganisms [124].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [124]
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
“Actinomycetes are undoubtedly the largest producers of secondary metabolites among marine microorganisms [124].”
Background
- Authors
- Genilloud, O.
- Affiliations
- Fundación Medina (ES)
- Corresponding author
- Genilloud, Olga
- ORCID
- Genilloud, Olga
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 34
- Issue
- 10
- Pages
- 1203-1232
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2745396386
- Cited by
- 465
- References
- 170
- Citations by year
- 2026: 49 · 2025: 51 · 2024: 44 · 2023: 38 · 2022: 60 · 2021: 75 · 2020: 48 · 2019: 58 · 2018: 40 · 2017: 1
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Reports (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- Funders
- Novo Nordisk Fonden (NNF16OC0021746)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- actinomycetes, antibiotic discovery, novel antibiotics, natural products, whole-cell screening, dereplication, heterologous expression, chemical diversity
- MeSH terms
- Anti-Bacterial Agents, Biological Products, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Actinobacteria, Drug Discovery
About these checks
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