PET/CT-guided biopsies of metabolically active bone lesions: applications and clinical impact
Open accessAbstract
Purpose In a minority of cases a definite diagnosis and stage grouping in cancer patients is not possible based on the imaging information of PET/CT. We report our experience with percutaneous PET/CT-guided bone biopsies to histologically verify the aetiology of hypermetabolic bone lesions.Methods We retrospectively reviewed the data of 20 consecutive patients who underwent multimodal image-guided bone biopsies using a dedicated PET/CT system in a step-by-step technique. Technical and clinical success rates of PET/CT-guided biopsies were evaluated. Questionnaires were sent to the referring physicians to assess the impact of biopsies on patient management and to check the clinical need for PET/CT-guided biopsies.Results Clinical indications for biopsy were to histologically verify the aetiology of metabolically active bone lesions without a morphological correlate confirming the suspicion of metastases in 15 patients, to determine the origin of suspected metastases in 3 patients and to evaluate the appropriateness of targeted therapy options in 2 patients. Biopsies were technically successful in all patients. In 19 of 20 patients a definite histological diagnosis was possible. No complications or adverse effects occurred. The result of PET/CT-guided bone biopsies determined a change of the planned treatment in overall 56% of patients, with intramodality changes, e.g. chemotherapy with palliative instead of curative intent, and intermodality changes, e.g. systemic therapy instead of surgery, in 22 and 50%, respectively.Conclusion PET/CT-guided bone biopsies are a promising alternative to conventional techniques to make metabolically active bone lesions-especially without a distinctive morphological correlate-accessible for histological verification. PET/CT-guided biopsies had a major clinical impact in patients who otherwise cannot be reliably stage grouped at the time of treatment decisions.
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PET overlay of functional information on CT or MR images has been shown to better guide biopsies in the abdomen and in patients with bone disease.
“This has already been shown with the use of PET to overlay functional information on CT or MR images to better guide biopsies in the abdomen and in patients with bone disease (60,61).”
From Radiomics: Images Are More than Pictures, They Are Data (2016) · cites this paper as [60]
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Lardinois, D., Weder, W., Hany, T. F., Kamel, E. M., Korom, S., Seifert, B., von Schulthess, G. K., & Steinert, H. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022136 · Cited by 1,416 · see citing works
Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006.
Czernin, J. G., Allen-Auerbach, M., & Schelbert, H. R. (2007) · PubMed · Cited by 361 · see citing works
FDG PET of Primary Benign and Malignant Bone Tumors: Standardized Uptake Value in 52 Lesions
Aoki, J., Watanabe, H., Shinozaki, T., et al. (2001) · Radiology · doi:10.1148/radiology.219.3.r01ma08774 · Cited by 318 · see citing works
Detection of unexpected additional primary malignancies with PET/CT.
Ishimori, T., Patel, P. V., & Wahl, R. L. (2005) · PubMed · Cited by 280 · see citing works
PET/CT for the staging and follow-up of patients with malignancies
Poeppel, T. D., Krause, B. J., Heusner, T. A., Boy, C., Bockisch, A., & Antoch, G. (2009) · European Journal of Radiology · doi:10.1016/j.ejrad.2009.03.051 · Cited by 197 · see citing works
Naumann, R., Beuthien‐Baumann, B., Reiss, A. L., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601561 · Cited by 172 · see citing works
Kitajima, K., Murakami, K., Yamasaki, E., et al. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0890-2 · Cited by 172 · see citing works
Lis, E., Bilsky, M. H., Pisinski, L., et al. (2004) · PubMed · Cited by 150 · see citing works
Metser, U., Miller, E., Lerman, H., & Even‐Sapir, E. (2007) · American Journal of Roentgenology · doi:10.2214/ajr.07.2083 · Cited by 141 · see citing works
Buhmann, S., Becker, C. R., Duerr, H. R., et al. (2008) · European Journal of Radiology · doi:10.1016/j.ejrad.2007.11.039 · Cited by 125 · see citing works
Effect of 18F-FDG PET/CT Imaging in Patients With Clinical Stage II and III Breast Cancer
Groheux, D., Moretti, J., Baillet, G. Y., et al. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.02.056 · Cited by 122 · see citing works
Synchronous primary neoplasms detected on 18F-FDG PET in staging of patients with esophageal cancer.
van Westreenen, H. L., Westerterp, M., Jager, P. L., et al. (2005) · PubMed · Cited by 98 · see citing works
Bastiaannet, E., Wobbes, T., Hoekstra, O. S., van der Jagt, E. J., Brouwers, A. H., Koelemij, R., de Klerk, J. M. H., Oyen, W. J. G., Meijer, S., & Hoekstra, H. J. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.1822 · Cited by 94 · see citing works
Klaeser, B., Mueller, M. D., Schmid, R. A., et al. (2009) · European Radiology · doi:10.1007/s00330-009-1338-1 · Cited by 85 · see citing works
Self-citationWang, G., Lau, E. W. F., Ramdave, S., Rischin, D., Ware, R. E., Hong, E., Binns, D., Hogg, A., Drummond, E. G. P., & Hicks, R. J. (2006) · Cancer · doi:10.1002/cncr.22370 · Cited by 73 · see citing works
The clinical impact of integrated FDG PET–CT on management decisions in patients with lung cancer
Subedi, N., Scarsbrook, A. F., Darby, M., et al. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.09.006 · Cited by 67 · see citing works
Strobel, K., Exner, U. E., Stumpe, K. D. M., et al. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0876-0 · Cited by 64 · see citing works
Ludwig, V. B., FORDICE, S., Lamar, R. E., Martin, W. H., & Delbeke, D. (2003) · Clinical Nuclear Medicine · doi:10.1097/01.rlu.0000053528.35645.70 · Cited by 52 · see citing works
Role of PET or PET/CT in the post-therapy surveillance of uterine sarcoma
Park, J., Kim, E. N., Kim, D., et al. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.01.030 · Cited by 50 · see citing works
Allen-Auerbach, M., de Vos, S., & Czernin, J. G. (2008) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2008.03.004 · Cited by 48 · see citing works
“One-stop-shop” staging: Should we prefer FDG-PET/CT or MRI for the detection of bone metastases?
Heusner, T. A., Gölitz, P., Hamami, M., Eberhardt, W., Eßer, S., Forsting, M., Bockisch, A., & Antoch, G. (2009) · European Journal of Radiology · doi:10.1016/j.ejrad.2009.10.031 · Cited by 48 · see citing works
Strobel, K., Bode, B., Lardinois, D., et al. (2006) · Skeletal Radiology · doi:10.1007/s00256-006-0152-y · Cited by 36 · see citing works
Stegger, L., Juergens, K. U., Kliesch, S., et al. (2006) · European Radiology · doi:10.1007/s00330-006-0466-0 · Cited by 35 · see citing works
Mahmood, S., & de Llano, S. R. M. (2008) · Clinical Nuclear Medicine · doi:10.1097/rlu.0b013e318177928a · Cited by 32 · see citing works
Klaeser, B., Wiederkehr, O., Koeberle, D., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm139 · Cited by 26 · see citing works
Self-citationIntensity of FDG Uptake Is Not Everything
Charest, M., Singnurkar, A., Hickeson, M. P., et al. (2008) · Clinical Nuclear Medicine · doi:10.1097/rlu.0b013e31817793bb · Cited by 16 · see citing works
CT-guided interventions in orthopedics
Huch, K., Röderer, G., Ulmar, B., et al. (2007) · Archives of Orthopaedic and Trauma Surgery · doi:10.1007/s00402-007-0410-z · Cited by 14 · see citing works
Dorado, I. B., Albertino, R. V., Martin, J., et al. (2006) · Revista Española de Medicina Nuclear · doi:10.1157/13092697 · Cited by 3 · see citing works
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Research works printed but not linked: 1
- Borrego Dorado I, Vázquez Albertino R, López Martín J, Alvarez Pérez RM. Evaluation of efficacy and clinical impact of FDG-PET on patients with suspicion of recurrent cutaneous melanoma. Rev Esp Med Nucl 2006;25:301-11. 13092697.
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Radiomics: Images Are More than Pictures, They Are Data
Gillies, R. J., Kinahan, P. E., & Hricak, H. (2016) · Radiology · doi:10.1148/radiol.2015151169 · Cited by 8,421 · see citing works
- Authors
- Klaeser, B., Wiskirchen, J., Wartenberg, J., Weitzel, T., Schmid, R. A., Mueller, M. D., & Krause, T.
- Affiliations
- University of Bern (CH)
- Corresponding author
- Wiskirchen, Jakub
- Venue
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2010-08-03
- Volume
- 37
- Issue
- 11
- Pages
- 2027-2036
- ISSN
- 1619-7070 (ISSN-L)
- 1619-7089
- OpenAlex
- W2111013601
- Cited by
- 68
- References
- 28
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 12 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- BORIS (University Library Bern) (submittedVersion, other-oa)
- Open Access CRIS of the University of Bern
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Oncology › Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Keywords
- bone metastasis, percutaneous biopsy, histopathological diagnosis, tumor staging, treatment decision change, image-guided biopsy
- MeSH terms
- Aged, Biopsy, Bone Neoplasms, Humans, Male, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Surgery, Computer-Assisted, Positron-Emission Tomography
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