Cited by 160Radiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and ApplicationsProstate Cancer Diagnosis and Treatment

PSMA PET total tumor volume predicts outcome of patients with advanced prostate cancer receiving [177Lu]Lu-PSMA-617 radioligand therapy in a bicentric analysis

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Seifert, Robert, Kessel, Katharina, Schlack, Katrin, Weber, Manuel, Herrmann, Ken, Spanke, Maximilian, Fendler, Wolfgang P., Hadaschik, Boris +5 more·2021·European Journal of Nuclear Medicine and Molecular Imaging

Abstract

Abstract Introduction [ 177 Lu]Lu-PSMA-617 (Lu-PSMA) radioligand therapy is an emerging treatment option for patients with end-stage prostate cancer. However, response to Lu-PSMA therapy is only achieved in approximately half of patients. It is clinically important to identify patients at risk of poor outcome. Therefore, the aim of this study was to evaluate pretherapeutic PSMA PET derived total tumor volume and related metrics as prognosticators of overall survival in patients receiving Lu-PSMA therapy. Methods A total number of 110 patients form the Departments of Nuclear Medicine Münster and Essen were included in this retrospective analysis. Baseline PSMA PET-CT was available for all patients. Employing a previously published approach, all tumor lesions were semi-automatically delineated in PSMA PET-CT acquisitions. Total lesion number, total tumor volume (PSMA-TV), total lesion uptake (PSMA-TLU = PSMA-TV * SUV mean ), and total lesion quotient (PSMA-TLQ = PSMA-TV / SUV mean) were quantified for each patient. Log2 transformation was used for regressions. Results Lesion number, PSMA-TV, and PSMA-TLQ were prognosticators of overall survival (HR = 1.255, p = 0.009; HR = 1.299, p = 0.005; HR = 1.326, p = 0.002). In a stepwise backward Cox regression including lesion number, PSMA-TV, PSA, LDH, and PSMA-TLQ, only the latter two remained independent and statistically significant negative prognosticators of overall survival (HR = 1.632, p = 0.011; HR = 1.239, p = 0.024). PSMA-TLQ and LDH were significant negative prognosticators in multivariate Cox regression in contrast to PSA value. Conclusion PSMA-TV was a statistically significant negative prognosticator of overall survival in patients receiving Lu-PSMA therapy. PSMA-TLQ was an independent and superior prognosticator of overall survival compared with PSMA-TV.

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  • Initial results show a prognostic value of PSMA-PET tumor volume in prostate cancer prior to radioligand therapy with [177Lu]Lu-PSMA-617.

    “Initial results also show a prognostic value of PSMA-PET tumor volume in prostate cancer prior to radioligand therapy with [177Lu]Lu-PSMA-617 [204].”

    From Influences on PET Quantification and Interpretation (2022) · cites this paper as [204]

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Authors
Seifert, R., Kessel, K., Schlack, K., Weber, M., Herrmann, K., Spanke, M., Fendler, W. P., Hadaschik, B., Kleesiek, J., Schäfers, M., Weckesser, M., Boegemann, M., & Rahbar, K.
Affiliations
  • University Hospital Münster (DE)
  • Essen University Hospital (DE)
  • German Cancer Research Center (DE)
Corresponding author
Rahbar, Kambiz
Venue
European Journal of Nuclear Medicine and Molecular Imaging
Published
2020-09-24
Volume
48
Issue
4
Pages
1200-1210
ISSN
  • 1619-7070 (ISSN-L)
  • 1619-7089
OpenAlex
W3088497176
Cited by
160
References
26
Citations by year
2026: 31 · 2025: 31 · 2024: 25 · 2023: 26 · 2022: 20 · 2021: 24 · 2020: 2
FWCI
8.77
Type
journal article
Language
en
Open access
Locations
  • European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
  • Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Funders
Westfälische Wilhelms-Universität Münster
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
Keywords
177Lu-PSMA-617, radioligand therapy, advanced prostate cancer, PSMA PET/CT, total tumor volume, prognostic factors, overall survival, PSMA-617, PSMA-11, tumor volume measurement
MeSH terms
Positron Emission Tomography Computed Tomography, Dipeptides, Heterocyclic Compounds, 1-Ring, Humans, Male, Retrospective Studies, Treatment Outcome, Prostate-Specific Antigen, Tumor Burden, Prostatic Neoplasms, Castration-Resistant

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