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Cited by 30Colorectal Cancer Screening and DetectionColorectal Cancer Surgical TreatmentsGenetic factors in colorectal cancer

Diagnostic accuracy of MR colonography with fecal tagging

Achiam, Michael Patrick, Løgager, Vibeke Berg, Chabanova, Elizaveta, Eegholm, Bodil, Thomsen, Henrik Segelcke, Rosenberg, Jacob·2009·Abdominal Imaging
DOI 10.1007/s00261-008-9402-x
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Abstract

Background MR colonography (MRC) is a non-invasive method of examining the colon, but it is still only used in a few specialized centers on a daily basis. The purpose of this study was to evaluate the performance of MRC with improved fecal tagging vs. conventional colonoscopy (CC).Methods Between March 2006 and February 2007, consecutive patients who received first-time referrals to CC were asked to participate in the study. Two days prior to MRC, a new contrast mixture (barium/ferumoxsil) was ingested together with four meals each day. Standard bowel cleansing was performed before CC. MRC was evaluated by two blinded observers. MRC results were compared with CC.Results A total of 56 patients were included. The per-polyp sensitivity was 85.7% for polyps 6-10 mm and 81.3% for polyps >10 mm. The per-patient sensitivity/specificity was 100%/80% for polyps >6 mm and 100%/91.4% for polyps >10 mm.Conclusion MRC showed acceptable per-patient sensitivities, but the per-polyp sensitivities are still compromised by the fecal tagging. MRC may be implemented, but at the present time MRC with fecal tagging is not ready for widespread use, although it remains a very promising diagnostic tool.

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  • Ferumoxsil, with a hydrodynamic diameter around 300 nm, is given as an oral contrast enhancement agent for gastrointestinal imaging and examination of the bowel.

    “Ferumoxsil, with a hydrodynamic diameter around 300 nm, is given as an oral contrast enhancement agent for gastrointestinal imaging and examination of the bowel [153].”

    From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [153]

  • At present, ferumoxsil is the only iron oxide nanoparticle approved by the FDA for imaging purposes.

    “At present, ferumoxsil (Lumirem (USA), GastroMARK (EU)) is the only iron oxide nanoparticle approved by the FDA for imaging purposes.”

    From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [153]

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Authors
Achiam, M. P., Løgager, V. B., Chabanova, E., Eegholm, B., Thomsen, H. S., & Rosenberg, J.
Affiliations
Herlev Hospital (DK)
Corresponding author
Achiam, Michael Patrick
ORCID
Venue
Abdominal Imaging
Publisher
Springer Science and Business Media LLC
Published
2008-05-02
Volume
34
Issue
4
Pages
483-490
ISSN
  • 0942-8925 (ISSN-L)
  • 1432-0509
DOI
10.1007/s00261-008-9402-x
OpenAlex
W1998986140
Cited by
30
References
29
Citations by year
2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
2.81
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Abdominal Imaging (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
MR colonography, fecal tagging, colonoscopy, colorectal polyps, diagnostic accuracy, sensitivity and specificity
MeSH terms
Adult, Barium Sulfate, Colonic Diseases, Colonoscopy, Contrast Media, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Meglumine, Organometallic Compounds, Sensitivity and Specificity, Siloxanes, Ferrosoferric Oxide, Magnetite Nanoparticles

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