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Cited by 280

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

A systematic review of humoral immune responses against tumor antigens

Open access
Reuschenbach, Miriam, von Knebel Doeberitz, Magnus, Wentzensen, Nicolas·2009·Cancer Immunology, Immunotherapy
DOI 10.1007/s00262-009-0733-4
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Abstract

This review summarizes studies on humoral immune responses against tumor-associated antigens (TAAs) with a focus on antibody frequencies and the potential diagnostic, prognostic, and etiologic relevance of antibodies against TAAs. We performed a systematic literature search in Medline and identified 3,619 articles on humoral immune responses and TAAs. In 145 studies, meeting the inclusion criteria, humoral immune responses in cancer patients have been analyzed against over 100 different TAAs. The most frequently analyzed antigens were p53, MUC1, NY-ESO-1, c-myc, survivin, p62, cyclin B1, and Her2/neu. Antibodies against these TAAs were detected in 0–69% (median 14%) of analyzed tumor patients. Antibody frequencies were generally very low in healthy individuals, with the exception of few TAAs, especially MUC1. For several TAAs, including p53, Her2/neu, and NY-ESO-1, higher antibody frequencies were reported when tumors expressed the respective TAA. Antibodies against MUC1 were associated with a favorable prognosis while antibodies against p53 were associated with poor disease outcome. These data suggest different functional roles of endogenous antibodies against TAAs. Although data on prediagnostic antibody levels are scarce and antibody frequencies for most TAAs are at levels precluding use in diagnostic assays for cancer early detection, there is some promising data on achieving higher sensitivity for cancer detection using panels of TAAs.

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Metadata

Authors
Reuschenbach, M., von Knebel Doeberitz, M., & Wentzensen, N.
Venue
Cancer Immunology, Immunotherapy
Publisher
Springer Science and Business Media LLC
Published
2009-06-28
Volume
58
Issue
10
Pages
1535-1544
ISSN
  • 0340-7004 (ISSN-L)
  • 1432-0851
DOI
10.1007/s00262-009-0733-4
OpenAlex
W1987908689
Cited by
280
References
75
FWCI
0.97
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: A systematic review of humoral immune responses against tumor antigens. https://app.cochat.ai/papers/10.1007/s00262-009-0733-4
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Reuschenbach, M., von Knebel Doeberitz, M., & Wentzensen, N. (2009). A systematic review of humoral immune responses against tumor antigens. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-009-0733-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.