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Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance

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Manser, Angela R., Uhrberg, Markus·2016·Cancer Immunology, Immunotherapy

DOI 10.1007/s00262-015-1750-0PMC PMC11028690

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Abstract

A key feature of human natural killer (NK) cells, which enables efficient recognition of infected and malignant target cells, is the expression of HLA class I-specific receptors of the KIR and NKG2 gene families. Cell-to-cell variability in receptor expression leads to the formation of complex NK cell repertoires. As outlined here, NK cells go through major changes from newborns to adults characterized by downregulation of the inhibitory NKG2A receptor and concomitant upregulation of KIR family members. This process is completed in young adults, and in the majority of individuals, KIR/NKG2A repertoires remain remarkably stable until old age. Nonetheless, age-related factors have the potential to majorly influence the complexity of NK cell repertoires: Firstly infection with HCMV is associated with major clonal expansions of terminally differentiated NKG2C- and KIR-expressing NK cells in certain individuals. Secondly, ineffective hematopoiesis can lead to immature and less diversified NK cell repertoires as observed in myelodysplastic syndrome (MDS), a malignant disease of the elderly. Thus, whereas in the majority of elderly the NK cell compartment appears to be highly stable in terms of function and phenotype, in a minority of subjects a breakdown of NK cell repertoire diversity is observed that might influence immune surveillance and healthy aging.

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Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J., Lanier, L., & Spies, T. (1999) · Science · doi:10.1126/science.285.5428.727 · Cited by 3,272
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Braud, V. M., Allan, D., O'Callaghan, C. A., Söderström, K., D’Andrea, A., Ogg, G. S., Lazetic, S., Young, N. T., Bell, J. I., Phillips, J. H., et al. (1998) · Nature · doi:10.1038/35869 · Cited by 2,226
Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
Cooper, M. A., Fehniger, T. A., Turner, S. C., Chen, K. S.-M., Ghaheri, B. A., Ghayur, T., Carson, W. E., & Caligiuri, M. A. (2001) · Blood · doi:10.1182/blood.v97.10.3146 · Cited by 1,448
ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.
Cosman, D., Müllberg, J., Sutherland, C. L., Chin, W. A., Armitage, R., Fanslow, W., Kubin, M., & Chalupny, N. (2001) · Immunity · doi:10.1016/s1074-7613(01)00095-4 · Cited by 1,394
Licensing of natural killer cells by host major histocompatibility complex class I molecules
Kim, S., Poursine‐Laurent, J., Truscott, S. M., Lybarger, L. P., Song, Y.-J., Yang, L., French, A. R., Sunwoo, J. B., Lemieux, S., Hansen, T. H., et al. (2005) · Nature · doi:10.1038/nature03847 · Cited by 1,328
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Imai, K., Matsuyama, S., Miyaké, S., Suga, K., & Nakachi, K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03231-1 · Cited by 1,189

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Authors: Manser, A. R., & Uhrberg, M.
Affiliations: Heinrich Heine University Düsseldorf (DE)
Corresponding author: Uhrberg, Markus
ORCID: Uhrberg, Markus
Venue: Cancer Immunology, Immunotherapy
Publisher: Springer Science and Business Media LLC
Published: 2015-08-19
Volume: 65
Issue: 4
Pages: 417-426
ISSN: 0340-7004 (ISSN-L)
1432-0851
DOI: 10.1007/s00262-015-1750-0
PMC: PMC11028690
OpenAlex: W1837057295
Cited by: 148
References: 56
Citations by year: 2026: 19 · 2025: 14 · 2024: 28 · 2023: 19 · 2022: 10 · 2021: 15 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 1
FWCI: 3.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cancer Immunology Immunotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Krebshilfe (DE) (110351)
Deutsche Forschungsgemeinschaft (DE) (UH 91/7-1)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: natural killer cells, NK cell repertoire, aging, killer cell immunoglobulin-like receptors, NKG2A, NKG2C, HCMV infection, myelodysplastic syndrome, ineffective hematopoiesis, immune surveillance, healthy aging, clonal expansion
MeSH terms: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Child, Child, Preschool, Humans, Immunologic Surveillance, Infant, Infant, Newborn, Killer Cells, Natural, Middle Aged, Myelodysplastic Syndromes, Receptors, Natural Killer Cell

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Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance

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