Role of tumor microenvironment in tumorigenesis
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Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenvironment (TME) is closely connected to every step of tumorigenesis. Evidence suggests that the vital components of the TME are fibroblasts and myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory cells, the blood and lymphatic vascular networks, and ECM. This manuscript, based on the current studies of the TME, offers a more comprehensive overview of the primary functions of each component of the TME in cancer initiation, progression, and invasion. The manuscript also includes primary therapeutic targeting markers for each player, which may be helpful in treating tumors.
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Complex components of the tumor microenvironment can significantly affect the growth and metastasis of cancer via mechanical and biochemical factors.
“Various studies have demonstrated that complex components can significantly affect the growth and metastasis of cancer via mechanical and biochemical factors113–116.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [114]
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- Authors
- Wang, M., Zhao, J., Zhang, L., Wei, F., Lian, Y., Wu, Y., Gong, Z., Zhang, S., Zhou, J., Cao, K., Li, X., Xiong, W., Li, G., Zeng, Z., & Guo, C.
- Affiliations
- Central South University (CN)
- Corresponding author
- Zeng, Zhaoyang
- ORCID
- Venue
- Journal of Cancer
- Publisher
- Ivyspring International Publisher
- Published
- 2017
- Volume
- 8
- Issue
- 5
- Pages
- 761-773
- ISSN
- 1837-9664 (ISSN-L)
- PMC
- PMC5381164
- OpenAlex
- W2591628935
- Cited by
- 1,404
- References
- 278
- Citations by year
- 2026: 49 · 2025: 88 · 2024: 140 · 2023: 180 · 2022: 217 · 2021: 235 · 2020: 229 · 2019: 163 · 2018: 78 · 2017: 23 · 2015: 1
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Cancer (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81301757, 81472531, 81672683, 81672993, 81572787, 81372907, 81402009)
- Central South University
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- tumor microenvironment, carcinogenesis, tumor initiation, tumor progression, metastasis, extracellular matrix, tumor stromal cells, cancer-associated fibroblasts, myofibroblasts, tumor-infiltrating immune cells, tumor vasculature, therapeutic target
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