Cited by 1,404Cancer Cells and MetastasisTGF-β signaling in diseasesImmune cells in cancer

Role of tumor microenvironment in tumorigenesis

Open access
Wang, Maonan, Zhao, Jingzhou, Zhang, Lishen, Wei, Fang, Lian, Yu, Wu, Yingfeng, Gong, Zhaojian, Zhang, Shanshan +7 more·2017·Journal of Cancer

Abstract

Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenvironment (TME) is closely connected to every step of tumorigenesis. Evidence suggests that the vital components of the TME are fibroblasts and myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory cells, the blood and lymphatic vascular networks, and ECM. This manuscript, based on the current studies of the TME, offers a more comprehensive overview of the primary functions of each component of the TME in cancer initiation, progression, and invasion. The manuscript also includes primary therapeutic targeting markers for each player, which may be helpful in treating tumors.

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Crossref · 10.7150/jca.17648

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  • Complex components of the tumor microenvironment can significantly affect the growth and metastasis of cancer via mechanical and biochemical factors.

    “Various studies have demonstrated that complex components can significantly affect the growth and metastasis of cancer via mechanical and biochemical factors113–116.”

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Research works printed but not linked: 3

  1. [178]Gilbert CA Slingerland JM Cytokines, Obesity, and Cancer: New Insights on Mechanisms Linking Obesity to Cancer Risk and Progression Annu Rev Med 2013 64 45 57 23121183
  2. [225]Gout S Huot J Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer Cancer Microenviron 2008 1 69 83 19308686 PMC2654352
  3. [255]Zhou YJ Liao QJ Li XY HYOU1, Regulated by LPLUNC1, Is Up-Regulated in Nasopharyngeal Carcinoma and Associated with Poor Prognosis J Cancer 2016 7 367 76 26918051 PMC4749358

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Authors
Wang, M., Zhao, J., Zhang, L., Wei, F., Lian, Y., Wu, Y., Gong, Z., Zhang, S., Zhou, J., Cao, K., Li, X., Xiong, W., Li, G., Zeng, Z., & Guo, C.
Affiliations
Central South University (CN)
Corresponding author
Zeng, Zhaoyang
Venue
Journal of Cancer
Published
2017
Volume
8
Issue
5
Pages
761-773
ISSN
1837-9664 (ISSN-L)
OpenAlex
W2591628935
Cited by
1,404
References
278
Citations by year
2026: 49 · 2025: 88 · 2024: 140 · 2023: 180 · 2022: 217 · 2021: 235 · 2020: 229 · 2019: 163 · 2018: 78 · 2017: 23 · 2015: 1
FWCI
14.16
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Journal of Cancer (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81301757, 81472531, 81672683, 81672993, 81572787, 81372907, 81402009)
  • Central South University
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
tumor microenvironment, carcinogenesis, tumor initiation, tumor progression, metastasis, extracellular matrix, tumor stromal cells, cancer-associated fibroblasts, myofibroblasts, tumor-infiltrating immune cells, tumor vasculature, therapeutic target

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