The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Enhanced Recovery After Surgery (ERAS) Program Attenuates Stress and Accelerates Recovery in Patients After Radical Resection for Colorectal Cancer: A Prospective Randomized Controlled Trial
Abstract
Background: The aim of this trial was to compare the Enhanced Recovery After Surgery (ERAS) program with conventional perioperative management in patients who underwent radical resection for colorectal cancer. Methods: A combination of evidence‐based and consensus methodology was used to develop the ERAS protocol. Five hundred ninety‐seven consecutive patients who underwent elective colorectal resection were randomized to either the ERAS (n = 299) or the control group (n = 298). Outcomes relating to nutrition and metabolism index, stress index, and recovery index were measured and recorded. Results: Demographic and operative data were similar between the two groups. Patients in the ERAS group showed improved nutritional status when compared with those of the control group. On postoperative day (POD) 1, the HOMA‐IR (insulin resistance index) of the ERAS group was lower than that of the control group (p < 0.001). The cortisol level of the control group was elevated on both POD 1 (p = 0.007) and POD 5 (p = 0.002) compared to the preoperative level. However, the cortisol level of the ERAS group was not increased until POD 5 (p = 0.001). Reduced levels of TNF‐α, IL‐1β, IL‐6, and IFN‐γ in the ERAS group indicated less postoperative stress responses. In addition, ERAS was associated with accelerated recovery of gastrointestinal function. The postoperative length of stay (p < 0.001) and expense (p < 0.001) for the ERAS group were reduced in comparison to the controls. Twenty‐eight cases in the control group and twenty‐nine in the ERAS group suffered complications, which was not significantly different. Conclusion: The ERAS protocol attenuates the surgical stress response and accelerates postoperative recovery without compromising patient safety.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lewis, S. J., Egger, M., Sylvester, P. A., & Thomas, S. (2001) · BMJ · doi:10.1136/bmj.323.7316.773 · Cited by 858
Preoperative fasting for adults to prevent perioperative complications
Brady, M. C., Kinn, S., Stuart, P., & Ness, V. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004423 · Cited by 694 · cited 1×
“However, several recent studies have found that providing carbohydrates 2 h before surgery could reduce preoperative thirst, hunger, and anxiety and significantly reduce postoperative insulin resistance and hospital stay, with no increase in the risk of aspiration or regurgitation [9, 10].”
Background
Cited by
(2015) · Annals of Surgery · doi:10.1097/sla.0000000000001029 · Cited by 621
Exploiting the critical perioperative period to improve long-term cancer outcomes
Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.224 · Cited by 487
Systematic review and meta-analysis of enhanced recovery programmes in surgical patients
Nicholson, A., Lowe, M. C., Parker, J., Lewis, S. R., Alderson, P., & Smith, A. F. (2014) · British Journal of Surgery · doi:10.1002/bjs.9394 · Cited by 476
Zhuang, C.-L., Ye, X.-Z., Zhang, X.-D., Chen, B.-C., & Yu, Z. (2013) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0b013e3182812842 · Cited by 458
Temple-Oberle, C., Shea-Budgell, M. A., Tan, M., Semple, J. L., Schrag, C., Barreto, M., Blondeel, P., Hamming, J., Dayan, J., & Ljungqvist, O. (2017) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000003242 · Cited by 361
Metadata
- Authors
- Ren, L., Zhu, D., Wei, Y., Pan, X., Liang, L., Xu, J., Zhong, Y., Xue, Z., Jin, L., Zhan, S., Niu, W., Qin, X., Wu, Z., & Wu, Z.
- Venue
- World Journal of Surgery
- Publisher
- Wiley
- Published
- 2011-11-19
- Volume
- 36
- Issue
- 2
- Pages
- 407-414
- ISSN
- 0364-2313 (ISSN-L)
- 1432-2323
- OpenAlex
- W2131146665
- Cited by
- 234
- References
- 2
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Enhanced Recovery After Surgery (ERAS) Program Attenuates Stress and Accelerates Recovery in Patients After Radical Resection for Colorectal Cancer: A Prospective Randomized Controlled Trial. https://app.cochat.ai/papers/10.1007/s00268-011-1348-4
- The paper
- Ren, L., Zhu, D., Wei, Y., Pan, X., Liang, L., Xu, J., Zhong, Y., Xue, Z., Jin, L., Zhan, S., Niu, W., Qin, X., Wu, Z., & Wu, Z. (2012). Enhanced Recovery After Surgery (ERAS) Program Attenuates Stress and Accelerates Recovery in Patients After Radical Resection for Colorectal Cancer: A Prospective Randomized Controlled Trial. World Journal of Surgery. https://doi.org/10.1007/s00268-011-1348-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
