Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine
Open accessAbstract
Purpose Chemoneuropathy remains a painful, burdensome complication of cancer treatment for patients receiving a range of chemotherapeutics, yet the cause and persistence of this condition are not fully documented. This study was designed to quantify the longevity of and contributions to neuropathy following treatment with the plant alkaloids paclitaxel and vincristine.Methods Quantitative sensory testing was conducted approximately 18 months apart on 14 patients, seven of which had been treated with paclitaxel and seven with vincristine and compared to data from 18 healthy control subjects. In addition, skin biopsies were obtained to investigate changes in the density of Meissner's corpuscles and epidermal nerve fibers (ENFs), the loss of which is thought to contribute to multiple forms of neuropathy.Results Impairments in motor skills, as measured by a grooved peg-board, were found. Deficits in touch detection were observed using von Frey monofilaments, as were changes in sharpness detection using a weighted needle device. Using a Peltier device, warmth and heat detection were impaired. These deficits were consistent across time. Remarkably, the average length of time patients reported painful neuropathy was over four and a half years. Skin biopsies were found to be deficient in Meissner's corpuscles and ENFs.Conclusions The combination of widespread deficits in sensory testing and decreases in skin innervation for cancer patients receiving paclitaxel or vincristine document a persistent polyneuropathy which severely impacts these patients. Decreases in Meissner's corpuscles and ENFs indicate a possible mechanism for the neuropathy.
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Patients with CIPN experience symptoms of neuropathic pain such as paraesthesia, dysesthesia, allodynia, and hyperalgesia, in addition to numbness.
“Patients with CIPN experience symptoms of neuropathic pain such as paraesthesia, dysesthesia, allodynia, and hyperalgesia, in addition to numbness (Boyette-Davis et al, 2013).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Boyette-Davis et al, 2013
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Cites
Taxol stabilizes microtubules in mouse fibroblast cells.
Schiff, P. B., & Horwitz, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1561 · Cited by 1,971 · see citing works
Oxaliplatin: mechanism of action and antineoplastic activity.
Raymond, É., Faivre, S. J., WOYNAROWSKI, J. M., & Chaney, S. G. (1998) · PubMed · Cited by 520 · see citing works
Ruff, R. M., & Parker, S. B. (1993) · Perceptual and Motor Skills · doi:10.2466/pms.1993.76.3c.1219 · Cited by 490 · see citing works
Quantitation of epidermal nerves in diabetic neuropathy
Kennedy, W. R., Wendelschafer‐Crabb, G., & Johnson, T. (1996) · Neurology · doi:10.1212/wnl.47.4.1042 · Cited by 434 · see citing works
Self-citationDougherty, P. M., Cata, J. P., Cordella, J. V., Burton, A., & Weng, H. (2004) · Pain · doi:10.1016/j.pain.2004.01.021 · Cited by 371 · see citing works
Self-citationSiau, C., Xiao, W. H., & BENNETT, G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.05.007 · Cited by 302 · see citing works
Oaklander, A. L. (2001) · Pain · doi:10.1016/s0304-3959(00)00481-4 · Cited by 233 · see citing works
Lobert, S., Vulevic, B., & Correia, J. J. (1996) · Biochemistry · doi:10.1021/bi953037i · Cited by 214 · see citing works
Boyette-Davis, J. A., Xin, W., Zhang, H., & Dougherty, P. M. (2010) · Pain · doi:10.1016/j.pain.2010.10.030 · Cited by 202 · see citing works
Self-citationPeters, C. M., Jiménez‐Andrade, J. M., Kuskowski, M. A., Ghilardi, J. R., & Mantyh, P. W. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.066 · Cited by 175 · see citing works
Cutaneous Innervation Density in the Allodynic Form of Postherpetic Neuralgia
Rowbotham, M. C., Yosipovitch, G., Connolly, M. K., Finlay, D. R., Forde, G., & Fields, H. L. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0021 · Cited by 174 · see citing works
Toxic neuropathy in patients with pre-existing neuropathy
Chaudhry, V., Chaudhry, M. A., Crawford, T. O., Simmons-OʼBrien, E., & Griffin, J. W. (2003) · Neurology · doi:10.1212/01.wnl.0000043691.53710.53 · Cited by 173 · see citing works
Cata, J. P., Weng, H., Lee, B., Reuben, J. M., & Dougherty, P. M. (2006) · PubMed · Cited by 171 · see citing works
Self-citationQuantitative Sensory Findings in Patients With Bortezomib-Induced Pain
Cata, J. P., Weng, H., Burton, A. W., et al. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.09.014 · Cited by 162 · see citing works
Self-citationLong term effects of vincristine on the peripheral nervous system
Postma, T. J., Benard, B. A., Huijgens, P. C., et al. (1993) · Journal of Neuro-Oncology · doi:10.1007/bf01050259 · Cited by 151 · see citing works
Intraepidermal nerve fiber density in rat foot pad: neuropathologic–neurophysiologic correlation
Lauria, G., Lombardi, R., Borgna, M., et al. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.0010210.x · Cited by 148 · see citing works
Boyette-Davis, J. A., & Dougherty, P. M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.019 · Cited by 132 · see citing works
Self-citationPignata, S., Placido, S. D., Biamonte, R., et al. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-5 · Cited by 116 · see citing works
Longitudinal assessment of oxaliplatin-induced neuropathy
Burakgazi, A. Z., Messersmith, W. A., Vaidya, D. M., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31822cfc59 · Cited by 107 · see citing works
Dougherty, P. M., Cata, J. P., Burton, A. W., Vu, K., & Weng, H. (2007) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2006.08.006 · Cited by 105 · see citing works
Self-citationSpinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia
Weng, H., Aravindan, N., Cata, J. P., Chen, J.-H., Shaw, A., & Dougherty, P. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.049 · Cited by 99 · see citing works
Self-citationFollow-Up Psychophysical Studies in Bortezomib-Related Chemoneuropathy Patients
Boyette-Davis, J. A., Cata, J. P., Zhang, H., et al. (2011) · Journal of Pain · doi:10.1016/j.jpain.2011.04.008 · Cited by 90 · see citing works
Self-citationNatural history of cutaneous innervation following herpes zoster
Petersen, K. L., Rice, F. L., Farhadi, M., et al. (2010) · Pain · doi:10.1016/j.pain.2010.04.002 · Cited by 86 · see citing works
Argyriou, A. A., Polychronopoulos, P., Iconomou, G., et al. (2007) · Acta Oncologica · doi:10.1080/02841860701355055 · Cited by 84 · see citing works
Progressive paresthesias after cessation of therapy with very high-dose cisplatin
Grunberg, S. M., Sonka, S., Stevenson, L. L., et al. (1989) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00694340 · Cited by 82 · see citing works
Secondary hyperalgesia persists in capsaicin desensitized skin
Fuchs, P. N., Campbell, J. N., & Meyer, R. A. (2000) · Pain · doi:10.1016/s0304-3959(99)00194-3 · Cited by 80 · see citing works
Miyano, K., Tang, H., Nakamura, Y., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.04.001 · Cited by 42 · see citing works
New opioid side effects and implications for long-term therapy
Raghavan, S., Harvey, A., & Humble, S. R. (2010) · Trends in Anaesthesia and Critical Care · doi:10.1016/j.cacc.2010.06.003 · Cited by 22 · see citing works
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Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
- Authors
- Boyette-Davis, J. A., Cata, J. P., Driver, L. C., Novy, D. M., Bruel, B. M., Mooring, D. L., Wendelschafer-Crabb, G., Kennedy, W. R., & Dougherty, P. M.
- Affiliations
- York College of Pennsylvania (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Minnesota (US)
- Corresponding author
- Dougherty, Patrick M.
- Venue
- Cancer Chemotherapy and Pharmacology
- Published
- 2012-12-11
- Volume
- 71
- Issue
- 3
- Pages
- 619-626
- ISSN
- 0344-5704 (ISSN-L)
- 1432-0843
- PMC
- PMC3581748
- OpenAlex
- W1981358093
- Cited by
- 148
- References
- 29
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 8 · 2023: 11 · 2022: 16 · 2021: 10 · 2020: 13 · 2019: 10 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 8 · 2013: 2
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cancer Chemotherapy and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA124787., P01CA124787, P30CA016672)
- National Institute of Neurological Disorders and Stroke (NS 046606, R01NS046606)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- paclitaxel, vincristine, plant alkaloids, polyneuropathy, Meissner corpuscles, epidermal nerve fibers, skin innervation, quantitative sensory testing, chemotherapy side effects, sensory impairment
- MeSH terms
- Aged, Antineoplastic Agents, Phytogenic, Biopsy, Female, Humans, Male, Mechanoreceptors, Middle Aged, Motor Skills, Nerve Fibers, Pain, Pain Measurement, Peripheral Nervous System Diseases, Physical Stimulation, Pilot Projects, Sensory Thresholds, Skin, Thermosensing, Touch, Vincristine, Paclitaxel, Neurotoxicity Syndromes
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