The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Biocompatibility of implants: lymphocyte/macrophage interactions
Abstract
The monocyte-derived macrophage is recognized as a critical determinant in biocompatibility, but its appearance in the chronic inflammatory phase is accompanied by the presence of lymphocytes, which have been much less studied in this regard. Here, we first present an overview of the physiologic continuum comprising host reactions to the surgical implantation of biomaterial. Secondly, we describe our collective research efforts, which indicate that lymphocytes are additional and key cellular determinants of biocompatible outcome. Thus, bioengineering advances will require that lymphocyte responses be regarded as integral components of innate inflammatory and immune/immunotoxic cell interactions at sites of biomaterial implantation.
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“Likewise, Th2 lymphocyte derived signals such as IL-4 and IL-13 direct M2 polarization of macrophages that in turn produce chemokines such as CCL17, CCL22 and CCL24, which enhance the recruitment of Th2 lymphocytes [68].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [68]
In the citing paper
“In addition to the well-established role of macrophages in response to implanted biomaterials, emerging research suggests that lymphocytes are key cellular determinants of biomaterial outcomes [68].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [68]
In the citing paper
“TH1 lymphocytes release IFN-g which polarizes cells toward an M1 phenotype, secreting several pro-inflammatory cytokines and chemokines, some of which (IL-12, CXCL-10) escalate the inflammatory response by recruiting more Th1 lymphocytes [68,69].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [68]
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Self-citation
Research works printed but not linked: 4
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Metadata
- Authors
- Anderson, J. M., & McNally, A. K.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Anderson, James M.
- ORCID
- Anderson, James M.
- Venue
- Seminars in Immunopathology
- Published
- 2011-01-27
- Volume
- 33
- Issue
- 3
- Pages
- 221-233
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W2036077057
- Cited by
- 226
- References
- 109
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 17 · 2022: 16 · 2021: 19 · 2020: 34 · 2019: 18 · 2018: 14 · 2017: 13 · 2016: 18 · 2015: 22 · 2014: 13 · 2013: 10 · 2012: 14
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Seminars in Immunopathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (EB 00282)
- Topics
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Keywords
- implant biocompatibility, lymphocytes, macrophages, monocyte-derived macrophages, biomaterial implantation, host immune response, chronic inflammation, immunotoxicity, innate immunity, macrophage-lymphocyte interaction
- MeSH terms
- Animals, Biocompatible Materials, Cell Communication, Humans, Inflammation, Lymphocytes, Macrophages, Wound Healing, Prostheses and Implants
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