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Cited by 40Antibiotic Resistance in BacteriaBacterial Identification and Susceptibility TestingBacterial Genetics and Biotechnology

Effect of androgens and glucocorticoids on microbial growth and antimicrobial susceptibility

Plotkin, Balbina J., Roose, Robert J., Erikson, Quenby, Viselli, Susan M.·2003·Current Microbiology
DOI 10.1007/s00284-003-4080-y
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Abstract

The effects of androgens, testosterone and dihydrotestosterone (DHT), of an environmental anti-androgen, 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (DDE), and of glucocorticoids, hydrocortisone and dexamethasone, on growth kinetics and antibiotic susceptibility of E. faecalis, E. coli, P. aeurginosa, and S. aureus were measured. For P. aeurginosa, the presence of either DHT or DDE caused at least a fourfold shift in the minimum inhibitory concentration (MIC) of cefepime and tobramycin. DHT and DDE also affected the response of E. faecalis to meropenem and norfloxacin, resulting in a shift from sensitive to intermediate resistance (four-fold increase in MIC). Hydrocortisone (2 microM) induced an increase in the sensitivity of S. aureus to erythromycin, as compared to hormone-free control (from 0.5 to 0.06 microg/mL). The susceptibility pattern of E. coli was unaffected by the hormones tested. These changes in susceptibility to antibiotics were unrelated to alterations in growth kinetics. For all organisms tested, the alterations in MICs occurred only in the presence of hormone, indicative of changes in the phenotype of these stable quality control strains.

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  • Growth promotion of bacteria is also seen with TNFα, interleukins 1, 6, and 8, and glucocorticoids.

    “as well as catecholamines, growth promotion is seen with TNFα, interleukins 1, 6, and 8, and glucocorticoids.”

    From The microbiome and critical illness (2016) · cites this paper as [125]

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Authors
Plotkin, B. J., Roose, R. J., Erikson, Q., & Viselli, S. M.
Affiliations
Midwestern University (US)
ORCID
Plotkin, Balbina J.
Venue
Current Microbiology
Publisher
Springer Science and Business Media LLC
Published
2003-12
Volume
47
Issue
6
Pages
514-20
ISSN
  • 0343-8651 (ISSN-L)
  • 1432-0991
DOI
10.1007/s00284-003-4080-y
OpenAlex
W2001014873
Cited by
40
References
39
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 4 · 2012: 1
FWCI
0.34
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
androgens, glucocorticoids, testosterone, dihydrotestosterone, DDE, cortisol, dexamethasone, antimicrobial susceptibility, minimum inhibitory concentration, bacterial growth kinetics, Escherichia faecalis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, cefepime, tobramycin, meropenem, norfloxacin, erythromycin, antibiotic resistance, androgen receptor antagonists
MeSH terms
Androgens, Anti-Bacterial Agents, Bacteria, Dichlorodiphenyl Dichloroethylene, Dexamethasone, Escherichia coli, Glucocorticoids, Hydrocortisone, Microbial Sensitivity Tests, Phenotype, Pseudomonas aeruginosa, Dihydrotestosterone, Staphylococcus aureus, Enterococcus faecalis, Testosterone, Drug Resistance, Bacterial

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