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Cited by 11

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Usefulness of noninvasive diagnostic procedures for assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis

Frankowski, Marek, Świerkot, Jerzy, Gomułkiewicz, Marek, Korman, Lucyna, Skoczyńska, Marta, Starba, Aleksandra·2022·Rheumatology International
DOI 10.1007/s00296-021-05059-zPMC PMC8940880
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Abstract

Methotrexate (MTX) is recommended as a first-line treatment for rheumatoid arthritis (RA). There are no strict guidelines regarding monitoring for liver damage in RA patients. This study aimed to evaluate noninvasive diagnostic procedures in assessing liver fibrosis in RA patients. Ninety-six RA patients were recruited for this study. The procollagen III N-terminal peptide (PIIINP) serum level was measured in all patients. The Enhanced Liver Fibrosis score (ELF-1) was calculated for 82 patients. Transient elastography (TE) was performed in 91 patients, those examined were divided into two groups: a study and control group, comprising patients with and without risk factors for liver fibrosis, respectively. The TE result correlated only with the body mass index—BMI (p < 0.05); there was no correlation with the cumulative MTX dose (p = 0.33). The TE result was significantly higher in those with risk factors for liver fibrosis than in those without risk factors (TE result > = 7.1 kPa 28/42 vs 13/41, HR = 2.103, Mann–Whitney U test, approximately 0.02). There was a positive correlation between the PIIINP level and body weight (p = 0.028), cumulative MTX dose (p = 0.007), RA activity (p = 0.028) and diabetes mellitus (DM) (p = 0.001). There was a positive correlation between the ELF-1 score and age (p < 0.001), cumulative MTX dose (p = 0.007) and RA activity (p < 0.001). The PIIINP level and ELF-1 score are not organ specific, and readings may vary depending on RA activity. TE is organ specific and can be performed by a skilled ultrasonographer might be useful to assess actual liver condition.

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Fig. 1 Transient elastography result depending on the presence of risk factors (Statistica ver. 10.0)
Fig. 1 Transient elastography result depending on the presence of risk factors (Statistica ver. 10.0)CC BY · PubMed Central

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Metadata

Authors
Frankowski, M., Świerkot, J., Gomułkiewicz, M., Korman, L., Skoczyńska, M., & Starba, A.
ORCID
Venue
Rheumatology International
Publisher
Springer Science and Business Media LLC
Published
2021-12-06
Volume
42
Issue
4
Pages
631-638
ISSN
  • 0172-8172
  • 1437-160X
DOI
10.1007/s00296-021-05059-z
PMC
PMC8940880
Cited by
11
References
30
Language
en
Licence
Funders
Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu (STM.A270.20.111)

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