Transient elastography (FibroScan ® ) with controlled attenuation parameter in the assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease - Where do we stand?
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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Currently, the routinely used modalities are unable to adequately determine the levels of steatosis and fibrosis (laboratory tests and ultrasonography) or cannot be applied as a screening procedure (liver biopsy). Among the non-invasive tests, transient elastography (FibroScan(®), TE) with controlled attenuation parameter (CAP) has demonstrated good accuracy in quantifying the levels of liver steatosis and fibrosis in patients with NAFLD, the factors associated with the diagnosis and NAFLD progression. The method is fast, reliable and reproducible, with good intra- and interobserver levels of agreement, thus allowing for population-wide screening and disease follow-up. The initial inability of the procedure to accurately determine fibrosis and steatosis in obese patients has been addressed with the development of the obese-specific XL probe. TE with CAP is a viable alternative to ultrasonography, both as an initial assessment and during follow-up of patients with NAFLD. Its ability to exclude patients with advanced fibrosis may be used to identify low-risk NAFLD patients in whom liver biopsy is not needed, therefore reducing the risk of complications and the financial costs.
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With VCTE, liver stiffness measurement and controlled attenuation parameter values are determined which allow for a relatively reliable estimation of the degree of fibrosis and steatosis, respectively.
“With the vibration-controlled transient elastography (VCTE), liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) values are determined which allow for a relatively reliable estimation of the degree of fi brosis and steatosis, respectively.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [151]
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- Authors
- Mikolasevic, I., Orlic, L., Franjic, N., Hauser, G., Stimac, D., & Milic, S.
- Affiliations
- University of Rijeka (HR)
- ORCID
- Hauser, Goran
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2016
- Volume
- 22
- Issue
- 32
- Pages
- 7236
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4997649
- OpenAlex
- W2509438375
- Cited by
- 273
- References
- 131
- Citations by year
- 2026: 18 · 2025: 31 · 2024: 27 · 2023: 35 · 2022: 28 · 2021: 38 · 2020: 36 · 2019: 29 · 2018: 19 · 2017: 11
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- transient elastography, controlled attenuation parameter, non-alcoholic fatty liver disease, hepatic steatosis, liver fibrosis, noninvasive fibrosis assessment, NAFLD screening, obesity, liver biopsy alternative, disease progression
- MeSH terms
- Humans, Liver, Obesity, Metabolic Syndrome, Elasticity Imaging Techniques, Non-alcoholic Fatty Liver Disease
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