Diffusion-weighted MRI of soft tissue tumours
Abstract
The purpose of this study was to evaluate the clinical utility of a multi-shot spin-echo echo-planar (SE-EPI) diffusion-weighted sequence in the diagnostic work-up of soft tissue tumours. There were 29 patients, 16 with a benign lesion and 13 with a sarcoma. Four of the sarcomas were examined both before and after radiation therapy. Diffusion-weighted imaging was performed with a multi-shot SE-EPI sequence. The b values were 0 and 600 s/mm(2). Phase navigation and pulse trigging were applied. The apparent diffusion constant (ADC) value of a large region of interest (ROI) representing the lesion was measured and compared to diagnosis and treatment. The ADC values of the benign lesions (mean 1.8 x 10(-3) mm(2)/s) overlapped with non-treated sarcomas (mean 1.7 x 10(-3) mm(2)/s). The ADC value increased in all radiated sarcomas. A multi-shot SE-EPI diffusion imaging sequence of less than 2-min duration is technically feasible in soft tissue tumours of the extremities and the trunk. The ADC values of benign soft tissue tumours and sarcomas overlapped and could not be used to differentiate between the bulk of benign and malignant tumours. However, the increase in ADC values of soft tissue sarcomas after radiotherapy warrants further studies of diffusion imaging for evaluating therapy response.
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In a previous study, ADC values in desmoid tumours (range 1.2-1.9 × 10-3/mm2/s) and nodular fasciitis (1.1 and 2.3 × 10-3/mm2/s) were higher compared to ADC values in AWE.
“In a previous study, ADC values in desmoid tumours (range: 1.2–1.9 × 10–3/mm2/s) and nodular fasciitis (1.1 and 2.3 × 10–3/mm2/s) [25] were higher compared to ADC values in AWE.”
From Appearance of abdominal wall endometriosis on MR imaging (2010) · cites this paper as [25]
Cites
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Appearance of abdominal wall endometriosis on MR imaging
Busard, M. P. H., Mijatovic, V., van Kuijk, C., Hompes, P. G. A., & van Waesberghe, J. H. T. M. (2010) · European Radiology · doi:10.1007/s00330-009-1658-1 · Cited by 79 · see citing works
“3×10/mm(2)/s) [25] were higher compared to ADC values in AWE.”
Background
- Authors
- Einarsd�ttir, H., Karlsson, M., Wejde, J., & Bauer, H. C. F.
- Affiliations
- Karolinska University Hospital (SE)
- Venue
- European Radiology
- Published
- 2004-06-01
- Volume
- 14
- Issue
- 6
- Pages
- 959-963
- ISSN
- 0938-7994 (ISSN-L)
- 1432-1084
- OpenAlex
- W1970601452
- Cited by
- 199
- References
- 12
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 14 · 2020: 4 · 2019: 8 · 2018: 16 · 2017: 15 · 2016: 9 · 2015: 14 · 2014: 12 · 2013: 6 · 2012: 7
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Radiology (publishedVersion)
- PubMed (publishedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Keywords
- diffusion-weighted imaging, soft tissue tumor, soft tissue sarcoma, benign soft tissue lesions, apparent diffusion coefficient, radiotherapy response, treatment response assessment
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Sarcoma, Soft Tissue Neoplasms, Diffusion Magnetic Resonance Imaging
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