Cited by 99Radiomics and Machine Learning in Medical ImagingBreast Cancer Treatment StudiesDigital Radiography and Breast Imaging

Intratumoral and peritumoral radiomics for preoperative prediction of neoadjuvant chemotherapy effect in breast cancer based on contrast-enhanced spectral mammography

Mao, Ning, Shi, Yinghong, Lian, Chun, Wang, Zhongyi, Zhang, Kun, Xie, Haizhu, Zhang, Haicheng, Chen, Qianqian +3 more·2022·European Radiology

Abstract

Objective To investigative the performance of intratumoral and peritumoral radiomics based on contrast-enhanced spectral mammography (CESM) to preoperatively predict the effect of the neoadjuvant chemotherapy (NAC) of breast cancers.Materials and methods A total of 118 patients with breast cancer who underwent preoperative CESM and NAC from July 2017 to June 2020 were retrospectively analyzed, and the patients were grouped into training (n = 81) and test sets (n = 37) according to the CESM examination time. NAC effect for each patient was assessed by pathology. Intratumoral and peritumoral radiomics features were extracted from CESM images, and feature selection was performed through the Mann-Whitney U test and least absolute shrinkage and selection operator regression (LASSO). Five radiomics signatures based on intratumoral regions, 5-mm peritumoral regions, 10-mm peritumoral regions, intratumoral regions + 5-mm peritumoral regions, and intratumoral regions + 10-mm peritumoral regions were calculated through a linear combination of selected features weighted by their respective coefficients. The prediction performance of radiomics signatures was assessed by the area under the receiver operator characteristic (ROC) curve, the precision-recall (P-R) curve, the calibration curve, and decision curve analysis (DCA).Results Ten radiomics features were selected to establish the radiomics signature of intratumoral regions + 5-mm peritumoral regions, which yielded a maximum AUC of 0.85 (95% CI, 0.72-0.98) in the test set. The calibration curves, P-R curves, and DCA showed favorable predictive performance of the five radiomics signatures.Conclusion The intratumoral and peritumoral radiomics based on CESM exhibited potential for predicting the NAC effect in breast cancer, which could guide treatment decisions.Key points • The intratumoral and peritumoral CESM-based radiomics signatures show good performance in predicting the NAC effect in breast cancer.

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Crossref · 10.1007/s00330-021-08414-7

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Authors
Mao, N., Shi, Y., Lian, C., Wang, Z., Zhang, K., Xie, H., Zhang, H., Chen, Q., Cheng, G., Xu, C., & Dai, Y.
Affiliations
  • Qingdao University (CN)
  • Peking University Shenzhen Hospital (CN)
Corresponding author
  • Xu, Cong
  • Dai, Yi
Venue
European Radiology
Published
2022-01-23
Volume
32
Issue
5
Pages
3207-3219
ISSN
  • 0938-7994 (ISSN-L)
  • 1432-1084
OpenAlex
W4206941699
Cited by
99
References
45
Citations by year
2026: 14 · 2025: 29 · 2024: 29 · 2023: 23 · 2022: 4
FWCI
12.09
Type
journal article
Language
en
Open access
closed
Locations
  • European Radiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (82001775, 61773244)
  • Taishan Scholar Foundation of Shandong Province (tsqn202103197)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Digital Radiography and Breast Imaging
Keywords
breast cancer, neoadjuvant chemotherapy response, radiomics, contrast-enhanced mammography, intratumoral region, peritumoral region, radiomics signature, preoperative prediction, treatment response prediction
MeSH terms
Breast Neoplasms, Female, Humans, Mammography, Retrospective Studies, Neoadjuvant Therapy

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