Testosterone stimulates myoglobin expression in different muscles of the mouse

Mänttäri, Satu; Anttila, Katja; Järvilehto, Matti

doi:10.1007/s00360-008-0280-x

Cited by 17Cardiovascular and exercise physiologyHormonal and reproductive studiesMuscle Physiology and Disorders

Testosterone stimulates myoglobin expression in different muscles of the mouse

Mänttäri, Satu, Anttila, Katja, Järvilehto, Matti·2008·Journal of Comparative Physiology B

DOI 10.1007/s00360-008-0280-x

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Abstract

The regulation of energy metabolism is one of the major functions of steroid hormones. This study was performed to explore whether testosterone can regulate the aerobic capacity of skeletal muscles via myoglobin expression. To study this, changes in testosterone level were quantified, and the level of myoglobin protein was analyzed using Western blot in mice subjected to 6 weeks of training (T) or testosterone administration (A). Both treatments significantly increased the plasma testosterone level when compared to the untrained (U) or control (C) group. Training induced a significant increase in the myoglobin content in gastrocnemius and plantaris muscles (287 and 83%, respectively). Testosterone administration increased myoglobin concentration in plantaris (183%) but not in gastrocnemius. In extensor digitorum longus muscle the protein content decreased slightly after exercise, but increased 78% after testosterone administration. In soleus and rectus femoris muscles the myoglobin content was unchanged after both treatments. The data show that testosterone and training have differential effects on the concentration of myoglobin in some, but not all muscles. This may have an influence on the aerobic capacity in mouse skeletal muscles. The data demonstrated that both testosterone administration and training induced an increase in plasma testosterone level. However, the effects of the treatments on the myoglobin concentration differ.

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Experimental evidence in mice shows that testosterone increases myoglobin content of muscle with potential for augmenting aerobic exercise performance, but this has not been evaluated in humans.
“Experimental evidence in mice shows that testosterone increases myoglobin content of muscle with potential for augmenting aerobic exercise performance (96), but this has not been evaluated in humans.”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [96]

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Authors: Mänttäri, S., Anttila, K., & Järvilehto, M.
Affiliations: University of Oulu (FI)
Corresponding author: Mänttäri, Satu
ORCID: Mänttäri, Satu
Anttila, Katja
Venue: Journal of Comparative Physiology B
Publisher: Springer Science and Business Media LLC
Published: 2008-06-12
Volume: 178
Issue: 7
Pages: 899-907
ISSN: 0174-1578 (ISSN-L)
1432-136X
DOI: 10.1007/s00360-008-0280-x
OpenAlex: W1978872103
Cited by: 17
References: 59
Citations by year: 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2012: 2
FWCI: 2.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Comparative Physiology B (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: testosterone, skeletal muscle, cardiorespiratory fitness, exercise training, plasma testosterone, gastrocnemius, plantaris, extensor digitorum longus, soleus muscle, rectus femoris, steroid hormones, energy metabolism
MeSH terms: Animals, Dose-Response Relationship, Drug, Male, Mice, Inbred Strains, Myoglobin, Testosterone, Myogenin, Muscle, Skeletal, Myosin Heavy Chains, Mice

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Testosterone stimulates myoglobin expression in different muscles of the mouse

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