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Cited by 214Dementia and Cognitive Impairment ResearchNutritional Studies and DietFatty Acid Research and Health

The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.

Diet, cognition, and Alzheimer’s disease: food for thought

Otaegui-Arrazola, Ane, Amiano, Pilar, Elbusto, Ana, Urdaneta, Elena, Martínez-Lage, Pablo·2014·European Journal of Nutrition
DOI 10.1007/s00394-013-0561-3
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Abstract

Introduction The prevention of Alzheimer's disease (AD) has become a real challenge due to its rising prevalence and the lack of an effective cure. Diet and nutrients have gained significant interest as potentially modifiable protective factors.Purpose The aim of this review is to provide an updated summary of evidence related to the effect of diet and nutritional factors on the risk of AD and cognitive aging, and discuss the potential mechanisms and confounding factors involved.Methods A search was conducted in Medline and Web of Knowledge for epidemiological and clinical studies in the international literature from January 2000 to February 2013 using combinations of the following keywords: "Alzheimer's disease", "mild cognitive impairment", "cognitive function", "dietary factors", "omega-3", "antioxidants", "B vitamins", "dietary patterns", and "Mediterranean diet".Results and conclusion Data from observational studies point to a protective role for certain nutrients, such as omega-3 fatty acids, antioxidants or B vitamins, and dietary patterns (Mediterranean diet). However, data from randomized controlled trials do not show a consistent effect. Whether confounding factors such as age, disease stage, other dietary components, cooking processes, and other methodological issues explain the divergent results remains to be established. Moreover, if certain nutrients protect against dementia, it is as yet unknown whether they may have a general effect on brain vascular health or directly interfere with the etiopathogenesis of AD.

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  1. Shah R, Kamphuis P, Leurgans S, Swinkels S, Sadowsky C, Bongers A, Rappaport S, Quinn J, Wieggers R, Bennett D, Scheltens P (2011) Souvenaid as an add-on intervention in patients with mild to moderate Alzheimer’s disease using Alzheimer’s disease medication: results from a randomized, controlled, double-blind study (S-Connect). J Nutr Health Aging 15(Suppl):1

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Metadata

Authors
Otaegui-Arrazola, A., Amiano, P., Elbusto, A., Urdaneta, E., & Martínez-Lage, P.
Affiliations
  • Fundacion CITA Alzheimer (ES)
  • Basque Government (ES)
  • Basque Culinary Center (ES)
Corresponding author
Otaegui-Arrazola, Ane
ORCID
Venue
European Journal of Nutrition
Publisher
Springer Science and Business Media LLC
Published
2013-07-27
Volume
53
Issue
1
Pages
1-23
ISSN
  • 1436-6207 (ISSN-L)
  • 1436-6215
DOI
10.1007/s00394-013-0561-3
OpenAlex
W2037420920
Cited by
214
References
212
Citations by year
2026: 2 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 16 · 2020: 25 · 2019: 21 · 2018: 22 · 2017: 21 · 2016: 15 · 2015: 29 · 2014: 13 · 2013: 3
FWCI
2.73
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eusko Jaurlaritza
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
Alzheimer's disease, diet, nutrition, cognitive aging, dementia prevention, omega-3 fatty acids, antioxidants, B vitamins, Mediterranean diet, dietary habits, mild cognitive impairment, confounding factors
MeSH terms
Aging, Alzheimer Disease, Antioxidants, Cognition, Diet, Humans, Vitamin B Complex, Meta-Analysis as Topic, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Dietary Supplements, Observational Studies as Topic

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