Cited by 925Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsNuclear Receptors and Signaling

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

Open access

Holmqvist, Staffan, Chutna, Oldriska, Bousset, Luc, Aldrin-Kirk, Patrick, Li, Wen, Björklund, Tomas, Wang, Zhan-You, Roybon, Laurent, Melki, Ronald, Li, Jia-Yi·2014·Acta Neuropathologica

DOI 10.1007/s00401-014-1343-6

Open this paper in CoChat — free account

Abstract

The cellular hallmarks of Parkinson's disease (PD) are the loss of nigral dopaminergic neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the remaining neurons. Based on the topographic distribution of Lewy bodies established after autopsy of brains from PD patients, Braak and coworkers hypothesized that Lewy pathology primes in the enteric nervous system and spreads to the brain, suggesting an active retrograde transport of α-synuclein (the key protein component in Lewy bodies), via the vagal nerve. This hypothesis, however, has not been tested experimentally thus far. Here, we use a human PD brain lysate containing different forms of α-synuclein (monomeric, oligomeric and fibrillar), and recombinant α-synuclein in an in vivo animal model to test this hypothesis. We demonstrate that α-synuclein present in the human PD brain lysate and distinct recombinant α-synuclein forms are transported via the vagal nerve and reach the dorsal motor nucleus of the vagus in the brainstem in a time-dependent manner after injection into the intestinal wall. Using live cell imaging in a differentiated neuroblastoma cell line, we determine that both slow and fast components of axonal transport are involved in the transport of aggregated α-synuclein. In conclusion, we here provide the first experimental evidence that different α-synuclein forms can propagate from the gut to the brain, and that microtubule-associated transport is involved in the translocation of aggregated α-synuclein in neurons.

Integrity signals

Registry

Crossref · 10.1007/s00401-014-1343-6

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Microtubules as a target for anticancer drugs
Jordan, M. A., & Wilson, L. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1317 · Cited by 4,000
Mobility measurement by analysis of fluorescence photobleaching recovery kinetics
Axelrod, D., Koppel, D. E., Schlessinger, J., Elson, E. L., & Webb, W. W. (1976) · Biophysical Journal · doi:10.1016/s0006-3495(76)85755-4 · Cited by 2,717
Stages in the development of Parkinson’s disease-related pathology
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
Li, J.-Y., Englund, E., Holton, J. L., Soulet, D., Hagell, P., Lees, A. J., Lashley, T., Quinn, N. P., Rehncrona, S., Björklund, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1746 · Cited by 1,845
Self-citation
Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., & Olanow, C. W. (2008) · Nature Medicine · doi:10.1038/nm1747 · Cited by 1,722
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
Braak, H., R�b, U., Gai, W. P., & Del Tredici, K. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0808-2 · Cited by 1,683
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
Desplats, P., Lee, H.-J., Bae, E.-J., Patrick, C., Rockenstein, E., Crews, L., Spencer, B., Masliah, E., & Lee, S.-J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903691106 · Cited by 1,485
In vivo demonstration that α-synuclein oligomers are toxic
Winner, B., Jappelli, R., Maji, S. K., Desplats, P. A., Boyer, L., Aigner, S., Hetzer, C., Loher, T., Vilar, M., Campioni, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100976108 · Cited by 1,463

Show all 51 references

Sorted by citations

Items 601–700 of 925

Effect of bacteriophage-encoded chaperonins on amyloid transformation of α-synuclein
Leisi, E. V., Barinova, K. V., Kudryavtseva, S. S., Moiseenko, A. V., Muronetz, V. I., & Kurochkina, L. P. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.07.015 · Cited by 10
Dendritic cells in Parkinson's disease: Regulatory role and therapeutic potential
Mula, A. R. A., Yuan, X., & Lu, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176690 · Cited by 9
FLZ attenuates Parkinson's disease pathological damage by increasing glycoursodeoxycholic acid production via down-regulating Clostridium innocuum
Shang, M., Ning, J., Zang, C., Ma, J., Yang, Y., Jiang, Y., Chen, Q., Dong, Y., Wang, J., Li, F., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.011 · Cited by 9
Gut neuropeptide involvement in Parkinson’s disease
Templeton, H., Tobet, S. A., & Schwerdtfeger, L. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2024 · Cited by 11
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Sulatsky, M. I., Stepanenko, O. V., Stepanenko, O. V., & Sulatskaya, A. I. (2025) · Aggregate · doi:10.1002/agt2.70078 · Cited by 9
Efficacy of gut microbiota-targeted therapies in Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
Gu, X. Q., Tang, J., & Chen, C. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1627406 · Cited by 9
La maladie de Parkinson est-elle une maladie à prion ?
Brandel, J., Corbillé, A.-G., Derkinderen, P., & Haı̈k, S. (2015) · Revue Neurologique · doi:10.1016/j.neurol.2015.10.005 · Cited by 13
Parkinson’s disease. Focus on early stages
Катунина, Е. А., Zalyalova, Z. A., Похабов, Д. В., Ivanova, M. Z. I., & Semenova, A. M. (2023) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2023-3-95-103 · Cited by 12
Could the Urease of the Gut Bacterium Proteus mirabilis Play a Role in the Altered Gut–Brain Talk Associated with Parkinson’s Disease?
Grahl, M. V. C., Andrade, B. D. S., Perin, A. P. A., Neves, G. A., Duarte, L. D. S., Uberti, A. F., Hohl, K. S., Follmer, C., & Carlini, C. R. (2023) · Microorganisms · doi:10.3390/microorganisms11082042 · Cited by 12
Insights into Calpain Activation and Rho-ROCK Signaling in Parkinson’s Disease and Aging
Gathings, A., Zaman, V., Banik, N. L., & Haque, A. (2024) · Biomedicines · doi:10.3390/biomedicines12051074 · Cited by 9
Enteric Neurodegeneration is Mediated Through Independent Neuritic and Somal Mechanisms in Rotenone and MPP+ Toxicity
Virga, D. M., Capps, J., & Vohra, B. P. S. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2649-x · Cited by 10
Gastrectomy, vitamin B12 supplementation and the risk of Parkinson's disease: A nationwide cohort study
Choi, Y. J., Choi, I. Y., Jang, W., Jeong, S., Park, S. H., Han, K., Lee, Y., Lee, D. H., & Shin, D. W. (2021) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2020.12.026 · Cited by 9
Body-first Parkinson’s disease and variant Creutzfeldt–Jakob disease – similar or different?
Woerman, A. L., & Tamgüney, G. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105625 · Cited by 8
Deciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseases
Yoshida, S., & Hasegawa, T. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105307 · Cited by 9
The effect of electroacupuncture at ST25 on Parkinson's disease constipation through regulation of autophagy in the enteric nervous system
Song, L.-Z.-X., Xu, N., Yu, Z. H., Yang, H., Xu, C., Qiu, Z., Dai, J., Xu, B., & Hu, X. (2023) · The Anatomical Record · doi:10.1002/ar.25148 · Cited by 9
Donepezil for Constipation in Lewy Body Diseases: Four Case Studies
Lepkowsky, C. M. (2017) · Activitas Nervosa Superior · doi:10.1007/s41470-017-0004-1 · Cited by 9
The Microbiome in Neurodegenerative Disease
Brown, E. G., Tanner, C. M., & Goldman, S. M. (2018) · Current Geriatrics Reports · doi:10.1007/s13670-018-0240-6 · Cited by 10
Mechanisms Underlying the Interaction Between Chronic Neurological Disorders and Microbial Metabolites via Tea Polyphenols Therapeutics
Hong, M., Cheng, L., Liu, Y., Wu, Z., Zhang, P., & Zhang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.823902 · Cited by 9
The interrelationship between intestinal immune cells and enteric α-synuclein in the progression of Parkinson’s disease
Cheng, Y.-K., & Chiang, H.-S. (2025) · Neurological Sciences · doi:10.1007/s10072-025-08114-w · Cited by 8
Microbiome: A Key Regulator of Body-Brain Interactions
O’Riordan, K. J., Aburto, M. R., Nagpal, J. K., Clarke, G. A., & Cryan, J. F. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_6 · Cited by 9
LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model
Kong, W.-X., Zhang, Z., Li, S., Zhu, S., Li, C., Dong, X., Gan, T.-T., Hu, D., Liang, F.-C., Xu, P., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03502-7 · Cited by 8
Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment
Zang, Z., Yang, F., Qu, L., Ge, M., Tong, L., Xue, L., Sun, X., & Hai, Y. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1640389 · Cited by 8
Food Contamination: An Unexplored Possible Link between Dietary Habits and Parkinson’s Disease
Caioni, G., Cimini, A., & Benedetti, E. (2022) · Nutrients · doi:10.3390/nu14071467 · Cited by 9
Differential interactions of α-synuclein conformers affect refolding and activity of proteins
Bagree, G., Srivastava, T., Mahasivam, S., Sinha, M., Bansal, V., Ramanathan, R., Priya, S., & Sharma, S. (2022) · The Journal of Biochemistry · doi:10.1093/jb/mvac095 · Cited by 9
Disease mechanisms as subtypes: Microbiome
Bonvegna, S., & Cilia, R. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85555-6.00006-0 · Cited by 8
Etiology and Pathogenesis of Parkinson’s Disease
Timpka, J., Cenci, M. A., & Odin, P. (2017) · Springer eBooks · doi:10.1007/978-3-7091-1628-9_10 · Cited by 8
FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation
Svanbergsson, A., Ek, F., Martinsson, I., Rodo, J., Liu, D., Brandi, E., Haikal, C., Torres-Garcia, L., Li, W., Gouras, G. K., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01070-1 · Cited by 8
Self-citation
Transcutaneous vagus nerve stimulation (tVNS) as a potential therapeutic application for neurodegenerative disorders – A focus on dysautonomia in Parkinson's disease
Ko, D. W. K. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102858 · Cited by 8
Microbiota–Gut–Brain Axis: Pathophysiological Mechanism in Neuropsychiatric Disorders
Shin, C., & Kim, Y. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_2 · Cited by 10
Oral biomarkers in exercise‐induced neuroplasticity in Parkinson's disease
Mougeot, J., Hirsch, M. A., Stevens, C. B., & Mougeot, F. K. B. (2016) · Oral Diseases · doi:10.1111/odi.12463 · Cited by 8
The raphe nuclei are the early lesion site of gastric α-synuclein propagation to the substantia nigra
Zhang, C., Bo, R., Zhou, T., Chen, N., & Yuan, Y. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.01.015 · Cited by 7
Activation of α7nAch receptors ameliorates α-synuclein pathology in the brain and gut of a subacute MPTP mouse model of Parkinson's disease
Leem, Y., Park, J., Park, J., Kim, D., Park, J.-M., Kim, S., Kang, J. L., & Kim, H.-S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117871 · Cited by 7
Microbiota-Immune System Interactions in Human Neurological Disorders
Huang, Q., Fang, Y., Liao, D., & Xia, J. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200726222138 · Cited by 7
Association between microbiological risk factors and neurodegenerative disorders: An umbrella review of systematic reviews and meta-analyses
Wang, X., Jiang, D., Li, T., Zhang, X. L., Wang, R., Gao, S., Yang, F., Wang, Y., Tian, Q., Xie, C., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.991085 · Cited by 7
The role of gut-derived short-chain fatty acids in Parkinson's disease
Saadh, M. J., Mustafa, A. N., Mustafa, M. A., Renuka Jyothi, S., Dabis, H. K., Prasad, G. V. S., Mohammad, I. J., Adnan, A., & Idan, A. H. (2024) · Neurogenetics · doi:10.1007/s10048-024-00779-3 · Cited by 9
Neurosonological Findings Related to Non-Motor Features of Parkinson’s Disease: A Systematic Review
Pérez, C. D. T., Amaya‐Pascasio, L., Padillo, A. A., Romero, J. O., Olmedo, M. V. M., Pérez, J. F., Ortiz, M. P., & Martínez‐Sánchez, P. (2021) · Brain Sciences · doi:10.3390/brainsci11060776 · Cited by 7
Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine
Ohlsson, L., Isaxon, C., Wrighton, S., Ouahidi, W. E., Fornell, L., Uller, L., Ansar, S., & Voss, U. (2022) · Physiological Reports · doi:10.14814/phy2.15249 · Cited by 6
Targeting the Gut–Brain Axis with Fecal Microbiota Transplantation: Considerations on a Potential Novel Treatment for Parkinson's Disease
Contarino, M. F., van Hilten, J. J., & Kuijper, E. J. (2022) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13621 · Cited by 7
Mesenchymal stem-cell-derived microvesicles ameliorate MPTP-induced neurotoxicity in mice: a role of the gut–microbiota–brain axis
Pu, Y., Wu, Q., Zhang, Q., Huang, T., Wen, J., Wei, L., Hashimoto, K., & Liu, Y. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06348-0 · Cited by 7
Experimental models of gut‐first Parkinson's disease: A systematic review
Videlock, E. J., Xing, T., Yehya, A. H. S., & Travagli, R. A. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14604 · Cited by 9
Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights
Prieto, I., Segarra, A. B., Martínez‐Cañamero, M., de Gasparo, M., Zórad, Š., & Ramírez‐Sánchez, M. (2017) · Endocrine Regulations · doi:10.1515/enr-2017-0017 · Cited by 7
Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human α-Synuclein: Comparison with Dopaminergic and Serotonergic Denervation
Finberg, J. P. M., Aluf, Y., Loboda, Y., Nakhleh, M. K., Jeries, R., Abud-Hawa, M., Zubedat, S., Avital, A., Khatib, S., Vaya, J., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00318 · Cited by 7
Role of Microbiota in Neurodegenerative Diseases
Sobol, C. V. (2018) · Russian Journal of Developmental Biology · doi:10.1134/s1062360418060061 · Cited by 7
Characterization of the Basic Membrane Properties of Neurons of the Rat Dorsal Motor Nucleus of the Vagus in Paraquat-Induced Models of Parkinsonism
Bove, C., Coleman, F. H., & Travagli, R. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.08.048 · Cited by 7
Appendectomy Does Not Increase the Risk of Future Emergence of Parkinson’s Disease: A Meta-analysis
Ishizuka, M., Shibuya, N., Takagi, K., Hachiya, H., Tago, K., Suda, K., Aoki, T., & Kubota, K. (2021) · The American Surgeon · doi:10.1177/0003134821989034 · Cited by 7
The Neural Gut–Brain Axis of Pathological Protein Aggregation in Parkinson’s Disease and Its Counterpart in Peroral Prion Infections
Beekes, M. (2021) · Viruses · doi:10.3390/v13071394 · Cited by 7
Predictive Value of Gut Microbiome for Cognitive Impairment in Patients with Hypertension
Lu, S., Shao, L., Zhang, Y., Yang, Y., Wang, Z., Zhang, B., Yu, J. Z., Xu, Q., Wang, S., Chen, X., et al. (2021) · Disease Markers · doi:10.1155/2021/1683981 · Cited by 7
Self-citation
Gastrointestinal dysfunction in Parkinson's disease
Timpka, J., & Odin, P. (2021) · International review of movement disorders · doi:10.1016/bs.irmvd.2021.07.004 · Cited by 7
The Oral–Gut–Brain Axis: From Periodontal Dysbiosis to Neuroinflammation—Mechanistic Pathways, Salivary and Intestinal Biomarkers, and Therapeutic Targets: A Narrative Review
Dumitru, C. N., Dumitru, A. O., Popa, G. V., Marcu, T., Ursu, M., Nechita, A., & Matei, N. M. (2026) · Dentistry Journal · doi:10.3390/dj14050289 · Cited by 6
“Systemic LPS, derived from the increased intestinal permeability described above, activates cerebral endothelial TLR4, inducing local production of inflammatory mediators and recruitment of peripheral immune cells into the CNS [77,80].”
Influential
The ketogenic diet in Parkinson’s disease: a potential therapeutic strategy
Pokora, B., Pokora, K., Binienda, A., & Fichna, J. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00799-2 · Cited by 9
Effects of antimicrobial exposure on the risk of Parkinson's disease
Pal, G. D., Bennett, L., Roy, J. A., Nyandege, A. N., Mouradian, M. M., Gerhard, T., & Horton, D. B. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.107081 · Cited by 6
Probiotics in Health and Immunity: A First Step toward Understanding the Importance of Microbiota System in Translational Medicine
Isacco, C. G., Ballini, A., Vito, D. D., Inchingolo, A. M., Cantore, S., Paduanelli, G., Nguyen, K. C. D., Inchingolo, A. D., Dipalma, G., & Inchingolo, F. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88601 · Cited by 7
Disease modifying therapies for Parkinson's disease: Novel targets
Vijiaratnam, N., & Foltynie, T. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108839 · Cited by 6
Non-Reproducibility of Oral Rotenone as a Model for Parkinson’s Disease in Mice
Niederberger, E., Wilken‐Schmitz, A., Manderscheid, C., Schreiber, Y., Gurke, R., & Tegeder, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012658 · Cited by 6
Dysfunction of the noradrenergic system drives inflammation, α-synucleinopathy, and neuronal loss in mouse colon
Song, S., Tu, D., Meng, C., Liu, J., Wilson, B. C., Wang, Q., Shih, Y. I., Gao, H., & Hong, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1083513 · Cited by 7
Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus
van der Keylen, P., Garreis, F., Steigleder, R., Sommer, D. D., Neuhuber, W., & Wörl, J. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-015-1403-6 · Cited by 6
Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation
Hu, Q. Z., Hong, M., Huang, M., Gong, Q., Zhang, X., Uversky, V. N., Pan-Montojo, F. J., Huang, T., Zhou, H., & Zhu, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00917-6 · Cited by 7
Factors Affecting Pathological Amyloid Protein Transformation: From Post-Translational Modifications to Chaperones
Muronets, V. I., Kudryavtseva, S. S., Kurochkina, L. P., Leisi, E. V., Stroylova, Y. Y., & Schmalhausen, E. V. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297924604003 · Cited by 5
Dairy-rich diet triggers hepatic α-synuclein pathology via the liver-brain axis in GBA1-related Parkinson’s disease
Chen, Y., Ma, M., Zhang, R., Guo, C., Ding, X., Wang, J., Qin, C., Feng, R., Meng, H., Wu, H., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01211-9 · Cited by 5
The Brain‐Gut Axis in Parkinson's Disease Pathology
Ozkaya, K. S., & Browning, K. N. (2026) · Comprehensive physiology · doi:10.1002/cph4.70137 · Cited by 6
In Vitro Cell Model Investigation of Alpha-Synuclein Aggregate Morphology Using Spectroscopic Imaging
Swaminathan, P., Klingstedt, T., Theologidis, V., Gram, H., Larsson, J. N. K., Hagen, L., Liabakk, N., Gederaas, O. A., Hammarström, P., Nilsson, K. P. R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212458 · Cited by 5
Probiotic: A Gut Microbiota-Based Therapeutic Approaches for the Treatment of Parkinson’s Disease
Rout, M., Prusty, S. K., & Kar, D. M. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328332572241219102122 · Cited by 5
Ultrasound imaging of vagus nerves in patients with Parkinson's disease
Чечеткин, А. О., Николаевна, М. А., Fedotova, E. Y., & Illarioshkin, S. N. (2021) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2021.054 · Cited by 5
Colonic Myenteric Plexus Neurodegeneration and Minor Colon Inflammation in Trimethyltin-induced Rat Model of Neurodegeneration
Septyaningtrias, D. E., Zulfa, H. A., Ramadhani, M. F., Sumaryati, Sulistyawati, D., Paramita, D. K., Sumiwi, Y. A. A., & Susilowati, R. (2023) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554231182195 · Cited by 5
Gut Microbes: The Gut Brain Connection
Lynch, C. M. K., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-46712-7_4 · Cited by 5
Diagnostik des klinischen und prodromalen idiopathischen Parkinson-Syndroms
Zach, H., Walter, U., Liepelt‐Scarfone, I., & Maetzler, W. (2017) · Der Nervenarzt · doi:10.1007/s00115-017-0290-6 · Cited by 5
Past appendectomy may be related to early cognitive dysfunction in Parkinson’s disease
Goncalves, A. R., Mendes, A., Vila‐Chã, N., Damásio, J., Fernandes, J., & Cavaco, S. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04507-1 · Cited by 5
Animal models of synucleinopathies and how they could impact future drug discovery and delivery efforts
Jellinger, K. A. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1638908 · Cited by 6
Microbiota-Gut-Brain Axis
Szablewski, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00065-6 · Cited by 5
Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and menPreprint
Gries, M., Christmann, A., Schulte, S., Weyland, M., Rommel, S., Martin, M., Baller, M. K., Röth, R., Schmitteckert, S., Unger, M. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.06.136556 · Cited by 5
Safety and feasibility of fecal microbiota transplantation for Parkinson’s disease patients: a protocol for a self-controlled interventional donor-FMT pilot studyPreprint
Vendrik, K. E. W., Chernova, V. O., Kuijper, E. J., Terveer, E. M., van Hilten, J. J., & Contarino, M. F. (2022) · medRxiv · doi:10.1101/2022.05.23.22274942 · Cited by 5
Dysfunctional digestive tract highlights the metabolic hallmarks of nanoplastic-exacerbated Parkinson’s pathology
Liang, X., Wang, Y., Andrikopoulos, N., Ke, P. C., & Li, Y. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01145-2 · Cited by 5
Neuromodulation influences T lymphocyte calcium signaling and alpha synuclein clearance: implications for Parkinson’s disease
Ross, A., Prowse, N. A., Zhang, H., Hayley, S. P., & Hongyu, S. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1627305 · Cited by 4
Parkinson’s disease beyond the brain: implications for treatments
Naeini, S. M., Lopez, M. D., Fraser, P. E., & Tandon, A. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1600782 · Cited by 4
Could it be that neurodegenerative diseases are infectious?
Derkinderen, P. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.07.003 · Cited by 4
Comprehensive integrated overview of the experimental and clinical neuroprotective effect of astaxanthin
Abdelaziz, A. I., Gad, A. M., & Azab, S. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823304-7.00012-x · Cited by 4
MICROBIOTA INTESTINAL RELACIONADA A DOENÇA DE PARKINSON
da Silva, C. F., Azevedo, G. E., & Taketani, N. F. (2021) · Revista Ensaios Pioneiros · doi:10.24933/rep.v5i1.235 · Cited by 4
Genetic modifiers of synucleinopathies—lessons from experimental models
Lee, R. M. Q., & Koh, T. (2023) · Oxford Open Neuroscience · doi:10.1093/oons/kvad001 · Cited by 4
The Poly-Arginine Peptide R18D Interferes with the Internalisation of α-Synuclein Pre-Formed Fibrils in STC-1 Enteroendocrine Cells
Gorecki, A. M., Spencer, H. L., Meloni, B. P., & Anderton, R. S. (2023) · Biomedicines · doi:10.3390/biomedicines11082089 · Cited by 4
Gut Microbes in Parkinson's Disease
Markidi, A., Elford, J. D., Berkers, C. R., Kraneveld, A. D., & Perez‐Pardo, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00002-3 · Cited by 4
Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids
Mirab, F., Pirhaghi, M., Otzen, D. E., & Saboury, A. A. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167862 · Cited by 4
Cutting the vagal highway blocks one point of entry for prion‐like alpha‐synuclein
Kaufmann, H. (2015) · Annals of Neurology · doi:10.1002/ana.24492 · Cited by 4
Parkinson's disease and prion disease: Straining the comparison
Fung, V. S. C., & Kordower, J. H. (2015) · Movement Disorders · doi:10.1002/mds.26437 · Cited by 4
Parkinson’s Disease and Aging
Andersen, J. K., & Chinta, S. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_8 · Cited by 4
Blood-Derived α-Synuclein Aggregated in the Substantia Nigra of Parabiotic Mice
Ma, X., Chen, L., Song, N., Qu, L., Wang, J., & Xie, J. (2021) · Biomolecules · doi:10.3390/biom11091287 · Cited by 4
Potential Role of Probiotics and Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease
El‐Mansoury, B., Smimih, K., Khiat, A. E., Fatimi, H. E., Aimrane, A., Baz, S. E., Elmourid, A., Saad, F. E.-Z., Ghachi, H. E., Khanouchi, M., et al. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5156-4.ch017 · Cited by 4
Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson’s disease
Sadoc, M., Clairembault, T., Coron, E., Berthomier, C., Dily, S. L., Vavasseur, F., Pavageau, A., Louis, E. K. S., Péréon, Y., Neunlist, M., et al. (2023) · SLEEP · doi:10.1093/sleep/zsad310 · Cited by 5
Struktur und Efferenzen der Substantia nigra pars compacta beim idiopathischen Parkinson-Syndrom
Urban, P. P., Falkenburger, B. H., Jost, W. H., Ransmayr, G. N., Riederer, P. F., & Winkler, C. (2020) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-1149-9280 · Cited by 4
INFLAMMATORY BOWEL DISEASE INDUCES α-SYNUCLEIN AGGREGATION IN GUT AND BRAINPreprint
Espinosa‐Oliva, A. M., Ruiz, R., Soto, M. S., Boza‐Serrano, A., Rodriguez-Perez, A. I., Roca-Ceballos, M. A., García‐Revilla, J., Santiago, M., Serres, S., Economopoulus, V., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.26.477259 · Cited by 4
Immune dysregulation and gut microbiota: Connection to health and disease development
Boleti, A. P. D. A., Cardoso, P. H. D. O., Frihling, B. E. F., de Moraes, L. F. R. N., Nunes, E. A. C., Mukoyama, L. T. H., Biembengute, M. E. F., Melo, V. F., Morales, M., de Castro, A. P., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00244 · Cited by 4
Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: implications for Parkinson’s disease pathogenesis
Menozzi, E., Geiger, M., Meslier, V., Fierli, F., Gilles, M., Chau, K., David, A., Golan, R. S., Famechon, A., Koletsi, S., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1546203 · Cited by 3
Therapeutic role of probiotics in motor and non-motor symptoms of Parkinson’s disease
Páez‐García, S., Hernández-Triana, D., Salazar, F. E., Barreto, G. E., Rodríguez-Oroz, M. C., & Borda, M. G. (2025) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2025.1004129 · Cited by 3
The APOA1-SNCA Axis as a Molecular Bridge Between CKD and Parkinson’s Disease: A Systems Biology Model of Kidney-to-Brain Propagation via Exosomal Pathways
Billur, D., Hanagasi, H. A., Bılgıç, B., & Timirci‐Kahraman, Ö. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104176 · Cited by 3
Potential Role of Probiotics on Gut Microbiota in Neurological Disease
Jose, J. V., & Aliya, S. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-4530-4_10 · Cited by 3
PD-Like Pathogenesis in Caenorhabditis elegans Intestinally Infected with Nocardia farcinica and the Underlying Molecular Mechanisms
Liu, W., Zhou, W., Zhao, P., Wu, T., Gu, H., Li, Y., Zhong, C., Bai, H., Zhao, N., & Huang, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04076-w · Cited by 3
Cytotoxicity of α-synuclein amyloid fibrils generated with phage chaperonin OBP
Pozdyshev, D. V., Leisi, E. V., Muronetz, V. I., Golyshev, S. A., & Kurochkina, L. P. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151127 · Cited by 3
Intracellular Inclusions Induced by Patient-Derived and Amplified α-Synuclein Aggregates Are Morphologically Indistinguishable
Al‐Lahham, R., Corkins, M. E., Ishtikhar, M., Rabadia, P., Ramírez, S., Banerjee, V., & Shahnawaz, M. (2025) · Cells · doi:10.3390/cells14100684 · Cited by 3
Fecal Microbiota Transplants as a Treatment Option for Parkinson’s Disease
Flameling, I. A., & Rijkers, G. T. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.78666 · Cited by 3
Microbiota-Gut-Brain Axis in Neurological Disorders
Sundaram, S., Ponnambath, D. K., & Nair, S. S. (2022) · Springer eBooks · doi:10.1007/978-981-16-7672-7_7 · Cited by 4
The Role of Gut Microbiota in the Progression of Parkinson’s Disease and the Mechanism of Intervention by Traditional Chinese Medicine
Huan, P.-F., Wang, L., He, Z.-Q., & He, J. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s367016 · Cited by 3

Authors: Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Li, W., Björklund, T., Wang, Z.-Y., Roybon, L., Melki, R., & Li, J.-Y.
Affiliations: Lund University (SE)
Centre National de la Recherche Scientifique (FR)
Northeastern University (CN)
ORCID: Holmqvist, Staffan
Bousset, Luc
Aldrin-Kirk, Patrick
Li, Wen
Björklund, Tomas
Wang, Zhan-You
Roybon, Laurent
Melki, Ronald
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 2014-10-09
Volume: 128
Issue: 6
Pages: 805-820
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/s00401-014-1343-6
OpenAlex: W1995281235
Cited by: 925
References: 51
Citations by year: 2026: 47 · 2025: 67 · 2024: 73 · 2023: 67 · 2022: 110 · 2021: 132 · 2020: 102 · 2019: 107 · 2018: 75 · 2017: 59 · 2016: 43 · 2015: 38 · 2014: 3
FWCI: 30.94
Type: journal article
Language: en
Open access: green
lup.lub.lu.se
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Acta Neuropathologica (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Lund University Publications (Lund University) (submittedVersion, other-oa)
Funders: Agence Nationale de la Recherche (ANR-11-BSV8-0021)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, alpha-synuclein, Lewy bodies, gut-brain axis, vagus nerve, retrograde transport, enteric nervous system, dorsal motor nucleus of the vagus, axonal transport, alpha-synuclein aggregation, rat model
MeSH terms: Animals, Axonal Transport, Brain, Disease Models, Animal, Humans, Parkinson Disease, Recombinant Proteins, Vagus Nerve, Rats, Sprague-Dawley, Disease Progression, Gastrointestinal Tract, Cell Line, Tumor, alpha-Synuclein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks