Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
Abstract
Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body-like inclusions that stained positively for alpha-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.
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Previous evidence suggested prion-like cell-to-cell transmission of α-synuclein.
“Previous evidence suggested “prion-like” cell-to-cell transmission of α-synuclein9,10.”
From Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration (2020) · cites this paper as [9]
In post-mortem studies of PD patients with intrastriatal grafts, 1-5% of grafted dopaminergic neurons exhibited detectable LRP 12-22 years post-transplantation.
“These studies showed that 1-5% of the grafted dopaminergic neurons exhibited detectable LRP 12-22 years post-transplantation (n=2 patients [205], n=1 patient [206], n=3 patients [207]), which increased to 11-12% after 24 years (n=1 patient [208]).”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [206]
The most widely cited studies in support of the prion-like spread of LRP come from post-mortem studies of two PD patient cohorts who received robust long-term intrastriatal grafts of human fetal midbrain tissue.
“The most widely cited studies in support of the prion-like spread of LRP comes from post-mortem studies of two PD patient cohorts who received robust long-term intrastriatal grafts of human fetal midbrain tissue [205–208].”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [206]
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“Kordower reported very similar results in his other case report, published in a 2008 edition of Nature Medicine (Kordower et al., 2008a).”
BackgroundResultInfluentialAnimal modeling an oligodendrogliopathy – multiple system atrophy
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- Authors
- Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., & Olanow, C. W.
- Affiliations
- Rush University Medical Center (US)
- University of South Florida (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Kordower, Jeffrey H
- Venue
- Nature Medicine
- Published
- 2008-04-06
- Volume
- 14
- Issue
- 5
- Pages
- 504-506
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2044407202
- Cited by
- 1,722
- References
- 13
- Citations by year
- 2026: 58 · 2025: 69 · 2024: 75 · 2023: 57 · 2022: 118 · 2021: 108 · 2020: 131 · 2019: 116 · 2018: 98 · 2017: 115 · 2016: 92 · 2015: 85 · 2014: 85 · 2013: 119 · 2012: 95
- FWCI
- 62.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, Lewy body-like inclusions, alpha-synuclein, ubiquitin, dopamine transporter, striatum, cell therapy, substantia nigra
- MeSH terms
- Female, Humans, Immunohistochemistry, Middle Aged, Parkinson Disease, Substantia Nigra, Fetal Tissue Transplantation, Brain Tissue Transplantation, Lewy Bodies, Treatment Outcome, Disease Progression, Ubiquitin, alpha-Synuclein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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