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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

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SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease

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Sex as a Determinant of Age-Related Changes in the Brain

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Ketamine Regulates Phosphorylation of CRMP2 To Mediate Dendritic Spine Plasticity

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Neurodegenerative disorders share common features of “loss of function” states of a proposed mechanism of nervous system functions

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Impaired Synaptic Plasticity Mechanisms in Alzheimer’s Disease

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Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction

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Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice

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Differential regulations of neural activity and survival in primary cortical neurons by PFOA or PFHpA

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Volume of hippocampal subfields and cognitive deficits in neuromyelitis optica spectrum disorders

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Tau proteins and senescent Cells: Targeting aging pathways in Alzheimer’s disease

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Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

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Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?

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Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease

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Firing rate homeostasis counteracts changes in stability of recurrent neural networks caused by synapse loss in Alzheimer’s disease

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Modulation of AβPP and GSK3β by Endoplasmic Reticulum Stress and Involvement in Alzheimer’s Disease

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Guanosine Neuroprotection of Presynaptic Mitochondrial Calcium Homeostasis in a Mouse Study with Amyloid-β Oligomers

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Neuroprotective Effects of Tripeptides—Epigenetic Regulators in Mouse Model of Alzheimer’s Disease

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Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease

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Impact of Pharmacological and Non-Pharmacological Modulators on Dendritic Spines Structure and Functions in Brain

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Astrogliosis, neuritic microstructure, and sex effects: GFAP is an indicator of neuritic orientation in women

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Cognitive integrity in Non‐Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines

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Decreased 5‐HT1A binding in mild Alzheimer's disease—A positron emission tomography study

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Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle?

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Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer’s disease pathology

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α7 nicotinic ACh receptors are necessary for memory recovery and neuroprotection promoted by attention training in amyloid‐β‐infused mice

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The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ1–42 on Megf10-Dependent Astrocytic Synapse Elimination and Spine Density in Ex Vivo Hippocampal Brain Slices

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Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?

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Dendritic spines and their role in the pathogenesis of neurodevelopmental and neurological disorders

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Amyloid Beta and Tau: from Physiology to Pathology in Alzheimer’s Disease

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Golgi-Cox impregnation combined with fluorescence staining of amyloid plaques reveals local spine loss in an Alzheimer mouse model

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Exploring Dendritic and Spine Structural Profiles in Epilepsy: Insights From Human Studies and Experimental Animal Models

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Alteration of synaptic protein composition during developmental synapse maturation

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β-amyloid’s neurotoxic mechanisms as defined by in vitro microelectrode arrays: a review

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Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer’s Disease Mice

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Gene expression of serotonergic markers in peripheral blood mononuclear cells of patients with late-onset Alzheimer's disease

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Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure

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Actions of the TrkB Agonist Antibody ZEB85 in Regulating the Architecture and Synaptic Plasticity in Hippocampal Neurons

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Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain

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Amyloid-β-activated microglia can induce compound proteinopathies

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Astrocyte-microglia crosstalk in the hippocampus mediates cognitive impairments induced by chronic intermittent hypoxia

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Role of Oxygen Radicals in Alzheimer’s Disease: Focus on Tau Protein

Atlante, A., Valenti, D., Latina, V., & Amadoro, G. (2021) · Oxygen · doi:10.3390/oxygen1020010 · Cited by 11

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models

Yao, H. K., Mazza, F., Prévot, T. D., Sibille, E. L., & Hay, E. (2025) · iScience · doi:10.1016/j.isci.2025.112136 · Cited by 12

Aging and Alzheimer’s: the critical role of mitochondrial dysfunction and synaptic alterations

Pinky, Wali, Z., Neha, Tiwari, P., El‐Tanani, M., Rabbani, S. A., & Parvez, S. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2025.1676317 · Cited by 11

Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome

Speranza, L., Filiz, K. D., Goebel, S., Perrone‐Capano, C., Pulcrano, S., Volpicelli, F., & Francesconi, A. (2022) · Biomedicines · doi:10.3390/biomedicines10112692 · Cited by 11

Microstructural Tissue Changes in Alzheimer Disease Brains: Insights from Magnetization Transfer Imaging

Colonna, I., Koini, M., Pirpamer, L., Damulina, A., Hofer, E., Schwingenschuh, P., Enzinger, C., Schmidt, R., & Ropele, S. (2021) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6975 · Cited by 10

Integrative Human Genetic and Cellular Analysis of the Pathophysiological Roles of AnxA2 in Alzheimer’s Disease

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Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers

Arriagada, J., Mercerón‐Martínez, D., Ardiles, Á. O., Muñoz, P., & Paula-Lima, A. C. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151133 · Cited by 9

Monoterpenes and Diterpenes in Combating Alzheimer Disease, Mechanisms, and Clinical Insights: A Comprehensive Review

Hadipour, E., Shahangian, S. S., & Mashayekhi, F. (2024) · Caspian Journal of Neurological Sciences · doi:10.32598/cjns.10.36.460.1 · Cited by 9

Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways

Ongnok, B., Prathumsap, N., Chunchai, T., Pantiya, P., Arunsak, B., Chattipakorn, N., & Chattipakorn, S. C. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04145-0 · Cited by 9

Profiling of long non-coding RNAs in hippocampal–entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer’s disease

Liu, H., Li, J., Wang, X., Luo, S., Luo, D., Ge, W., & Ma, C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03083-x · Cited by 9

Deficiency of adaptive immunity does not interfere with Wallerian degeneration

Cashman, C. R., & Höke, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177070 · Cited by 9

ALWPs Improve Cognitive Function and Regulate Aβ Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer’s Disease

Nam, Y., Joo, B., Lee, J., Han, K., Ryu, K., Koh, Y. H., Kim, J., Koo, J. W., We, Y.-M., & Hoe, H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00192 · Cited by 9

Critical Review of the Alzheimer’s Disease Non-Transgenic Models: Can They Contribute to Disease Treatment?

Flores-Cuadra, J. A., Madrid, A., Fernández, P. L., Perez-Lao, A. R., Oviedo, D. C., Britton, G. B., & Carreira, M. B. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200870 · Cited by 9

The effects of GPER on age-associated memory impairment induced by decreased estrogen levels

Luo, W., Yan, Y., Cao, Y., Zhang, Y., & Zhang, Z. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1097018 · Cited by 8

Quo vadis PGRMC? Grand-Scale Biology in Human Health and Disease

Cahill, M. A. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2711318 · Cited by 8

Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease

Zhang, Y., & Lu, K. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2002055 · Cited by 8

Axonal transport deficits in neuropsychiatric disorders

Badal, K. K., & Puthanveettil, S. V. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2022.103786 · Cited by 7

Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice

Ma, R., Zhang, Y., Li, H., Kang, H. R., Kim, Y., & Han, K. (2023) · Animal Cells and Systems · doi:10.1080/19768354.2023.2192263 · Cited by 7

Advanced Immunolabeling Method for Optical Volumetric Imaging Reveals Dystrophic Neurites of Dopaminergic Neurons in Alzheimer’s Disease Mouse Brain

Baek, S., Jang, J., Jung, H. J., Lee, H., & Choe, Y. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03823-9 · Cited by 7

Biological effects of rapid short pulses of focused ultrasound for drug delivery to the brain

Morse, S. V., Rimer, S., Geoghegan, G., Shah, M. D., Chan, N., Yalcin, C., Pereira, M. A., Rohfleisch, L., Nkontchou, N., Winiarski, S., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113646 · Cited by 7

Adult mice with noise-induced hearing loss exhibited temporal ordering memory deficits accompanied by microglia-associated neuroplastic changes in the medial prefrontal cortex

Li, Q., Kang, X., Liu, L., Xiao, Y. M., Xu, D., Zhuang, H., Liu, H., Zhao, J., Zou, H., Yang, J., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106181 · Cited by 7

Amyloid Pathology Impairs Experience-Dependent Inhibitory Synaptic Plasticity

Niraula, S., Yan, S. S., & Subramanian, J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0702-23.2023 · Cited by 6

The NMDAR/TRPM4 death complex is a major promoter of disease progression in the 5xFAD mouse model of Alzheimer’s disease

Yan, J., Yang, X., Li, G., Ramírez, O. A., Hagenston, A. M., Chen, Z.-Y., & Bading, H. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03143-5 · Cited by 6

Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease

Tortolani, D., Decandia, D., Giacovazzo, G., Scipioni, L., Panuccio, A., Ciaramellano, F., Eugelio, F., Fanti, F., Latagliata, E. C., Barbera, L. L., et al. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1571428 · Cited by 6

Integrating analysis of mRNA expression profiles indicates Sgk1 as a key mediator in muscle-brain crosstalk during resistance exercise

Liu, Y., Ye, Q., Dai, Y., Hu, J., chen, J., Dong, J., Li, H., & Dou, Z. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150075 · Cited by 6

Restoring synaptic function through multimodal therapeutics

Loera‐Valencia, R., Ismail, M.-A.-M., Nilsson, P., & Winblad, B. G. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.07.003 · Cited by 6

Nanostructured Modulators of Neuroglia

Maysinger, D., & Ji, J. X. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190912163339 · Cited by 6

High-fat diet impairs the dendritic morphology of hippocampal CA1 pyramidal neurons in male but not female mice

Teng, S.-F., Lee, M. T., Lee, L., Hwang, L.-L., Chen, C.-P., Lee, H., Chen, C., & Chiou, L. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1687060 · Cited by 5

Ubiquitin ligase RFWD2 promotes dendritic spine and synapse formation by activating the ERK/PEA3/c-Jun pathway in rat cerebral cortical neurons

Zhong, G., Fang, Z., Sun, T., Ying, M., Wang, A., Chen, Y., Wang, H., Ma, C., Wang, C., Ge, R., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167319 · Cited by 5

Gene co-expression patterns shared between chemobrain and neurodegenerative disease models in rodents

Zare, M.-S., Abedpoor, N., Hajibabaie, F., & Walker, A. K. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106944 · Cited by 6

Microglia interact with dendritic spines and regulate spine numbers after brain injury following resuscitation from a cardiac arrest

Basak, J. M., Falk, M., Dingman, A., Moore, A., Tiemeier, E., Aimale, G., & Quillinan, N. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115364 · Cited by 6

O-GlcNAcase promotes dendritic spine morphogenesis while downregulating their GluA2-containing AMPA receptors

Han, L., Galizia, S., Pan, J., Bhattacharjee, M., & Lagerlöf, O. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111157 · Cited by 5

Establishment of a novel cellular model for Alzheimer's disease in vitro studies

El-Araby, R. E., Wasif, K., Johnson, R., Tu, Q., Aboushousha, T., Zhu, Z. X., & Chen, J. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114820 · Cited by 5

Colistin treatment causes neuronal loss and cognitive impairment via ros accumulation and neuronal plasticity alterations

Guzman, L., Parcerisas, A., Cano, A. C., Sánchez‐López, E., Verdaguer, E., Auladell, C., Cajal, Y., Barenys, M., Camins, A., Rabanal, F., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117839 · Cited by 6

Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease

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