The lysosomal function of progranulin, a guardian against neurodegeneration

Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria

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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

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A Gene Network Regulating Lysosomal Biogenesis and Function

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Cruts, M., Gijselinck, I., van der Zee, J., Engelborghs, S., Wils, H., Pirici, D., Rademakers, R., Vandenberghe, R., Dermaut, B., Martin, J.-J., et al. (2006) · Nature · doi:10.1038/nature05017 · Cited by 1,512

The prevalence of frontotemporal dementia

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Sortilin is essential for proNGF-induced neuronal cell death

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The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

Tang, W., Lu, Y., Tian, Q.-Y., Zhang, Y., Guo, F.-J., Liu, G.-Y., Syed, N. M., Lai, Y., Lin, E. A., Kong, L., et al. (2011) · Science · doi:10.1126/science.1199214 · Cited by 761

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., Shang, Y., Oldham, M. C., Martens, L. H., Gao, F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.001 · Cited by 729

Prosaposin: A Multifaceted Protein Orchestrating Biological Processes and Diseases

Li, X., & Guo, L. (2025) · Cells · doi:10.3390/cells14151131 · Cited by 13

Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis

Santos, M. N., Paushter, D. H., Zhang, T., Wu, X., Feng, T., Lou, J., Du, H., Becker, S. M., Fragoza, R., Yu, H., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102348 · Cited by 12

The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases

Takahashi, H., & Strittmatter, S. M. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00873-6 · Cited by 14

Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics

Petkau, T. L., Life, B. E., Lu, G., Yang, J., Fornés, O., Wasserman, W. W., Simpson, E. M., & Leavitt, B. R. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105314 · Cited by 13

Parkin beyond Parkinson’s Disease—A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies

Gawęda-Walerych, K., Sitek, E. J., Narożańska, E., & Buratti, E. (2021) · Cells · doi:10.3390/cells10123389 · Cited by 13

Plasma lysosphingolipids in GRN-related diseases: Monitoring lysosomal dysfunction to track disease progression

Khrouf, W., Saracino, D., Rucheton, B., Houot, M., Clot, F., Rinaldi, D., Vítor, J., Huynh, M., Heng, E., Schlemmer, D., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106108 · Cited by 11

Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.

Doyle, J. J., Maios, C., Vrancx, C., Duhaime, S., Chitramuthu, B. P., Bennett, H. P. J., Bateman, A., & Parker, J. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022115118 · Cited by 13

Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease

Sandhoff, R., & Sandhoff, K. (2022) · Advances in neurobiology · doi:10.1007/978-3-031-12390-0_12 · Cited by 12

GRN is a prognostic biomarker and correlated with immune infiltration in glioma: A study based on TCGA data

Xu, S., Xiao, H., Hu, Z.-X., Zhong, X., Zeng, Y., Wu, Y.-X., Li, D., & Song, T. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1162983 · Cited by 11

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b−/−Grn−/− mice

Feng, T., Minevich, G., Liu, P., Qin, H. X., Wozniak, G. G., Pham, J., Pham, K., Korgaonkar, A. A., Kurnellas, M., Defranoux, N. A., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107247 · Cited by 12

Innate Anti-microbial and Anti-chemotaxis Properties of Progranulin in an Acute Otitis Media Mouse Model

Wang, Z., He, Q., Zhang, X., Ma, Y., Fan, F., Dong, Y., Xu, W., Yin, Y., & He, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02952 · Cited by 11

Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress

Dedert, C., Mishra, V., Aggarwal, G., Nguyen, A. D., & Xu, F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.874258 · Cited by 13

Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal DementiaPreprint

Hsiao‐Nakamoto, J., Chiu, C., VandeVrede, L. A., Ravi, R., Vandenberg, B., Groot, J. D., Tsogtbaatar, B., Fang, M., Auger, P., Gould, N. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.09.579529 · Cited by 12

Analytical and clinical validation of a blood progranulin ELISA in frontotemporal dementias

Meda, F. J., Simrén, J., Borroni, B., Cantoni, V., Archetti, S., Biasiotto, G., Andréasson, U., Blennow, K., Kvartsberg, H., & Zetterberg, H. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-0562 · Cited by 9

First-In-Human Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of AZP2006, A Synthetic Compound for the Treatment of Alzheimer’s Disease and Related Diseases

Verwaerde, P., Estrella, C., Burlet, S., Barrier, M., Marotte, A.-A., & Clincke, G. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-220883 · Cited by 10

Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies

Salzano, S., Bertasini, C., Haghighi, S. T., Lundkvist, J., Wahlberg, L. U., Chiamulera, C., Vattemi, G. N. A., Gardoni, F., & Paolone, G. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107957 · Cited by 15

Neuroinflammation modulates the association of PGRN with cerebral amyloid-β burden

Xu, W., Tan, C., Cao, X., & Tan, L. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.02.016 · Cited by 11

Converging links between adult-onset neurodegenerative Alzheimer’s disease and early life neurodegenerative neuronal ceroid lipofuscinosis?

Hermey, G., & Klein, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.361544 · Cited by 10

sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models

Yang, C., Du, H., Lee, G. B., Uematsu, M., He, W., Doré, É., Yu, W., Sanford, E. J., Smolka, M. B., Boilard, É., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00863-8 · Cited by 10

Rethinking lysosomes and lysosomal disease

Walkley, S. U. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136155 · Cited by 10

The Role of White Matter Dysfunction and Leukoencephalopathy/Leukodystrophy Genes in the Aetiology of Frontotemporal Dementias: Implications for Novel Approaches to Therapeutics

Lok, H. C., & Kwok, J. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052541 · Cited by 10

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Tesla, R., Guhl, C., Werthmann, G. C., Dixon, D., Cenik, B., Addepalli, Y., Liang, J., Fass, D. M., Rosenthal, Z., Haggarty, S. J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50076-8 · Cited by 9

FTD-associated behavioural and transcriptomic abnormalities in ‘humanized’ progranulin-deficient mice: A novel model for progranulin-associated FTD

Life, B. E., Petkau, T. L., Cruz, G. N. F., Navarro‐Delgado, E. I., Shen, N., Korthauer, K. D., & Leavitt, B. R. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106138 · Cited by 9

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient NeuronsPreprint

Hasan, S., Fernandopulle, M. S., Humble, S. W., Frankenfield, A. M., Li, H., Prestil, R., Johnson, K. R., Ryan, B. J., Wade‐Martins, R., Ward, M. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529955 · Cited by 9

Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations

Pawlak, A., Stefanowicz, J., Kotkowska, Z., Gabryelska, A., Sochal, M., Napieraj, F., Kotlicka‐Antczak, M., & Strzelecki, D. (2025) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2025.1656232 · Cited by 9

Multiple Molecular Pathways Are Influenced by Progranulin in a Neuronal Cell Model–A Parallel Omics Approach

Chitramuthu, B. P., Campos‐García, V. R., & Bateman, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.775391 · Cited by 8

Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development

Boxy, P., Nykjær, A., & Kisiswa, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1181397 · Cited by 7

Integrated multi-omics analysis reveals common and distinct dysregulated pathways for genetic subtypes of Frontotemporal DementiaPreprint

Menden, K., Francescatto, M., Nyima, T., Blauwendraat, C., Dhingra, A., Castillo-Lizardo, M., Fernandes, N., Kaurani, L., Kronenberg‐Versteeg, D., Atasu, B., et al. (2021) · doi:10.21203/rs.3.rs-153135/v1 · Cited by 8

Copper toxicity of inflection point in human intestinal cell line Caco-2 dissected: influence of temporal expression patterns

Keenan, J., Meleady, P., O’Doherty, C., Henry, M. A., CLYNES, M. M., Horgan, K. A., Murphy, R. A., & O’Sullivan, F. (2021) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-020-00540-8 · Cited by 7

Single-cell multimodal analysis in a case with reduced penetrance of Progranulin-Frontotemporal Dementia

Natarajan, K., Eisfeldt, J., Hammond, M., Patra, K., Laffita‐Mesa, J. M., Andrade‐Talavera, Y., Birtele, M., Öijerstedt, L., Fisahn, A., Parmar, M., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01234-2 · Cited by 7

Microglial progranulin differently regulates hypothalamic lysosomal function in lean and obese conditions via cleavage-dependent mechanisms

Park, C. B., Lee, C. H., Kang, G. M., Min, S. H., & Kim, M. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03370-1 · Cited by 6

Progranulin and EGFR modulate receptor-like tyrosine kinase sorting and stability in mesothelioma cells

Ventura, E., Belfiore, A., Iozzo, R. V., Giordano, A., & Morrione, A. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00248.2023 · Cited by 6

Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease

Lin, Y., Zhao, X., Liou, B., Fannin, V., Zhang, W., Setchell, K. D. R., Wang, X., Pan, D., Grabowski, G. A., Liu, C.-J., et al. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae113 · Cited by 6

Sortilin is associated with progranulin deficiency and autism‐like behaviors in valproic acid‐induced autism rats

Liao, A., Zheng, W., Wang, S., Wang, N., Li, Y., Chen, D., & Wang, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70015 · Cited by 7

Ocular Manifestations of Neuronal Ceroid Lipofuscinoses

Singh, R. B., Gupta, P., Kartik, A., Farooqui, N., Singhal, S., Shergill, S., Singh, K. P., & Agarwal, A. K. (2021) · Seminars in Ophthalmology · doi:10.1080/08820538.2021.1936571 · Cited by 6

Lysosomal Storage Disorders

Sun, A., Chang, I. J., Lam, C. T., & Berry, G. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-812535-9.00014-5 · Cited by 7

Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning

Tran, M. L., Tüshaus, J., Kim, Y., Ramazanov, B. R., Devireddy, S., Lichtenthaler, S. F., Ferguson, S. M., & von Blume, J. (2022) · Traffic · doi:10.1111/tra.12873 · Cited by 6

Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

Tejwani, L., Heffner, C. M., Balak, C. D., Skuja, L. L., Tatarakis, D., Rana, A., Yu, S. B., Fitzgerald, G. A., Ha, C., de Melo, G. L., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.009 · Cited by 8

Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection

Kusakari, S., Suzuki, H., Nawa, M., Sudo, K., Yamazaki, R., Miyagi, T., Ohara, T., Matsuoka, M., & Kanekura, K. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106895 · Cited by 5

Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome

Life, B. E., Bettio, L. E. B., Gantois, I., Christie, B. R., & Leavitt, B. R. (2023) · Current Research in Neurobiology · doi:10.1016/j.crneur.2023.100094 · Cited by 4

Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia

Smith, D. M., Niehoff, M. L., Ling, K., Jafar‐Nejad, P., Rigo, F., Farr, S. A., Wilkinson, M., & Nguyen, A. D. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282822 · Cited by 5

Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degenerationPreprint

Robinson, S., Reich, M., Mühlhofer, M., Buschmann, K., Wauters, E., Mühlhofer, Q., Werner, G., Ahles, A., Engelhardt, S. H., Krenner, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.16.575687 · Cited by 5

Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementiaPreprint

Tan, L. X., Oertel, F. C., Cheng, A., Cobigo, Y., Keihani, A., Bennett, D. J., Abdelhak, A., Montes, S. C., Chapman, M. C., Chen, R. Y., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.595206 · Cited by 5

AZP2006 (Ezeprogind®): a Promising New Drug Candidate in the Battle Against Neurodegenerative Diseases

Verwaerde, P., & Defert, O. (2025) · ChemMedChem · doi:10.1002/cmdc.202400891 · Cited by 4

Astragalin-functionalized ultrasmall nanoparticles modulate the complement pathway to inhibit microglial synaptic phagocytosis for reducing anesthetic neurotoxicity

Wang, G., Han, Y., Peng, K., Jiang, Z., Wang, T., Zheng, Q., Li, W., Xu, H., Ji, F., & Li, Z. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101714 · Cited by 4

Retinal Degeneration and Microglial Dynamics in Mature Progranulin-Deficient Mice

Takahashi, K., Nakamura, S., Shimazawa, M., & Hara, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111557 · Cited by 4

Increased Fat Taste Preference in Progranulin-Deficient Mice

Schumann, L., Wilken‐Schmitz, A., Trautmann, S., Vogel, A., Schreiber, Y., Hahnefeld, L., Gurke, R., Geißlinger, G., & Tegeder, I. (2021) · Nutrients · doi:10.3390/nu13114125 · Cited by 4

Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice

Cook, A. K., Greathouse, K. M., Manuel, P. N., Cooper, N. H., Eberhardt, J. M., Freeman, C. D., Weber, A. J., Herskowitz, J. H., & Arrant, A. E. (2024) · Molecular Brain · doi:10.1186/s13041-024-01095-5 · Cited by 4

Comprehensive circular RNA profiling in various sheep tissues

Bakhtiarizade, M. R., Heidari, M., & Ghanatghestani, A. H. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-76940-7 · Cited by 3

Evaluating sample normalization methods for MS-based multi-omics and the application to a neurodegenerative mouse model

Lee, G. B., Yang, C., Hu, F., & Hao, L. (2025) · The Analyst · doi:10.1039/d4an01573h · Cited by 4

The Transcriptomic Signature of Donkey Ovarian Tissue Revealed by Cross-Species Comparative Analysis at Single-Cell Resolution

Tian, Y., Niu, Y., Zhang, X., Wang, T., Tian, Z., Zhang, X., Guo, J., Ge, W., Liu, S., Sun, Y., et al. (2025) · Animals · doi:10.3390/ani15121761 · Cited by 4

Development of AL101 (GSK4527226), a progranulin-elevating monoclonal antibody, as a potential treatment for Alzheimer’s disease

Budda, B., Mitra, A., Park, L., Long, H., Kurnellas, M., Bien‐Ly, N., Estacio, W. F., Burgess, B., Chao, G., Schwabe, T., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01817-4 · Cited by 4

Serum progranulin as a predictive marker for high activity of antineutrophil cytoplasmic antibody‐associated vasculitis

Yoon, T., Lee, L. E., Ahn, S. S., Pyo, J. Y., Song, J. J., Park, Y., & Lee, S. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24048 · Cited by 4

Parkinsonism in complex neurogenetic disorders: lessons from hereditary dementias, adult-onset ataxias and spastic paraplegias

Aloisio, S., Satolli, S., Bellini, G., & Lopriore, P. (2023) · Neurological Sciences · doi:10.1007/s10072-023-07044-9 · Cited by 4

Insights into Autophagic Machinery and Lysosomal Function in Cells Involved in the Psoriatic Immune-Mediated Inflammatory Cascade

Kuczyńska, M., Moskot, M., & Gabig‐Cimińska, M. (2024) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.2478/aite-2024-0005 · Cited by 4

Multi-tissue proteomics identifies molecular signatures for sporadic and genetically defined Alzheimer disease casesPreprint

Cruchaga, C., Sung, Y. J., Yang, C., Wang, F., Suhy, A., Norton, J. B., Novotny, B. C., Eteleeb, A. M., Fagan, A. M., Bateman, R. J., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-923492/v1 · Cited by 4

Lysosomes cell autonomously regulate myeloid cell states and immune responses

Tejwani, L., Balak, C., Skuja, L. L., Tatarakis, D., Rana, A., Fitzgerald, G. A., Ha, C., Lunkes de Melo, G., Sun, E. W., Heffner, C. M., et al. (2024) · doi:10.1101/2024.11.11.623074 · Cited by 4

Targeting Granulin Haploinsufficiency in Frontotemporal Dementia: From Genetic Mechanisms to Therapeutics

Bagyinszky, E., & An, S. S. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209960 · Cited by 3

Non-canonical roles of lysosomes in neurons

Spencer, J. I., Sudarikova, Y., & Devine, M. J. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.10.009 · Cited by 4

Adipose-derived stem cell transplantation enhances spinal cord regeneration by upregulating PGRN expression

Zhang, Q., Wu, J., Guo, D. S., Ji, N., Liu, W., Li, X., Liu, H., Zhang, C., Zhao, M.-C., Li, H., et al. (2024) · Neuroreport · doi:10.1097/wnr.0000000000002091 · Cited by 3

Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium

Takahashi, K., Nakamura, S., Shimazawa, M., & Hara, H. (2022) · In Vivo · doi:10.21873/invivo.12744 · Cited by 4

Antiviral effect of lysosomotropic disaccharide trehalose on porcine hemagglutinating encephalomyelitis virus, a highly neurotropic betacoronavirus

Ai, X., He, W., Wang, X., Wang, Z., Wang, G., Lu, H., Qin, S., Li, Z., Guan, J., Zhao, K., et al. (2022) · Virology · doi:10.1016/j.virol.2022.10.013 · Cited by 3

SorCS2 binds progranulin and regulates motor axon outgrowthPreprint

Thomasen, P. B., Salašová, A., Login, H., Beel, S., Tranberg-Jensen, J., Qvist, P., Ovesen, P. L., Nolte, S., Nejsum, L. N., Chao, M. V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.08.527602 · Cited by 3

Lysosomal enzyme processing and trafficking in the social amoeba Dictyostelium discoideum

Condie, S. V., Kim, W. D., & Huber, R. J. (2025) · Biochemistry and Cell Biology · doi:10.1139/bcb-2025-0062 · Cited by 2

DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal Lobar degeneration genetic risk-associated loci

Rambarack, N., Fodder, K., Murthy, M. N., Toomey, C. E., de Silva, R., Heutink, P., Humphrey, J., Raj, T., Lashley, T., & Bettencourt, C. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02071-3 · Cited by 3

Hippocampal neuronal progranulin mediates estrogen‑deficiency‑induced affective vulnerability and lysosomal-autophagic dysfunction

Lin, N., Chen, T.-H., Jia, S.-Q., Yang, Q., Yang, A., Liu, Y.-Z., Wu, T., Xu, Y.-N., Liu, T.-T., Hu, Z., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03790-2 · Cited by 2

Association of Progranulin Gene Expression from Dyspeptic Patients with Virulent Helicobacter pylori Strains; In Vivo Model

Troncoso, C., Pávez, M., Cerda, Á., Manríquez, V., Prado, A., Hofmann, E., Ríos, E., Sierralta, A., Copelli, L., & Barrientos, L. (2022) · Microorganisms · doi:10.3390/microorganisms10050998 · Cited by 3

Cross‐species signaling pathways analysis inspire animal model selections for drug screening and target prediction in vascular aging diseases

Sun, F., Chen, X., Zhang, S., Jiang, H., Chen, T., Xing, T., Li, X., Sultan, R., Wang, Z., & Jia, J. (2024) · Evolutionary Applications · doi:10.1111/eva.13708 · Cited by 2

Sleep Characteristics and Cerebrospinal Fluid Progranulin in Older Adults: The CABLE Study

Wang, M., Sun, F.-R., Bi, Y., Ma, Y., Yin, J., Shen, X., Wang, X., Tan, L., & Yu, J. (2021) · Neurotoxicity Research · doi:10.1007/s12640-020-00326-6 · Cited by 2

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathologyPreprint

Reifschneider, A., Robinson, S., van Lengerich, B., Gnörich, J. S., Logan, T., Heindl, S., Vogt, M. A., Weidinger, E., Riedl, L., Wind-Mark, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.08.451574 · Cited by 2

Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulinPreprint

Reich, M., Simon, M. J., Polke, B., Werner, G., Schrader, C. M., Paris, I., Robinson, S., Davis, S. S., de Melo, G. L., Schlaphoff, L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.14.549089 · Cited by 2

Unraveling the intercellular communication disruption and key pathways in Alzheimer's disease: An integrative study of single-nucleus transcriptomes and genetic associationPreprint

Liu, A., Fernandes, B. S., Citu, C., & Zhao, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-3335643/v1 · Cited by 2

LRP10 promotes trafficking of progranulin and prosaposin to lysosomesPreprint

Filippini, F., Devireddy, S., & Ferguson, S. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.02.651888 · Cited by 2

Lysosomal Multi-Omics Reveals Altered Sphingolipid Catabolism As Driver of Lysosomal Dysfunction in the Aging BrainPreprint

Sarkar, C., Chen, Y., Nguyen, D. P., Weldemariam, M. M., Morel, Y., Mehrabani-Tabari, A. A., Gorny, N., Pettyjohn-Robin, O., Hegdekar, N., Thapa, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.10.675421 · Cited by 2

Extracellular chaperones in lysosomal storage diseases

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Progranulin deficiency does not exacerbate TDP-43 pathology in TDP-43 transgenic mouse models

Yang, C., Feng, T., & Hu, F. (2025) · npj Dementia · doi:10.1038/s44400-025-00020-4 · Cited by 1

Proteome-wide association study identifies novel Alzheimer's disease-associated proteins

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Genetic evidence supports therapeutic modulation of progranulin levels in Alzheimer’s Disease

Robins, C., Eicher, J. D., Liu, J., Lo, Y., Richardson, T. G., Western, D., Davitte, J., Cruchaga, C., Initiative, A. D. N., Kumar, U., et al. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-025-00011-y · Cited by 1

Tissue-specific immune and MAPK signatures in models of reduced Progranulin and Western diet

Merchak, A. R., Rodrigues, M. E. D. S., Cole, C. L., Neighbarger, N. K., Bhavsar, N., Wallings, R. L., Joers, V. L., Chang, J., Kelly, S. D., Sampson, T. R., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107287 · Cited by 1

FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis

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The role of Grn in the development of mouse cochlear nucleus synapses

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Animal granulins: In the GRN scheme of things

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Developing a scoring system for gene curation prioritization in lysosomal diseases

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Honokiol rescues progranulin deficiency in pathogen-induced and genetically driven neurodegeneration: Bridging veterinary models with therapeutic development

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Fluid and Imaging Markers of Frontotemporal Lobar Degeneration

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Reduced progranulin increases tau and α -synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidasePreprint

Takahashi, H., Bhagwagar, S. Z., Nies, S. H., Chiasseu, M., Wang, G., Mackenzie, I. R., & Strittmatter, S. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.25.521308 · Cited by 1

DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated lociPreprint

Rambarack, N., Fodder, K., Murthy, M. N., Toomey, C. E., de Silva, R., Heutink, P., Humphrey, J., Raj, T., Lashley, T., & Bettencourt, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.21.634065 · Cited by 1

Pgrn Alleviates Cerebral Amyloid-β Burden and Cognitive Impairments via Mediating NeuroinflammationPreprint

Xu, W., Tan, C., Cao, X., Yu, J., & Tan, L. (2020) · doi:10.21203/rs.3.rs-32425/v1

IPSC-derived GRN-mutant astrocytes delay excitatory electrical development of neurons in a non-cell autonomous manner

Lee, C. (2021) · cIRcle (University of British Columbia) · doi:10.14288/1.0400595

New alkylating agents: butyrophenone derivatives.

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Upregulation of Trem2 expression occurs exclusively on microglial contact with plaquesPreprint

Wood, J. I., Wong, E., Joghee, R., Balbaa, A., Vitanova, K. S., VanSchoiack, A., Phelan, S.-L. J., Launchbury, F., Desai, S., Tripathi, T., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.26.477873

PGRN alleviates cerebral amyloid-β burden and cognitive impairments via mediating neuroinflammationPreprint

Xu, W., Tan, C., Cao, X., Yu, J., & Tan, L. (2020) · doi:10.21203/rs.3.rs-44700/v1

PGRN Alleviates Cerebral Amyloid-β Burden and Cognitive Impairments via Mediating NeuroinflammationPreprint

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Correcting the Aberrant Progranulin-Deficient Lysosomal Proteome via HDAC InhibitionPreprint

Werthmann, G. C., Tesla, R., Wong, C. H. Y., Haggarty, S. J., & Herz, J. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4160142

Progranulin in diagnosis of early onset neonatal sepsis. Is it reliable?

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Lipid Dysregulation Unveil the Intricate Interplay of Lysosomal and Mitochondrial Changes in Frontotemporal Dementia with GRN HaploinsufficiencyPreprint

Ondaro, J., Zúñiga-Elizari, J. L., Zufiría, M., Garciandia-Arcelus, M., Zulaica, M., Lafarga, M., Riancho, J., Holt, I. J., de Munaín, A. L., Moreno, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.22.576606

HIF-1α is Required to Differentiate the Neonatal Macrophage Secretome from AdultsPreprint

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Degenerazioni lobari frontotemporali: neuropatologia, genetica e classificazione

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Progranulin preserves mitochondrial health and turnover in neurons under hyperglycemic stress in a p97-dependent mannerPreprint

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Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia

Simon, M. J., Logan, T., DeVos, S. L., & Di Paolo, G. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.09.006 · Cited by 94

Progranulin Regulations of Lysosomal Homeostasis and Its Involvement in Neurodegenerative Diseases

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Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology

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Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused byGRNMutations

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Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

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