The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
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A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling.
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The protein encoded by SPPL2A is involved in noncanonical shedding of TNF-α, and PGRN has been described as a TNF receptor ligand and an antagonist of TNF-α signaling.
“The protein encoded by SPPL2A is involved in noncanonical shedding of TNF-α34, and PGRN has been described as a TNF receptor ligand and an antagonist of TNF-α signaling35.”
From New insights into the genetic etiology of Alzheimer’s disease and related dementias (2022) · cites this paper as [35]
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- Authors
- Tang, W., Lu, Y., Tian, Q.-Y., Zhang, Y., Guo, F.-J., Liu, G.-Y., Syed, N. M., Lai, Y., Lin, E. A., Kong, L., Su, J., Yin, F., Ding, A.-H., Zanin-Zhorov, A., Dustin, M. L., Tao, J., Craft, J., Yin, Z., Feng, J. Q., Abramson, S. B., Yu, X.-P., & Liu, C.-J.
- Affiliations
- Shandong University (CN)
- Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.
- New York University Langone Orthopedic Hospital (US)
- Cytovance Biologics, Oklahoma City, OK 73104, USA.
- Cornell University (US)
- Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
- Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
- NYU Langone Health (US)
- Yale University (US)
- Nankai University (CN)
- Texas A&M Health Science Center (US)
- Institute of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong 250012, China.
- Corresponding author
- Tang, Wei
- Lu, Yi
- Liu, Chuan-ju
- ORCID
- Venue
- Science
- Published
- 2011-04-22
- Volume
- 332
- Issue
- 6028
- Pages
- 478-484
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3104397
- OpenAlex
- W2068681851
- Cited by
- 761
- References
- 35
- Citations by year
- 2026: 31 · 2025: 30 · 2024: 69 · 2023: 48 · 2022: 52 · 2021: 51 · 2020: 42 · 2019: 58 · 2018: 58 · 2017: 45 · 2016: 59 · 2015: 53 · 2014: 48 · 2013: 41 · 2012: 53
- FWCI
- 38.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AR050620, AR053210, GM061710, AI43542, AR040072)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- progranulin, TNF receptor, TNF signaling, inflammatory arthritis, collagen-induced arthritis, rheumatoid arthritis, receptor ligands, anti-inflammatory therapy, TNF-alpha antagonism
- MeSH terms
- Progranulins, Granulins, Adolescent, Adult, Aged, Animals, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Experimental, Cartilage, Articular, Female, Humans, Ligands, Male, Mice, Inbred Strains, Mice, Transgenic, Middle Aged, Recombinant Fusion Proteins, Recombinant Proteins, Tumor Necrosis Factor-alpha, Signal Transduction, Mice, Knockout, Intercellular Signaling Peptides and Proteins, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, T-Lymphocytes, Regulatory, Mice, Protein Interaction Domains and Motifs, Young Adult
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