Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

Hsu, S. M., Raine, L., & Fanger, H. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.4.6166661 · Cited by 14,075

The molecular pathology of Alzheimer's disease

Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708

Amyloid, the presenilins and Alzheimer’s disease

Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107

The Pathogenesis of Senile Plaques

DICKSON, D. W. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199704000-00001 · Cited by 753

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

Selkoe, D. J. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.002105 · Cited by 748

Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

Griffin, W. S. T., Sheng, J. G., Royston, M. C., Gentleman, S., McKenzie, J. E., Graham, D. I., Roberts, G. W., & Mrak, R. E. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00136.x · Cited by 712

Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections

Braak, H., & Braak, E. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00661.x · Cited by 598

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546

Molecular Imaging of Neuroinflammation in Alzheimer’s Disease and Mild Cognitive Impairment

Kim, J., & Kim, Y. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_14 · Cited by 3

The many connections of UFMylation with Alzheimer’s disease: a comprehensive review

Yan, T., Clarkson, B. D. S., Lou, Z., Springer, W., & Fiesel, F. C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00855-8 · Cited by 4

The Fault in Our Astrocytes - cause or casualties of proteinopathies of ALS/FTD and other neurodegenerative diseases?

Bustos, L. M., & Sattler, R. (2023) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2023.1075805 · Cited by 4

Human induced pluripotent stem cell– based modeling of Alzheimer’s disease, a glial perspective

Chen, X., Yang, Q., Liu, Z., & Shi, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85764-2.00006-5 · Cited by 4

Apolipoprotein E (APOE) Isoforms and Neurobiology of Sporadic Alzheimer’s Disease

Mollica, A., Berardino, G., Bellomo, A., Altamura, M., Panza, F., & Lozupone, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_155-1 · Cited by 2

PET and the Multitracer Concept: An Approach to Neuroimaging Pathology

Engler, H. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 2

Astrocytic Activation Completely Corrects Memory Performance in an Alzheimer’s Disease ModelPreprint

Kreisel, T., Weinstein, Y., Groysman, M., Doron, A., Refaeli, R., London, M., & Goshen, I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.29.679133 · Cited by 2

Selective Inhibition of Tumor Necrosis Factor for Attenuating Alzheimer’s Disease: Strategies Targeting Neuroinflammation

Udaiyappan, J. P., Balakrishnan, R., Tamilarasan, M. M., Balasubramanian, B., & Abass, K. S. (2026) · Inflammation · doi:10.1007/s10753-026-02492-9 · Cited by 3

Role of Reactive Astrocytes in Alzheimer’s Disease

Sarkar, S., Guha, S., & Biswas, S. C. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_9 · Cited by 1

Protective Effects of Cannabis in Neuroinflammation-Mediated Alzheimer's Disease

Kashif, M., Waseem, M., Vijendra, P. D., & Pandurangan, A. K. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5652-1.ch002 · Cited by 2

Human iPSC-derived Astrocytes Transplanted into the Mouse Brain Display three Morphological Responses to Amyloid-β PlaquesPreprint

Preman, P., Julia, T. C. W., Calafate, S., Snellinx, A., Alfonso-Triguero, M., Corthout, N., Munck, S., Thal, D. R., Goate, A., Strooper, B. D., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-112937/v1 · Cited by 1

Glial Cells and Aβ Peptides in Alzheimer’s Disease Pathogenesis

Siu, G., Clifford, P., Kosciuk, M. C., Venkataraman, V., & Nagele, R. G. (2006) · Springer eBooks · doi:10.1007/978-1-84628-440-3_13

Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism

Basak, J. M. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7dz06bk

Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins

Nielsen, H. M. (2007) · Lund University Publications (Lund University)

Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

Yu, W. (2006) · Figshare

Alzheimer’s Disease Therapeutics Targeting Apolipoprotein E

Liao, F., & Holtzman, D. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00010-1

Phenotypic Pattern of Astrocyte Activation in Response to Aging and Alzheimer's-Like Pathology in Chimpanzees

Munger, E. L. (2016) · OhioLink ETD Center (Ohio Library and Information Network)

Enhancing CNS Repair in Neurological Disease Arising from Neurodegeneration and

Xu, X., Warrington, A. E., Bieber, A. J., & Rodriguez, M. (2011)

Activation of Astrocytes in Neurodegenerative Diseases

Li, J., & Qin, S. (2021) · Neuromethods · doi:10.1007/978-1-0716-1712-0_3

Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears

Bulck, M. V., Brandt, N., Claus, R. A., Gräler, M. H., & Bräuer, A. U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042300

BIBLIOGRAPHY

(2007) · Elsevier eBooks · doi:10.1016/b978-012373657-4/50008-8

Apolipoprotein E (APOE) Isoforms and Neurobiology of Sporadic Alzheimer’s Disease

Mollica, A., Berardino, G., Bellomo, A., Altamura, M., Panza, F., & Lozupone, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_155

Additional file 4 of Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, M., Beretta, C., Naia, L., Dakhel, A., Påvénius, L., Brismar, H., Lindskog, M., Ankarcrona, M., & Erlandsson, A. (2023) · Figshare · doi:10.6084/m9.figshare.22610219

Additional file 5 of Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, M., Beretta, C., Naia, L., Dakhel, A., Påvénius, L., Brismar, H., Lindskog, M., Ankarcrona, M., & Erlandsson, A. (2023) · Figshare · doi:10.6084/m9.figshare.22610222

Minimally invasive diagnosis of Alzheimer’s disease by detecting microRNA using a quartz crystal resonator

Swarbrick, S. (2019) · Loughborough University Research Repository (Loughborough University) · doi:10.26174/thesis.lboro.8272994

Additional file 8 of Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, M., Beretta, C., Naia, L., Dakhel, A., Påvénius, L., Brismar, H., Lindskog, M., Ankarcrona, M., & Erlandsson, A. (2023) · Figshare · doi:10.6084/m9.figshare.22610228

Additional file 2 of Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, M., Beretta, C., Naia, L., Dakhel, A., Påvénius, L., Brismar, H., Lindskog, M., Ankarcrona, M., & Erlandsson, A. (2023) · Figshare · doi:10.6084/m9.figshare.22610213

Additional file 1 of Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

Preman, P., Julia, T. C. W., Calafate, S., Snellinx, A., Alfonso-Triguero, M., Corthout, N., Munck, S., Thal, D. R., Goate, A., Strooper, B. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16681657

Additional file 1 of Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, M., Beretta, C., Naia, L., Dakhel, A., Påvénius, L., Brismar, H., Lindskog, M., Ankarcrona, M., & Erlandsson, A. (2023) · Figshare · doi:10.6084/m9.figshare.22610210

Additional file 3 of Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, M., Beretta, C., Naia, L., Dakhel, A., Påvénius, L., Brismar, H., Lindskog, M., Ankarcrona, M., & Erlandsson, A. (2023) · Figshare · doi:10.6084/m9.figshare.22610216

Additional file 7 of Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, M., Beretta, C., Naia, L., Dakhel, A., Påvénius, L., Brismar, H., Lindskog, M., Ankarcrona, M., & Erlandsson, A. (2023) · Figshare · doi:10.6084/m9.figshare.22610225

Implication des métabolites de l'APP dans les troubles mnésiques précoces chez la souris TgCRND8, un modèle de la maladie d'Alzheimer

Hamm, V. (2016) · theses.fr (ABES) · doi:10.70675/39443da7z44bfz4b29zbbbezb2b0dfba178a

Propagation axonale des pathologies Tau et Aβ dans la maladie d'Alzheimer : à la recherche de propagons dans le circuit subiculo-fornico-mamillaire

Thierry, M. (2020) · theses.fr (ABES) · doi:10.70675/d2f36d94zaa16z4617z94c6zabb1ad26f3fb

The Use of Localized Proteomics to Understand the Pathogenesis of Alzheimer's Disease

Pires, G. (2021) · theses.fr (ABES) · doi:10.70675/45826fd6zd2c8z4b3dz91e0za5080544cb17

Exploring the role of CHRFAM7A in the early stages of Alzheimer's disease : in vitro studies and development of a novel humanized mouse model

Pou, M. L. (2023) · theses.fr (ABES) · doi:10.70675/0424309azddeaz4545z8176z8df20cea5e8f

Entorhinal cortex astrocytes in early Alzheimer disease: Human evidence, cross-species circuit rationale, and translational boundaries

Wu, F., & Wang, M. (2026) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlag098

Regulation and Pharmacological Manipulation of the Type 5 Metabotropic Glutamate (mGlu5) Receptor

Bradley, S. J. (2011) · Leicester Research Archive (University of Leicester)

Fleecy Amyloid Deposits in the Internal Layers of the Human Entorhinal Cortex are Comprised of N-terminal Truncated Fragments of Aβ

Thal, D. R., Sassin, I., Schultz, C., Haass, C., Braak, E., & Braak, H. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199902000-00010 · Cited by 77

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

Cabrera, E., Mathews, P. M., Mezhericher, E., Beach, T. G., Deng, J., Neubert, T. A., Rostagno, A. A., & Ghiso, J. A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.005 · Cited by 78

Secretion and Intracellular Generation of Truncated Aβ in β-Site Amyloid-β Precursor Protein-cleaving Enzyme Expressing Human Neurons

Lee, E. B., Skovronsky, D., Abtahian, F., Doms, R. W., & Lee, V. M. ‐. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210105200 · Cited by 78

Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Beretta, C., Svensson, E., Dakhel, A., Zyśk, M., Hanrieder, J., Sehlin, D., Michno, W., & Erlandsson, A. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103916 · Cited by 12

Aminopeptidase A contributes to the N‐terminal truncation of amyloid β‐peptide

Sévalle, J., Amoyel, A., Robert, P. H., Fournié‐Zaluski, M., Roques, B. P., & Checler, F. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05950.x · Cited by 108