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Cited by 27

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

The effect of rapid preconditioning on the microglial, astrocytic and neuronal consequences of global cerebral ischemia

Pérez-Pinzón, M. A., Vitro, Teresa M., Dietrich, W. Dalton, Sick, Thomas J.·1999·Acta Neuropathologica
DOI 10.1007/s004010051019
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Abstract

Previous studies indicated preconditioning of the brain with sublethal ischemic insults separated by many hours, protected tissues from a subsequent lethal insult. We recently reported neuroprotection by a rapid preconditioning paradigm where a sublethal ischemic insult preceded test ischemia by only 30 min. We hypothesize that neuroprotection caused by the rapid ischemic preconditioning (IPC) will result in lowered microglial, reactive astrocytes and increased normal neuronal cell counts. Wistar rats underwent normothermic (36.5-37 degrees C) global cerebral ischemia, produced by bilateral carotid artery ligation after lowering mean systemic blood pressure. The preconditioning ischemic insult lasted 2 min and was associated with a sufficient amount of time to provoke anoxic depolarization. After a 30-min reperfusion period, 10-min test ischemia was produced, and histopathology was assessed 3 and 7 days later. Normal neuronal cell counts for control rats at 3 days survival were significantly lower (by 58%) than in IPC animals. Although there was a trend toward protection in IPC rats at 7 days, the difference in normal neuronal cell count between the IPC and control groups was not significant. IPC rats at 3 days but not 7 days of survival showed a significantly lower microglial cell count (by 56%) than control rats. These results showed that the protection induced through IPC at 3 days of survival produced lower numbers of microglia, while maintaining normal neuronal cells. No…

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Crossref · 10.1007/s004010051019

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24 of 24 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Pérez-Pinzón, M. A., Vitro, T. M., Dietrich, W. D., & Sick, T. J.
Venue
Acta Neuropathologica
Publisher
Springer Science and Business Media LLC
Published
1999-05-09
Volume
97
Issue
5
Pages
495-501
ISSN
  • 0001-6322
  • 1432-0533
DOI
10.1007/s004010051019
Cited by
27
References
24
Licence
www.springer.com/tdm (tdm)

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.