The content of free amino acids in the stratum corneum is increased in senile xerosis
Abstract
Xerosis is one of the characteristics of aged skin. Xerosis may be caused by a decrease in the stratum corneum free amino acids which are natural moisturizing factors derived from filaggrin. In aged skin, filaggrin is immunohistochemically decreased compared with the levels in young skin. However, the differences in stratum corneum amino acids between aged and young skin have not been analyzed quantitatively. Therefore, in this study we determined the stratum corneum amino acids per 1000 stratum corneum cells in aged and young skin by high-performance liquid chromatography. The amount of filaggrin mRNA in the epidermis was also compared between aged and young skin using RT-PCR. The total amount of amino acids in the stratum corneum was larger in aged senile xerosis skin than in young skin. Only a few amino acids were found in the stratum corneum of ichthyosis vulgaris patients (control skin). The expression of filaggrin mRNA in aged skin was, however, similar to that in young skin. These findings suggest that the immunohistochemical decrease in filaggrin in aged skin may be caused by promotion of filaggrin proteolysis in the upper layers of the stratum spinulosum.
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The age of the individual has been reported as a predisposing factor for C. auris skin colonization in some studies, with C. auris-colonized patients aged 65-80 years at greater risk.
“The age of the individual has been reported as a predisposing factor for C. auris skin colonization in some studies, with C. auris-colonized patients aged 65–80 years at greater risk [62–64].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [63]
The skin of older individuals shows reduced lipid content and natural moisturizing factors, which are essential for maintaining an effective stratum corneum barrier.
“The skin of older individuals also shows reduced lipid content and natural moisturizing factors, which are essential for maintaining an effective stratum corneum barrier [62,63].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [63]
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Skrylova, K. A., Khardikova, S. A., Dmitruk, V. S., & Klimenko, A. M. (2020) · Russian Journal of Clinical Dermatology and Venereology · doi:10.17116/klinderma202019041489
Ulrich, N. H., Thyssen, J. P., Mizutani, H., & Nixon, R. L. (2019) · Springer eBooks · doi:10.1007/978-3-319-72451-5_61-1
The Molecular Aspects of Dry, Flaky Skin Conditions
Laloeuf, A., & Byrne, A. J. (2009) · Basic and clinical dermatology · doi:10.3109/9781420070958.011
- Authors
- Takahashi, M., & Tezuka, T.
- Affiliations
- Kindai University (JP)
- Corresponding author
- Takahashi, Masae
- Venue
- Archives of Dermatological Research
- Published
- 2004-03-01
- Volume
- 295
- Issue
- 10
- Pages
- 448-452
- ISSN
- 0003-9187 (ISSN-L)
- 0340-3696
- 1432-069X
- OpenAlex
- W1982702386
- Cited by
- 79
- References
- 25
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 4
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Dermatological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- stratum corneum, free amino acids, natural moisturizing factor, filaggrin, skin aging, ichthyosis vulgaris, stratum spinosum
- MeSH terms
- Filaggrin Proteins, Adult, Aged, Aged, 80 and over, Amino Acids, Chromatography, High Pressure Liquid, Epidermis, Humans, Immunohistochemistry, Intermediate Filament Proteins, Middle Aged, RNA, Messenger, Skin Diseases, Skin Aging, Case-Control Studies, Ichthyosis Vulgaris, Reverse Transcriptase Polymerase Chain Reaction
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