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Cited by 91Reproductive tract infections researchUrinary Tract Infections ManagementGynecological conditions and treatments

Use of Locally Delivered Dequalinium Chloride in the Treatment of Vaginal Infections: A Review

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Mendling, Werner, Weissenbacher, Ernst Rainer, Gerber, Stefan, Prasauskas, Valdas, Grob, Philipp·2016·Archives of Gynecology and Obstetrics
DOI 10.1007/s00404-015-3914-8PMC PMC4757629
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Abstract

BACKGROUND: Vaginal infections are responsible for a large proportion of gynaecological outpatient visits. Those are bacterial vaginosis (BV), vulvovaginal candidosis (VVC), aerobic vaginitis (AV) associated with aerobic bacteria, and mixed infections. Usual treatments show similar acceptable short-term efficacy, but frequent recurrences and increasing microbial resistance are unsolved issues. Furthermore, vaginal infections are associated with a variety of serious adverse outcomes in pregnancy and generally have a major impact on quality of life. Identifying the correct therapy can be challenging for the clinician, particularly in mixed infections. FINDINGS: Dequalinium chloride (DQC) is an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity. Systemic absorption after vaginal application of DQC is very low and systemic effects negligible. Vaginal DQC (Fluomizin vaginal tablets) has been shown to have equal clinical efficacy as clindamycin in the treatment of BV. Its broad antimicrobial activity makes it appropriate for the treatment of mixed vaginal infections and in case of uncertain diagnosis. Moreover, resistance of pathogens is unlikely due to its multiple mode of action, and vaginal DQC provides also a reduced risk for post-treatment vaginal infections. CONCLUSIONS: Vaginal DQC (10 mg) as 6-day therapy offers a safe and effective option for empiric therapy of different vaginal infections in daily practice. This review summarizes the available and relevant pharmacological and clinical data for the therapy of vaginal infections with vaginal DQC and provides the rationale for its use in daily gynaecologic practice.

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  • The findings of Mendling and colleagues on dequalinium chloride effectiveness in pregnant VVC cannot be considered certainly relevant.

    “That is why their findings can not be considered as certainly relevant [72].”

    From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [72]

  • The conclusions by Mendling and colleagues that dequalinium chloride is effective for VVC in pregnant patients were based on an unpublished drug utilization trial and a study with a small sample size.

    “Mendling and colleagues have indicated this agent as an effective treatment option leading to the cure of VVC in pregnant patients; however, their conclusions were drawn based on the results of an unpublished drug utilization trial, as well as a study with a small sample size.”

    From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [72]

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  1. [45]Recurrent Hay P Vaginosis Bacterial Curr Infect Dis Rep 2000 2 6 506 512 11095900
  2. [64]Marghescu S Zur Behandlung bakterieller und mykotischer Hautinfektionen in den intertriginösen Räumen Ther d Gegenw 1975 114 3 427 434 1121676
  3. [67]D’Auria FD Simonetti G Strippoli V Caratteristiche antimicrobiche di una tintura al dequalinio cloruro Ann Ig 1989 1 1227 1241 2483904
  4. [68]Brauss FW Rieth H Wirksamkeit von Dekamethylenaminochinaldiniumchlorid gegenüber pathogenen Mikroorganismen Münch Med Wschr 1974 35 1519 1520 4213804
  5. [88]Atlante G Un nuovo chemioterapico nella terapia delle vaginiti da trichomonas e da candida Minerva Ginecol 1959 11 588 591 13794982
  6. [89]Bianco V, Minorchio E, Biraghi P, Stillo A, Como ML (1984) Impiego di una associazione di dequalinium, tirotricina e idrocortisone in lavanda nella terapia delle cervico vaginiti: studio clinico controllato. Ann Ost Gin Med Perin CV (4):260–266 6393838
  7. [90]Crevoisier P Serment H Habersaat A Behandlung des Fluor vaginalis mit dem polyvalenten Kombinationspräparat Trichocid Praxis 1970 40 1401 1404 5512717
  8. [92]Kolbe H Zur Behandlung des infektiösen vaginalen Fluors mit Dequavagyn Ther d Gegenw 1972 111 3 415 420 5024594
  9. [93]Kucera H Kupka S Zur Behandlung des infektiösen Fluors durch Dequaliniumchlorid und seiner Kombination mit verschiedenen Östriolkomponenten Wien Med Wochenschr 1973 123 46 683 685 4753092
  10. [100]Tatra G Behandlung des infektiösen Fluors mit Dequavagyn Münch Med Wschr 1972 114 16 773 776 5067887

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Authors
Mendling, W., Weissenbacher, E. R., Gerber, S., Prasauskas, V., & Grob, P.
Corresponding author
Mendling, Werner
ORCID
Mendling, Werner
Venue
Archives of Gynecology and Obstetrics
Publisher
Springer Science and Business Media LLC
Published
2015-10-27
Volume
293
Issue
3
Pages
469-484
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
DOI
10.1007/s00404-015-3914-8
PMC
PMC4757629
OpenAlex
W2221309063
Cited by
91
References
99
Citations by year
2026: 6 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 15 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 2
FWCI
0.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
dequalinium chloride, vaginal infection, bacterial vaginosis, vaginal candidiasis, aerobic vaginitis, mixed vaginal infections, clindamycin, antimicrobial resistance, empirical treatment, pregnancy
MeSH terms
Anti-Infective Agents, Local, Anti-Bacterial Agents, Antifungal Agents, Bacteria, Bacteria, Aerobic, Candidiasis, Vulvovaginal, Dequalinium, Female, Humans, Pregnancy, Quality of Life, Vaginal Creams, Foams, and Jellies, Vaginal Diseases, Vaginosis, Bacterial

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