Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 69

The DOI matches its Crossref record.

Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis

Liu, Cheng, Liu, Chongdong, Wang, Qiushi, Zhang, Zhenyu·2018·Archives of Gynecology and Obstetrics
DOI 10.1007/s00404-018-4823-4
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00404-018-4823-4

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 41

  1. Ayansina D, Black C, Hall S, Marks A, Millar C, Prescott G, Wilde K, Bhattacharya S (2016) Long term effects of gestational hypertension and pre-eclampsia on kidney function: record linkage study. Pregnancy Hypertens 6(4):344–349 · DOI
  2. Masoudian P, Nasr A, de Nanassy J, Fung-Kee-Fung K, Bainbridge SA, El Demellawy D (2016) Oocyte donation pregnancies and the risk of preeclampsia or gestational hypertension: a systematic review and metaanalysis. Am J Obstet Gynecol 214(3):328–339 · DOI · Paper page
  3. McGinnis R, Steinthorsdottir V, Williams NO, Thorleifsson G, Shooter S, Hjartardottir S, Bumpstead S, Stefansdottir L, Hildyard L, Sigurdsson JK (2017) Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nat Genet 49(8):1255–1260 · DOI
  4. Al-Jameil N, Khan FA, Khan MF, Tabassum H (2014) A brief overview of preeclampsia. J Clin Med Res 6(1):1 · DOI
  5. Nomura Y, John RM, Janssen AB, Davey C, Finik J, Buthmann J, Glover V, Lambertini L (2017) Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Arch Gynecol Obstet 295(6):1319–1329 · DOI
  6. Garovic VD, Bailey KR, Boerwinkle E, Hunt SC, Weder AB, Curb D, Mosley TH Jr, Wiste HJ, Turner ST (2010) Hypertension in pregnancy as a risk factor for cardiovascular disease later in life. J Hypertens 28(4):826 · DOI
  7. Magnussen EB, Vatten LJ, Smith GD, Romundstad PR (2009) Hypertensive disorders in pregnancy and subsequently measured cardiovascular risk factors. Obstet Gynecol 114(5):961–970 · DOI · Paper page
  8. Roberts JM, Pearson G, Cutler J, Lindheimer M (2003) Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertension 41(3):437–445 · DOI
  9. Sanchez SE, Zhang C, Rene Malinow M, Ware-Jauregui S, Larrabure G, Williams MA (2001) Plasma folate, vitamin B12, and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol 153(5):474–480 · DOI
  10. Vollset SE, Refsum H, Irgens LM, Emblem BM, Tverdal A, Gjessing HK, Monsen ALB, Ueland PM (2000) Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr 71(4):962–968 · DOI
  11. Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong W (2012) Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pract 98(1):151–158 · DOI
  12. Rumbak I, Žižic V, Vrkic N, Baric IC (2015) Folic acid supplementation impact on homocysteine and C-terminal cross-linking telopeptides of type I Collagen. Eur J Nutr Food Saf 5(5):1157–1158 · DOI
  13. Vanderlelie J, Scott R, Shibl R, Lewkowicz J, Perkins A, Scuffham PA (2016) First trimester multivitamin/mineral use is associated with reduced risk of pre-eclampsia among overweight and obese women. Matern Child Nutr 12(2):339–348 · DOI
  14. Wen SW, Guo Y, Rodger M, White RR, Yang Q, Smith GN, Perkins SL, Walker MC (2016) Folic acid supplementation in pregnancy and the risk of pre-eclampsia—a cohort study. PLoS One 11(2):e0149818 · DOI
  15. Wang Y, Zhao N, Qiu J, He X, Zhou M, Cui H, Lv L, Lin X, Zhang C, Zhang H, Xu R, Zhu D, Dang Y, Han X, Zhang H, Bai H, Chen Y, Tang Z, Lin R, Yao T, Su J, Xu X, Liu X, Wang W, Ma B, Liu S, Qiu W, Huang H, Liang J, Wang S, Ehrenkranz RA, Kim C, Liu Q, Zhang Y (2015) Folic acid supplementation and dietary folate intake, and risk of preeclampsia. Eur J Clin Nutr 69(10):1145–1150. https://doi.org/10.1038/ejcn.2014.295 · DOI
  16. Li Z, Ye R, Zhang L, Li H, Liu J, Ren A (2013) Folic acid supplementation during early pregnancy and the risk of gestational hypertension and preeclampsia. Hypertension 61(4):873 · DOI
  17. Higgins JP, Green S (2010) Cochrane Handbook for Systematic Reviews of Interventions. Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie 5(2):S38
  18. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557 · DOI · Paper page
  19. Feng RN, Zhao C, Sun CH, Li Y (2011) Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. PLoS One 6(4):e18480. https://doi.org/10.1371/journal.pone.0018480 · DOI
  20. Bodnar LM, Tang G, Ness RB, Harger G, Roberts JM (2006) Periconceptional multivitamin use reduces the risk of preeclampsia. Am J Epidemiol 164(5):470–477. https://doi.org/10.1093/aje/kwj218 · DOI
  21. Bukowski R, Malone FD, Porter FT, Nyberg DA, Comstock CH, Hankins GDV, Eddleman K, Gross SJ, Dugoff L, Craigo SD (2009) Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med 6(5):e1000061 · DOI
  22. Catov JM, Bodnar LM, Olsen J, Olsen S, Nohr EA (2011) Periconceptional multivitamin use and risk of preterm or small-for-gestational-age births in the Danish National Birth Cohort. Am J Clin Nutr 94(3):906–912 · DOI
  23. Charles DHM, Ness AR, Campbell D, Smith GD, Whitley E, Hall MH (2005) Folic acid supplements in pregnancy and birth outcome: re-analysis of a large randomised controlled trial and update of Cochrane review. Paediatr Perinat Epidemiol 19(2):112–124 · DOI
  24. Hernandez-Diaz S, Werler MM, Louik C, Mitchell AA (2002) Risk of gestational hypertension in relation to folic acid supplementation during pregnancy. Am J Epidemiol 156(9):806–812 · DOI
  25. Kim MW, Ahn KH, Ryu KJ, Hong SC, Lee JS, Nava-Ocampo AA, Oh MJ, Kim HJ (2014) Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes. PLoS One. https://doi.org/10.1371/journal.pone.0097273 · DOI
  26. Liu X, Lv L, Zhang H, Zhao N, Qiu J, He X, Zhou M, Xu X, Cui H, Liu S, Lerro C, Lin X, Zhang C, Zhang H, Xu R, Zhu D, Dang Y, Han X, Bai H, Chen Y, Tang Z, Lin R, Yao T, Su J, Wang W, Wang Y, Ma B, Huang H, Liang J, Qiu W, Liu Q, Zhang Y (2016) Folic acid supplementation, dietary folate intake and risk of preterm birth in China. Eur J Nutr 55(4):1411–1422. https://doi.org/10.1007/s00394-015-0959-1 · DOI
  27. Martinussen MP, Bracken MB, Triche EW, Jacobsen GW, Risnes KR (2015) Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. Eur J Obstet Gynecol Reprod Biol 195:94–99. https://doi.org/10.1016/j.ejogrb.2015.09.022 · DOI
  28. Timmermans S, Jaddoe VW, Silva LM, Hofman A, Raat H, Steegers-Theunissen RP, Steegers EA (2011) Folic acid is positively associated with uteroplacental vascular resistance: the generation R study. Nutr Metab Cardiovasc Dis 21(1):54–61. https://doi.org/10.1016/j.numecd.2009.07.002 · DOI
  29. Wen SW, Chen XK, Rodger M, Rennicks White R, Yang Q, Smith GN, Sigal RJ, Perkins SL, Walker MC (2008) Folic acid supplementation in early second trimester and the risk of preeclampsia. Am J Obstet Gynecol 198(1):41–45. https://doi.org/10.1016/j.ajog.2007.06.067 · DOI
  30. Li Z, Ye R, Zhang L, Li H, Liu J, Ren A (2013) Folic acid supplementation during early pregnancy and the risk of gestational hypertension and preeclampsia. Hypertension 61(4):873–879. https://doi.org/10.1161/HYPERTENSIONAHA.111.00230 · DOI
  31. Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56(2):455–463 · DOI · Paper page
  32. Roberts JM, Cooper DW (2001) Pathogenesis and genetics of pre-eclampsia. Lancet 357(9249):53–56 · DOI
  33. Steegers-Theunissen RPM, Smith SC, Steegers EAP, Guilbert LJ, Baker PN (2000) Folate affects apoptosis in human trophoblastic cells. BJOG 107(12):1513–1515 · DOI
  34. Di SN, Riccardi P, Maggiano N, Piacentani A, D’Asta M, Capelli A, Caruso A (2004) Effect of folic acid on homocysteine-induced trophoblast apoptosis. Mol Hum Reprod 10(9):665–669 · DOI
  35. Catov JM, Nohr EA, Bodnar LM, Knudson VK, Olsen SF, Olsen J (2009) Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort. Am J Epidemiol 169(11):1304–1311 · DOI
  36. Poston L, Briley A, Seed P, Kelly F, Shennan A, Consortium ViP-eT (2006) Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet 367(9517):1145–1154 · DOI · Paper page
  37. Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS (2006) Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med 354(17):1796–1806 · DOI
  38. Lv SS, Wang JY, Wang XQ, Wang Y, Xu Y (2016) Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis. Arch Gynecol Obstet 293(6):1339–1345 · DOI
  39. Ray JG, Mamdani MM (2002) Association between folic acid food fortification and hypertension or preeclampsia in pregnancy. Arch Intern Med 162(15):1776–1777 · DOI
  40. Lumley J, Watson L, Watson M, Bower C (2001) Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects. Cochrane Database Syst Rev 3:CD001056
  41. Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, Sun N, Liu L, Xu X (2007) Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 369(9576):1876–1882 · DOI

Cited by

See all 69

Metadata

Authors
Liu, C., Liu, C., Wang, Q., & Zhang, Z.
ORCID
Liu, Chongdong
Venue
Archives of Gynecology and Obstetrics
Publisher
Springer Science and Business Media LLC
Published
2018-07-05
Volume
298
Issue
4
Pages
697-704
ISSN
  • 0932-0067
  • 1432-0711
DOI
10.1007/s00404-018-4823-4
Cited by
69
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0 (tdm)
Funders
  • International Cooperation Project with Russia (2015DFR31070)
  • Beijing municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201713)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis. https://app.cochat.ai/papers/10.1007/s00404-018-4823-4
The paper
Liu, C., Liu, C., Wang, Q., & Zhang, Z. (2018). Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis. Archives of Gynecology and Obstetrics. https://doi.org/10.1007/s00404-018-4823-4

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.