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Cited by 157Pregnancy and preeclampsia studiesReproductive Health and TechnologiesAssisted Reproductive Technology and Twin Pregnancy

Oocyte donation pregnancies and the risk of preeclampsia or gestational hypertension: a systematic review and metaanalysis

Masoudian, Pourya, Nasr, Ahmed, de Nanassy, Joseph, Fung-Kee-Fung, Karen, Bainbridge, Shannon A., El Demellawy, Dina·2016·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2015.11.020
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Abstract

The purpose of this study was to determine whether pregnancies that were achieved via oocyte donation, compared with pregnancies achieved via other assisted reproductive technology methods or natural conception, demonstrate increased risk of preeclampsia or gestational hypertension. Comparative studies of pregnancies that were achieved with oocyte donation vs other methods of assisted reproductive technology or natural conception with preeclampsia or gestational hypertension were included as 1 of the measured outcomes. Abstracts and unpublished studies were excluded. Two reviewers independently selected studies, which were assessed for quality with the use of methodological index for non-randomized studies, and extracted the data. Statistical analysis was conducted. Of the 523 studies that were reviewed initially, 19 comparative studies met the predefined inclusion and exclusion criteria and were included in the metaanalysis, which allowed for analysis of a total of 86,515 pregnancies. Our pooled data demonstrated that the risk of preeclampsia is higher in oocyte-donation pregnancies compared with other methods of assisted reproductive technology (odds ratio, 2.54; 95% confidence interval, 1.98-3.24; P < .0001) or natural conception (odds ratio, 4.34; 95% confidence interval, 3.10-6.06; P < .0001). The risk of gestational hypertension was also increased significantly in oocyte donation pregnancies in comparison with other methods of assisted reproductive technology (odds ratio, 3.00; 95% confidence interval, 2.44-3.70; P < .0001) or natural conception (odds ratio, 7.94; 95% confidence interval, 1.73-36.36; P = .008). Subgroup analysis that was conducted for singleton and multiple gestations demonstrated a similar risk for preeclampsia and gestational hypertension in both singleton and multiple gestations. This metaanalysis provides further evidence that supports that egg donation increases the risk of preeclampsia and gestational hypertension compared with other assisted reproductive technology methods or natural conception.

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  • There is no evidence that multiple gestations are a significant risk factor for aortic complications, although multiple pregnancies and multiple embryo transfers does lead to an increased risk of hypertension, which might contribute to dissection risk.

    “There is no evidence that multiple gestations are a significant risk factor for aortic complications, although multiple pregnancies and multiple embryo transfers does lead to an increased risk of hypertension, which might contribute to dissection risk.514”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [514]

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Authors
Masoudian, P., Nasr, A., de Nanassy, J., Fung-Kee-Fung, K., Bainbridge, S. A., & El Demellawy, D.
Affiliations
University of Ottawa (CA)
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2016-03
Volume
214
Issue
3
Pages
328-339
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2015.11.020
OpenAlex
W2177935008
Cited by
157
References
69
Citations by year
2026: 8 · 2025: 8 · 2024: 14 · 2023: 8 · 2022: 14 · 2021: 18 · 2020: 19 · 2019: 28 · 2018: 14 · 2017: 16 · 2016: 10
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords
oocyte donation, preeclampsia, gestational hypertension, assisted reproduction, spontaneous conception, pregnancy complications, multiple pregnancy, singleton pregnancy
MeSH terms
Female, Humans, Pre-Eclampsia, Pregnancy, Risk Factors, Odds Ratio, Risk Assessment, Oocyte Donation, Hypertension, Pregnancy-Induced

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