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Cited by 137Multiple Sclerosis Research StudiesPolyomavirus and related diseasesPeripheral Neuropathies and Disorders

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Clinical characteristics of patients with late-onset multiple sclerosis

Kis, B., Rumberg, B., Berlit, P.·2008·Journal of Neurology
DOI 10.1007/s00415-008-0778-x
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Abstract

We evaluated clinical presentation, cerebrospinal fluid (CSF), and magnetic resonance imaging (MRI) in patients with late-onset multiple sclerosis (LOMS). Fifty-two patients with definitive multiple sclerosis (MS) diagnosed after the age of 50 years were identified between 1991 and 2002. Data pertaining to clinical characteristics, CSF analysis, and cerebral and spinal MRI were compared with those of 52 young-onset MS (YOMS) patients matched for sex and disease duration. Mean age at the time of diagnosis was 57 years in the LOMS group - the oldest patient was 82 - and 29 years in the YOMS group. Motor symptoms were significantly more often present in the LOMS than in patients with YOMS (90 % vs. 67 %, p = 0.014). Visual symptoms, residual signs of optic neuritis, and dysarthria were less frequent for LOMS. Sensory symptoms, ataxia, oculomotor symptoms, cognitive disorder, or fatigue did not differ between both groups. The majority of LOMS patients (83 %) had a primary progressive disease course, whereas 94 % of the YOMS group had a relapsing-remitting course. MRI showed typical multifocal supratentorial (LOMS vs. YOMS: 96 % vs. 98 %) and infratentorial (44 % vs. 62 %) lesions without significant group differences. Of particular interest, spinal lesions were more common (81 %) in LOMS compared to YOMS (48 %, p = 0.024), and cerebellar lesions were less frequent in the LOMS group (11 % vs. 44 %, p = 0.001). Gadolinium-enhanced lesions were initially present in less LOMS patient…

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Metadata

Authors
Kis, B., Rumberg, B., & Berlit, P.
Affiliations
Alfried Krupp Hospital (DE)
Corresponding author
Kis, B.
ORCID
Venue
Journal of Neurology
Publisher
Springer Science and Business Media LLC
Published
2008-02-19
Volume
255
Issue
5
Pages
697-702
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
DOI
10.1007/s00415-008-0778-x
OpenAlex
W2082957927
Cited by
137
References
0
Citations by year
2026: 4 · 2025: 15 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 12
FWCI
4.73
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
  • Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords
late-onset multiple sclerosis, age at diagnosis, primary progressive multiple sclerosis, relapsing-remitting multiple sclerosis, motor symptoms, spinal cord lesions, cerebellar lesions, gadolinium-enhancing lesions, pleocytosis, oligoclonal bands, corticosteroid response, clinical course, cerebrospinal fluid
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Brain, Central Nervous System, Diagnostic Errors, Drug Resistance, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Movement Disorders, Multiple Sclerosis, Retrospective Studies, Severity of Illness Index, Spinal Cord, Steroids, Cohort Studies, Age of Onset, Disease Progression, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Oligoclonal Bands

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