Sleep-wake cycle and effects of cabergoline monotherapy in de novo Parkinson’s disease patients: An ambulatory polysomnographic study
Abstract
Objective To investigate the sleep-wake cycle and the effects of cabergoline monotherapy in a homogenous group of de novo Parkinson's Disease (PD) patients without confounding comorbid factors.Design and participants Twelve de novo patients affected by idiopathic PD underwent two ambulatory polysomnographic (APSG)monitoring sessions. The first was performed at baseline, and the second recording one-month after stable treatment with cabergoline monotherapy. Subjective daytime sleepiness was evaluated by means of the Epworth Sleepiness Scale.Data obtained in PD patients at baseline were compared with those obtained in 12 age- and sex-matched healthy subjects.Results Diurnal sleep parameters did not show significant differences between controls and PD patients at baseline. In PD patients, no significant changes in diurnal sleep were observed between baseline and cabergoline treatment. Regarding nocturnal sleep, patients at baseline showed a significantly lower sleep efficiency and a significantly higher Wakefulness After Sleep Onset than controls. With respect to baseline, a significant increase in REM latency and a significant reduction in REM sleep were observed during cabergoline treatment.Conclusions In the early stage of PD, the neurodegenerative process does not seem to be directly responsible for daytime somnolence, but it may be directly involved in the alteration of nocturnal sleep. Cabergoline monotherapy does not affect daytime sleep propensity and, despite clinical improvement, it may have negative effects on REM sleep.
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Reduced amplitude of the rest-activity cycle is present in both de novo and more advanced Parkinson's disease patients, and appears to be independent of the intake of dopaminergic medications.
“This reduced amplitude of the rest-activity cycle is present in both de novo and more advanced patients, and appears to be independent of the intake of dopaminergic medications (Piccini et al., 1991, Placidi et al., 2008, van Hilten et al., 1994, van Hilten et al., 1993, van Hilten et al., 1993).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Placidi et al., 2008
Studies employing actigraphy in the Parkinson's disease population revealed flattening of diurnal activity rhythms and reduced quiescence during night.
“Studies that employed actigraphy in the PD population revealed flattening of the diurnal activity rhythms and reduced quiescence during night (Piccini et al., 1991, Placidi et al., 2008).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Placidi et al., 2008
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- Authors
- Placidi, F., Izzi, F., Romigi, A., Stanzione, P., Marciani, M. G., Brusa, L., Sperli, F., Galati, S., Pasqualetti, P., & Pierantozzi, M.
- Affiliations
- University of Rome Tor Vergata (IT)
- St. Eugenio Hospital (IT)
- Corresponding author
- Placidi, F.
- Venue
- Journal of Neurology
- Published
- 2008-06-02
- Volume
- 255
- Issue
- 7
- Pages
- 1032-1037
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W1567064397
- Cited by
- 21
- References
- 42
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2012: 2
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- Parkinson's disease, cabergoline, monotherapy, sleep-wake cycle, daytime sleepiness, nocturnal sleep, REM sleep, REM latency, sleep efficiency, wake after sleep onset, ambulatory polysomnography, Epworth Sleepiness Scale
- MeSH terms
- Cabergoline, Aged, Antiparkinson Agents, Ergolines, Female, Humans, Male, Middle Aged, Outpatients, Parkinson Disease, Severity of Illness Index, Sleep, Wakefulness, Case-Control Studies, Polysomnography
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