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Cited by 256Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Frequency of dementia, depression, and other neuropsychiatric symptoms in 1,449 outpatients with Parkinson's disease

Riedel, Oliver, Klotsche, Jens, Spottke, Annika, Deuschl, Günther, Förstl, Hans, Henn, Fritz, Heuser, Isabella, Oertel, Wolfgang, Reichmann, Heinz, Riederer, Peter, Trenkwalder, Claudia, Dodel, Richard, Wittchen, Hans-Ulrich·2010·Journal of Neurology
DOI 10.1007/s00415-010-5465-z
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Abstract

Neuropsychiatric symptoms (NPS) of Parkinson's disease (PD) are of growing diagnostic and therapeutic importance. Data on their prevalence and characteristics have been primarily derived from highly selective clinical populations. We have conducted a national study in the outpatient care sector to provide a fuller characterization of the frequency of dementia, depression, and other NPS in PD outpatients. We also examined associations with biosocial and neurological variables. A nationwide representative sample of 1,449 PD outpatients was examined with a standardized clinical interview. PD severity was rated with the Hoehn and Yahr (HY) scale and the Unified Parkinson's Disease Rating Scale. Depression was measured with the Montgomery-Asberg Depression Rating Scale. Cognitive impairment and dementia were assessed with the Mini-Mental State Exam and according to diagnostic criteria. Logistic regression analyses were used to investigate associations. At least one NPS occurred in 71% of all patients with PD. The estimated prevalences (ranges) by age group and HY-stage were: depression, 25% (13.2-47.9%), dementia, 29% (12.2-59.4%), and psychotic syndromes, 12.7% (3.1-40.9%). Other frequent complications were sleep disturbances (49%) and anxiety (20%). Depression was associated with gender but not with age. Dementia was associated with age. The rates and comorbidity of depression and dementia were driven by PD severity. NPS were highly prevalent in our comprehensive patient sample,…

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Metadata

Authors
Riedel, O., Klotsche, J., Spottke, A., Deuschl, G., Förstl, H., Henn, F., Heuser, I., Oertel, W., Reichmann, H., Riederer, P., Trenkwalder, C., Dodel, R., & Wittchen, H.-U.
Affiliations
  • Technische Universität Dresden (DE)
  • University of Bonn (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Technical University of Munich (DE)
  • Brookhaven National Laboratory (US)
  • Charité – Universitätsmedizin Berlin (DE)
  • Philipps University of Marburg (DE)
  • University Hospital Carl Gustav Carus (DE)
  • University of Würzburg (DE)
  • Paracelsus Elena Klinik Kassel (DE)
ORCID
Venue
Journal of Neurology
Publisher
Springer Science and Business Media LLC
Published
2010-02-06
Volume
257
Issue
7
Pages
1073-1082
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
DOI
10.1007/s00415-010-5465-z
OpenAlex
W1999630261
Cited by
256
References
41
Citations by year
2026: 8 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 48 · 2019: 9 · 2018: 14 · 2017: 19 · 2016: 15 · 2015: 12 · 2014: 22 · 2013: 19 · 2012: 11
FWCI
9.93
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
Parkinson's disease, neuropsychiatric symptoms, dementia, depression, psychosis, sleep disorders, anxiety, disease severity, prevalence, Hoehn and Yahr stage, outpatients, comorbidities
MeSH terms
Aged, Mental Disorders, Dementia, Depressive Disorder, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Outpatients, Parkinson Disease, Comorbidity, Prevalence, Age Distribution, Disease Progression

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