Non-motor symptoms of Parkinson's disease: diagnosis and management
Abstract
The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics related to dopamine deficiency that are a consequence of degeneration of the substantia nigra pars compacta. However, non-dopaminergic and non-motor symptoms are sometimes present before diagnosis and almost inevitably emerge with disease progression. Indeed, non-motor symptoms dominate the clinical picture of advanced Parkinson's disease and contribute to severe disability, impaired quality of life, and shortened life expectancy. By contrast with the dopaminergic symptoms of the disease, for which treatment is available, non-motor symptoms are often poorly recognised and inadequately treated. However, attention is now being focused on the recognition and quantitation of non-motor symptoms, which will form the basis of improved treatments. Some non-motor symptoms, including depression, constipation, pain, genitourinary problems, and sleep disorders, can be improved with available treatments. Other non-motor symptoms can be more refractory and need the introduction of novel non-dopaminergic drugs. Inevitably, the development of treatments that can slow or prevent the progression of Parkinson's disease and its multicentric neurodegeneration provides the best hope of curing non-motor symptoms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Non-motor symptoms dominate the clinical picture of Parkinson's disease.
“Indeed, non-motor symptoms dominate the clinical picture of PD”
From Distant delivery of a mindfulness-based intervention for people with Parkinson's disease: The study protocol of a randomised pilot trial (2017) · cites this paper as [2]
Non-motor symptoms contribute to severe disability, impaired quality of life, and shortened life expectancy in Parkinson's disease.
“and contribute to severe disability, impaired quality of life, and shortened life expectancy [2].”
From Distant delivery of a mindfulness-based intervention for people with Parkinson's disease: The study protocol of a randomised pilot trial (2017) · cites this paper as [2]
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
Unified Parkinson's Disease Rating Scale
(2012) · Springer eBooks · doi:10.1007/springerreference_184495 · Cited by 3,071 · see citing works
Parkinson, J. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.2.223 · Cited by 2,684 · see citing works
Recent developments in Parkinson's disease
Fahn, S., Elton, R., MARSDEN, C. D., Calne, D. B., & Goldstein, M. (1986) · Raven Press eBooks · Cited by 2,306 · see citing works
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
Parent, A., & Hazrati, L.-N. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00007-c · Cited by 2,161 · see citing works
Recent Developments in Parkinson's Disease
Hurtig, H. I. (1987) · Neurology · doi:10.1212/wnl.37.5.893 · Cited by 1,926 · see citing works
The Unified Parkinson's Disease Rating Scale (UPDRS): Status and recommendations
Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease (2003) · Movement Disorders · doi:10.1002/mds.10473 · Cited by 1,811 · see citing works
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works
What contributes to quality of life in patients with Parkinson's disease?
Schrag, A. E. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.3.308 · Cited by 1,380 · see citing works
Rivastigmine for Dementia Associated with Parkinson's Disease
Emre, M., Aarsland, D., Albanese, A., Byrne, E. J., Deuschl, G., Deyn, P. P. D., Durif, F., Kulisevsky, J., van Laar, T., Lees, A. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041470 · Cited by 1,219 · see citing works
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187 · see citing works
Reliability, validity, and clinical correlates of apathy in Parkinson's disease
STARKSTEIN, S. E., Mayberg, H. S., Preziosi, T. J., Andrezejewski, P., Leiguarda, R. C., & Robinson, R. G. (1992) · Journal of Neuropsychiatry · doi:10.1176/jnp.4.2.134 · Cited by 1,187 · see citing works
Chaudhuri, K. R., Martinez‐Martin, P., Schapira, A. H. V., Stocchi, F., Sethi, K., Odin, P., Brown, R. G., Koller, W., Barone, P., MacPhee, G., et al. (2006) · Movement Disorders · doi:10.1002/mds.20844 · Cited by 1,100 · see citing works
Self-citationSchenck, C. H., Bundlie, S. R., & Mahowald, M. W. (1996) · Neurology · doi:10.1212/wnl.46.2.388 · Cited by 1,083 · see citing works
Hely, M. A., Morris, J. G. L., Reid, W. G. J., & Trafficante, R. (2005) · Movement Disorders · doi:10.1002/mds.20324 · Cited by 1,050 · see citing works
Rémy, P., Doder, M., Lees, A. J., Turjanski, N., & Brooks, D. J. (2005) · Brain · doi:10.1093/brain/awh445 · Cited by 1,046 · see citing works
Hallucinations in Parkinson's disease: Prevalence, phenomenology and risk factors
Fénelon, G. (2000) · Brain · doi:10.1093/brain/123.4.733 · Cited by 1,035 · see citing works
Gastrointestinal dysfunction in Parkinson's disease
Pfeiffer, R. F. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00307-7 · Cited by 925 · see citing works
Olson, E. J., Boeve, B. F., & Silber, M. H. (2000) · Brain · doi:10.1093/brain/123.2.331 · Cited by 894 · see citing works
Assessment of autonomic dysfunction in Parkinson's disease: The SCOPA‐AUT
Jeukens‐Visser, M., Marinus, J., Stiggelbout, A. M., & van Hilten, J. J. (2004) · Movement Disorders · doi:10.1002/mds.20153 · Cited by 841 · see citing works
Frequency of Bowel Movements and the Future Risk of Parkinson’s Disease
Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001) · Neurology · doi:10.1212/wnl.57.3.456 · Cited by 839 · see citing works
Predictors of Nursing Home Placement in Parkinson's Disease: A Population‐Based, Prospective Study
Aarsland, D., Larsen, J. P., Tandberg, E., & Laake, K. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb06891.x · Cited by 811 · see citing works
Idiopathic hyposmia as a preclinical sign of Parkinson's disease
Ponsen, M. M., Stoffers, D., Booij, J., van Eck‐Smit, B. L. F., Wolters, E. C., & Berendse, H. W. (2004) · Annals of Neurology · doi:10.1002/ana.20160 · Cited by 741 · see citing works
Association of olfactory dysfunction with risk for future Parkinson's disease
Ross, G. W., Petrovitch, H., Abbott, R. D., Tanner, C. M., Popper, J. S., Masaki, K., Launer, L. J., & White, L. R. (2007) · Annals of Neurology · doi:10.1002/ana.21291 · Cited by 739 · see citing works
Pathological gambling is linked to reduced activation of the mesolimbic reward system
Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C. (2005) · Nature Neuroscience · doi:10.1038/nn1378 · Cited by 734 · see citing works
Non-recognition of depression and other non-motor symptoms in Parkinson's disease
Shulman, L. M., Taback, R. L., Rabinstein, A. A., & Weiner, W. J. (2002) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(01)00015-3 · Cited by 695 · see citing works
Falling asleep at the wheel: Motor vehicle mishaps in persons taking pramipexole and ropinirole
Frucht, S. J., Rogers, J., Greene, P., Gordon, M. F., & Fahn, S. (1999) · Neurology · doi:10.1212/wnl.52.9.1908 · Cited by 691 · see citing works
Dementia associated with Parkinson's disease
Emre, M. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00351-x · Cited by 686 · see citing works
Chaudhuri, К. R. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.6.629 · Cited by 676 · see citing works
Systematic evaluation of rating scales for impairment and disability in Parkinson's disease
Ramaker, C. C., Marinus, J., Stiggelbout, A. M., & van Hilten, B. J. (2002) · Movement Disorders · doi:10.1002/mds.10248 · Cited by 664 · see citing works
Nonmotor fluctuations in Parkinson’s disease: Frequent and disabling
Witjas, T., Kaphan, E., Azulay, J. P., Blin, O., Ceccaldi, M., Pouget, J., Poncet, M., & Chérif, A. A. (2002) · Neurology · doi:10.1212/wnl.59.3.408 · Cited by 642 · see citing works
REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease
Gagnon, J., Bédard, M., Fantini, M. L., Petit, D., Panisset, M., Rompré, S., Carrier, J., & Montplaisir, J. Y. (2002) · Neurology · doi:10.1212/wnl.59.4.585 · Cited by 597 · see citing works
Boeve, B. F., Silber, M. H., Ferman, T. J., Lucas, J. A., & Parisi, J. E. (2001) · Movement Disorders · doi:10.1002/mds.1120 · Cited by 597 · see citing works
Peto, V., Jenkinson, C., & Fitzpatrick, R. M. (1998) · Journal of Neurology · doi:10.1007/pl00007730 · Cited by 577 · see citing works
Range of neuropsychiatric disturbances in patients with Parkinson's disease
Aarsland, D., Larsen, J. O., Lim, N. G., Janvin, C. C., Karlsen, K., Tandberg, E., & Cummings, J. L. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.4.492 · Cited by 577 · see citing works
Funkiewiez, A. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2002.009803 · Cited by 568 · see citing works
Cognitive status correlates with neuropathologic stage in Parkinson disease
Braak, H., Rüb, U., Steur, E. N. H. J., Tredici, K. D., & de Vos, R. A. I. (2005) · Neurology · doi:10.1212/01.wnl.0000158422.41380.82 · Cited by 555 · see citing works
Factors impacting on quality of life in Parkinson's disease: Results from an international survey
The Global Parkinson's Disease Survey (GPDS) Steering Committee (2002) · Movement Disorders · doi:10.1002/mds.10010 · Cited by 521 · see citing works
Parkinson’s disease and sleepiness
Arnulf, I., Konofal, É., Merino-Andreu, M., Houéto, J., Mesnage, V., Welter, M., Lacomblez, L., Golmard, J., Derenne, J., & Agid, Y. (2002) · Neurology · doi:10.1212/wnl.58.7.1019 · Cited by 512 · see citing works
Pluck, G. C. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.6.636 · Cited by 473 · see citing works
Laakso, M. P., Partanen, K. P. L., Riekkinen, P., Lehtovirta, M., Helkala, E.-L., Hallikainen, M., Hänninen, T., Vainio, P. A., & Soininen, H. S. (1996) · Neurology · doi:10.1212/wnl.46.3.678 · Cited by 433 · see citing works
Stiasny‐Kolster, K. (2004) · Brain · doi:10.1093/brain/awh322 · Cited by 430 · see citing works
Parkinson Disease Neuropathology
Apaydın, H., Ahlskog, J. E., Parisi, J. E., Boeve, B. F., & Dickson, D. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.102 · Cited by 397 · see citing works
Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder
Eisensehr, I., Linke, R., Noachtar, S., Schwarz, J., Gildehaus, F. J., & Tatsch, K. (2000) · Brain · doi:10.1093/brain/123.6.1155 · Cited by 389 · see citing works
Effect of Psychiatric and Other Nonmotor Symptoms on Disability in Parkinson's Disease
Weintraub, D., Moberg, P. J., Duda, J. E., Katz, I. R., & Stern, M. B. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52219.x · Cited by 381 · see citing works
Goetz, C. G., Poewe, W. H., Rascol, O., & Sampaio, C. (2005) · Movement Disorders · doi:10.1002/mds.20464 · Cited by 376 · see citing works
Olfactory function in patients with Parkinson's disease
Ansari, K. A., & Johnson, A. (1975) · Journal of Chronic Diseases · doi:10.1016/0021-9681(75)90058-2 · Cited by 375 · see citing works
Cardiac Sympathetic Denervation in Parkinson Disease
Goldstein, D. S., Holmes, C., Li, S.-T., Bruce, S., Metman, L. V., & Cannon, R. O. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-5-200009050-00009 · Cited by 372 · see citing works
Singaram, C., Gaumnitz, E., Torbey, C., Ashraf, W., Quigley, E. M., Sengupta, A., & Pfeiffer, R. F. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92707-7 · Cited by 364 · see citing works
Brown, R. G., Dittner, A. J., Findley, L. J. J., & Wessely, S. C. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.07.007 · Cited by 363 · see citing works
Quality of life in patients with Parkinson's disease: development of a questionnaire.
de Boer, A. G. E. M., Wijker, W., Speelman, J. D., & de Haes, J. C. J. M. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.1.70 · Cited by 362 · see citing works
Mattila, P. M., Rinne, J. O., Helenius, H. Y. M., Dickson, D. W., Röyttä, M., & Mattila, P. M. (2000) · Acta Neuropathologica · doi:10.1007/s004019900168 · Cited by 358 · see citing works
Parkin disease: a phenotypic study of a large case series
Khan, N. L., Graham, E., Critchley, P., Schrag, A. E., Wood, N. W., Lees, A. J., Bhatia, K. P., & Quinn, N. P. (2003) · Brain · doi:10.1093/brain/awg142 · Cited by 352 · see citing works
Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease.
Doty, R. L., Stern, M. B., Pfeiffer, C., Gollomp, S. M., & Hurtig, H. I. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.2.138 · Cited by 329 · see citing works
Schrag, A. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.1.67 · Cited by 327 · see citing works
Levodopa-induced psychosis: a kindling phenomenon
Moskovitz, C., Moses, H., & Klawans, H. L. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.6.669 · Cited by 325 · see citing works
Incidental Lewy body disease in a patient with REM sleep behavior disorder
Uchiyama, M., Isse, K., Tanaka, K., Yokota, N., Hamamoto, M., Aida, S., Ito, Y., Yoshimura, M., & Okawa, M. (1995) · Neurology · doi:10.1212/wnl.45.4.709 · Cited by 297 · see citing works
Negative symptoms: the ‘pathology’ of motivation and goal-directed behaviour
Brown, R. G., & Pluck, G. C. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01626-x · Cited by 297 · see citing works
Diederich, N. J., Goetz, C. G., & Stebbins, G. T. (2004) · Movement Disorders · doi:10.1002/mds.20308 · Cited by 290 · see citing works
Olfaction in neurodegenerative disorder
Hawkes, C. H. (2003) · Movement Disorders · doi:10.1002/mds.10379 · Cited by 290 · see citing works
The Rate of Cognitive Decline in Parkinson Disease
Aarsland, D., Andersen, K., Larsen, J. P., Perry, R., Wentzel‐Larsen, T., Lolk, A., & Kragh-Sørensen, P. (2004) · Archives of Neurology · doi:10.1001/archneur.61.12.1906 · Cited by 282 · see citing works
Increased risk of Parkinson’s disease after depression
Schuurman, A. G., van den Akker, M., Ensinck, K., Metsemakers, J. F. M., Knottnerus, J. A., Leentjens, A. F. G., & Buntinx, F. (2002) · Neurology · doi:10.1212/wnl.58.10.1501 · Cited by 270 · see citing works
Assessment of Sleep and Sleepiness in Parkinson Disease
Marinus, J., Jeukens‐Visser, M., van Hilten, J. J., Lammers, G. J., & Stiggelbout, A. M. (2003) · SLEEP · doi:10.1093/sleep/26.8.1049 · Cited by 262 · see citing works
Shouse, M. N., & Siegel, J. M. (1992) · Brain Research · doi:10.1016/0006-8993(92)90508-7 · Cited by 250 · see citing works
Rektorová, I., Rektor, I., Bareš, M., Dostál, V., Ehler, E., Fanfrdlová, Z., Fiedler, J., Klajblová, H., Kulišťák, P., Ressner, P., et al. (2003) · European Journal of Neurology · doi:10.1046/j.1468-1331.2003.00612.x · Cited by 248 · see citing works
Stacy, M. A., Bowron, A., Guttman, M., Hauser, R. A., Hughes, K., Larsen, J. P., LeWitt, P. A., Oertel, W. H., Quinn, N. P., Sethi, K. D., et al. (2005) · Movement Disorders · doi:10.1002/mds.20383 · Cited by 246 · see citing works
The non-motor symptom complex of Parkinson’s disease: A comprehensive assessment is essential
Chaudhuri, К. R., Yates, L. R., & Martínez‐Martín, P. (2005) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-005-0072-6 · Cited by 244 · see citing works
The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism
Pressley, J. C., Louis, E. D., Tang, M. ‐., Cote, L. J., Cohen, P. D., Glied, S., & Mayeux, R. P. (2003) · Neurology · doi:10.1212/wnl.60.1.87 · Cited by 229 · see citing works
Direct economic impact of Parkinson's disease: A research survey in the United Kingdom
Findley, L. J. J., Aujla, M., Bain, P. G., Baker, M. G., Beech, C., Bowman, C., Holmes, J., Kingdom, W. K., MacMahon, D. G., Peto, V., et al. (2003) · Movement Disorders · doi:10.1002/mds.10507 · Cited by 227 · see citing works
Burn, D. J. (2002) · Movement Disorders · doi:10.1002/mds.10114 · Cited by 223 · see citing works
Quinn, N. P., Lang, A. E., Koller, W. C., & MARSDEN, C. D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91674-0 · Cited by 222 · see citing works
Symptoms of autonomic failure in Parkinson?s disease: prevalence and impact on daily life
Magerkurth, C., Schnitzer, R., & Braune, S. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0253-z · Cited by 215 · see citing works
Is fatigue an independent and persistent symptom in patients with Parkinson disease?
Alves, G., Wentzel-Larsen, T., & Larsen, J. P. (2004) · Neurology · doi:10.1212/01.wnl.0000144277.06917.cc · Cited by 215 · see citing works
Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD
Rye, D. B., & Jankovic, J. J. (2002) · Neurology · doi:10.1212/wnl.58.3.341 · Cited by 209 · see citing works
Garcı́a-Borreguero, D., Larrosa, O., & Bravo, M. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0229 · Cited by 203 · see citing works
Sleep attacks and Parkinson's disease treatment
Ferreira, J., Galitzky, M., Montastruc, J., & Rascol, O. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02119-x · Cited by 199 · see citing works
Lai, Y., & Siegel, J. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02727.1990 · Cited by 195 · see citing works
Nondopaminergic mechanisms in levodopa‐induced dyskinesia
Brotchie, J. M. (2005) · Movement Disorders · doi:10.1002/mds.20612 · Cited by 192 · see citing works
Sexual function in patients with Parkinson's disease and their partners.
Brown, R. G., Jahanshahi, M., Quinn, N. P., & MARSDEN, C. D. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.6.480 · Cited by 189 · see citing works
Measuring fatigue in patients with Parkinson's disease – the Fatigue Severity Scale
Herlofson, K., & Larsen, J. O. (2002) · European Journal of Neurology · doi:10.1046/j.1468-1331.2002.00444.x · Cited by 182 · see citing works
Nilsson, F. M., Kessing, L. V., & Bolwig, T. G. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.00372.x · Cited by 180 · see citing works
Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's disease
Pezzella, F. R., Colosimo, C., Vanacore, N., Rezze, S. D., Chianese, M., Fabbrini, G., & Meco, G. (2004) · Movement Disorders · doi:10.1002/mds.20288 · Cited by 154 · see citing works
Elevated Plasma Homocysteine Level in Patients With Parkinson Disease
O’Suilleabhain, P. E., Sung, V., Hernandez, C., Lacritz, L. H., Dewey, R. B., Bottiglieri, T., & Diaz-Arrastia, R. R. (2004) · Archives of Neurology · doi:10.1001/archneur.61.6.865 · Cited by 148 · see citing works
Prospective study of phobic anxiety and risk of Parkinson's disease
Weisskopf, M. G., Chen, H., Schwarzschild, M. A., Kawachi, I. I., & Ascherio, A. (2003) · Movement Disorders · doi:10.1002/mds.10425 · Cited by 145 · see citing works
Apolipoprotein E controls the risk and age at onset of Parkinson disease
Li, Y., Hauser, M. A., Scott, W. K., Martin, E. R., Booze, M. W., Qin, X., Walter, J. W., NANCE, M. A., Hubble, J. P., Koller, W. C., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000128089.53030.ac · Cited by 144 · see citing works
Evaluation of sudomotor function
Low, P. A. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.023 · Cited by 143 · see citing works
Disabling repetitive behaviors in Parkinson's disease
Kurlan, R. (2003) · Movement Disorders · doi:10.1002/mds.10625 · Cited by 142 · see citing works
Beneficial Effects of Testosterone Replacement for the Nonmotor Symptoms of Parkinson Disease
Okun, M. S., Walter, B. L., McDonald, W. M., Tenover, J. L., Green, J., Juncos, J. L., & DeLong, M. R. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1750 · Cited by 136 · see citing works
Association between cardiac denervation and parkinsonism caused by α‐synuclein gene triplication
Singleton, A., Gwinn, K. A., Sharabi, Y., Li, S., Holmes, C. S., Dendi, R., Hardy, J., Singleton, A., Crawley, A., & Goldstein, D. S. (2004) · Brain · doi:10.1093/brain/awh081 · Cited by 136 · see citing works
Incidence of RBD and hallucination in patients affected by Parkinson's disease: 8-year follow-up
ONOFRJ, M. C., Thomas, A., D’Andreamatteo, G., Iacono, D., Luciano, A. L., Rollo, A. D., Mascio, R. D., Ballone, E., & Iorio, A. D. (2002) · Neurological Sciences · doi:10.1007/s100720200085 · Cited by 131 · see citing works
Karachi, C., Yelnik, J., Tandé, D., Tremblay, L., Hirsch, É. C., & François, C. (2004) · Movement Disorders · doi:10.1002/mds.20302 · Cited by 130 · see citing works
Idiopathic REM sleep behavior disorder
Fantini, M. L., Ferini‐Strambi, L., & Montplaisir, J. Y. (2005) · Neurology · doi:10.1212/01.wnl.0000152878.79429.00 · Cited by 128 · see citing works
Resource use and costs in a Swedish cohort of patients with Parkinson's disease
Hagell, P., Nordling, S., Reimer, J., Grabowski, M., & Persson, U. (2002) · Movement Disorders · doi:10.1002/mds.10262 · Cited by 123 · see citing works
Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease
Khan, N. L., Katzenschlager, R., Watt, H., Bhatia, K. P., Wood, N. W., Quinn, N. P., & Lees, A. J. (2004) · Neurology · doi:10.1212/01.wnl.0000118281.66802.81 · Cited by 120 · see citing works
Development and testing of the Parkinson's disease quality of life scale
Welsh, M. D., McDermott, M., Holloway, R. G., Plumb, S., Pfeiffer, R. F., & Hubble, J. P. (2003) · Movement Disorders · doi:10.1002/mds.10424 · Cited by 117 · see citing works
Mahieux, F., Michelet, D., Manifacier, M.-J., Boller, F., Fermanian, J., & Guillard, A. (1995) · Behavioural Neurology · doi:10.1155/1995/304876 · Cited by 116 · see citing works
Are Patients with Parkinson's Disease Suicidal?
Myslobodsky, M. S., Lalonde, F. M., & HICKS, L. H. (2001) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198870101400304 · Cited by 114 · see citing works
Oral and genital pain syndromes in Parkinson's disease
Ford, B., Louis, E. D., Greene, P. E., & Fahn, S. (1996) · Movement Disorders · doi:10.1002/mds.870110411 · Cited by 110 · see citing works
Rye, D. B. (2004) · Neurology · doi:10.1212/wnl.63.8_suppl_3.s2 · Cited by 108 · see citing works
The Value of Urethral Sphincter Electromyography in the Differential Diagnosis of Parkinsonism
Ian Eardley, C., Quinn, N. P., Fowler, C. J., Kirby, R. S., PARKHOUSE, H. F., MARSDEN, C. D., & Bannister, R. (1989) · British Journal of Urology · doi:10.1111/j.1464-410x.1989.tb06043.x · Cited by 106 · see citing works
A short psychosocial questionnaire for patients with Parkinson's disease
Marinus, J., Jeukens‐Visser, M., Martı́nez-Martı́n, P., van Hilten, J. J., & Stiggelbout, A. M. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00569-3 · Cited by 105 · see citing works
Kipps, C., Fung, V. S. C., Grattan‐Smith, P. J., de Moore, G. M., & Morris, J. G. (2004) · Movement Disorders · doi:10.1002/mds.20325 · Cited by 97 · see citing works
Longitudinal evaluation of economic and physical impact of Parkinson's disease
Schenkman, M. L., Zhu, C. W., Cutson, T. M., & Whetten‐Goldstein, K. (2001) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(00)00079-1 · Cited by 90 · see citing works
Mahieux, F., Michelet, D., Manifacier, M.-J., et al. (1995) · PubMed · doi:10.3233/ben-1995-8102 · Cited by 89 · see citing works
Abnormal performance on the PD test battery by asymptomatic first-degree relatives
Montgomery, E. B., Baker, K. B., Lyons, K., & Koller, W. C. (1999) · Neurology · doi:10.1212/wnl.52.4.757 · Cited by 89 · see citing works
Reduced reward processing in the brains of Parkinsonian patients
Künig, G., Leenders, K. L., Martin-Söelch, C., Missimer, J. H., Magyar‐Lehmann, S., & Schultz, W. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00019 · Cited by 85 · see citing works
Ahlskog, J. E. (2004) · Movement Disorders · doi:10.1002/mds.20362 · Cited by 83 · see citing works
Autonomic dysfunction in movement disorders
Chaudhuri, К. R. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200108000-00012 · Cited by 82 · see citing works
Sudden daytime sleep onset in Parkinson's disease: Polysomnographic recordings
Tracik, F. M., & Ebersbach, G. (2001) · Movement Disorders · doi:10.1002/mds.1083 · Cited by 80 · see citing works
Left-sided Parkinson's disease is associated with greater anxiety and depression
Fleminger, S. (1991) · Psychological Medicine · doi:10.1017/s0033291700022261 · Cited by 78 · see citing works
Andreu, N., Chalé, J.-J., Sénard, J., Thalamas, C., Montastruc, J., & Rascol, O. (1999) · PubMed · Cited by 78 · see citing works
Differential DSM-III Psychiatric Disorder Prevalence Profiles in Dystonia and Parkinson's Disease
Lauterbach, E. C., Freeman, A., & Vogel, R. L. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.1.29 · Cited by 78 · see citing works
Evaluation of the Short Parkinsonʼs Evaluation Scale
Rabey, J. M., Bass, H., Bonuccelli, U., Brooks, D. J., Klotz, P., Korczyn, A. D., Kraus, P., Martinez-Martin, P., Morrish, P., Sauten, W. V., et al. (1997) · Clinical Neuropharmacology · doi:10.1097/00002826-199708000-00004 · Cited by 77 · see citing works
Andreu, N., Chalé, J.-J., Sénard, J., Thalamas, C., Montastruc, J., & Rascol, O. (1999) · Clinical Neuropharmacology · doi:10.1097/00002826-199901000-00004 · Cited by 76 · see citing works
Nocturnal symptom complex in PD and its management
Chaudhuri, К. R. (2003) · Neurology · doi:10.1212/wnl.61.6_suppl_3.s17 · Cited by 74 · see citing works
Polysomnographic characterization of pergolide-induced sleep attacks in idiopathic PD
Ulivelli, M., Rossi, S., Lombardi, C., Bartalini, S., Rocchi, R., Giannini, F., Passero, S. G., Battistini, N., & Lugaresi, E. (2002) · Neurology · doi:10.1212/wnl.58.3.462 · Cited by 71 · see citing works
Gastrointestinal Dysfunction in Parkinson???s Disease
Byrne, K. G., Pfeiffer, R. F., & Quigley, E. M. M. (1994) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199407000-00004 · Cited by 70 · see citing works
Neuropsychiatric non-motor aspects of Parkinson’s disease
Thanvi, B., Munshi, S. K., Vijaykumar, N. A., & Lo, T. C. N. (2003) · Postgraduate Medical Journal · doi:10.1136/pmj.79.936.561 · Cited by 66 · see citing works
Pain in Parkinson's disease: Common yet seldom recognized symptom is treatable
Waseem, S., & Gwinn-Hardy, K. (2001) · Postgraduate Medicine · doi:10.3810/pgm.2001.12.1063 · Cited by 54 · see citing works
Genetic Polymorphisms in Parkinson Disease Subjects With and Without Hallucinations
Goldman, J. G., Goetz, C. G., Berry‐Kravis, E., Leurgans, S. E., & Zhou, L. (2004) · Archives of Neurology · doi:10.1001/archneur.61.8.1280 · Cited by 53 · see citing works
Excessive daytime sleepiness in Parkinson’s disease
Schapira, A. H. V. (2004) · Neurology · doi:10.1212/wnl.63.8_suppl_3.s24 · Cited by 47 · see citing works
Self-citationGrowth hormone response to clonidine in central and peripheral primary autonomic failure
Thomaides, T., Chaudhuri, К. R., Maule, S. V., Watson, L. P. E., Mathias, C. J., & MARSDEN, C. D. (1992) · The Lancet · doi:10.1016/0140-6736(92)92355-j · Cited by 44 · see citing works
Dimensions of Sexual Dysfunction in Parkinson Disease
Yu, M., Roane, D. M., Miner, C. R., Fleming, M. P., & Rogers, J. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200403000-00013 · Cited by 41 · see citing works
Pramipexole, Ropinirole, and Mania in Parkinson’s Disease
Singh, A. K., Althoff, R. R., MARTINEAU, R. J., & JACOBSON, J. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.814-a · Cited by 39 · see citing works
Clinical features and evaluation of the primary chronic autonomic failure syndromes
Bannister, R. (1999) · UCL Discovery (University College London) · Cited by 36 · see citing works
Molecular Mechanisms of Parkinson's Disease
Rezaee, Z., Marandi, M., Alaei, H., & Esfarjani, F. (2019) · The Neuroscience Journal of Shefaye Khatam · doi:10.29252/shefa.8.1.120 · Cited by 30 · see citing works
Parkinson's disease and quality of life: issues and challenges beyond motor symptoms
Welsh, M. D. (2004) · Neurologic Clinics · doi:10.1016/j.ncl.2004.05.003 · Cited by 20 · see citing works
Desirable properties for instruments assessing quality of life: evidence from the PDQ-39.
Fitzpatrick, R. M., Jenkinson, C., Peto, V., Hyman, N., & Greenhall, R. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.1.104 · Cited by 19 · see citing works
Cummings, J. L. (2004) · PubMed · Cited by 11 · see citing works
Why Excessive Daytime Sleepiness is an Important Issue in Parkinson's Disease
MacMahon, D. (2005) · Cited by 8 · see citing works
Sleep attacks in Parkinson's disease
Ferreira, J. J., Galitzky, M., Montastruc, J., & Rascol, O. (2000) · The Lancet · doi:10.1016/s0140-6736(05)73982-9 · Cited by 7 · see citing works
Addressing non-motor impairments in Parkinson's disease: The new version of the UPDRS
Dodel, R. C., Dubois, B., Fahn, S., Cg, G., Holloway, R., Jankovic, L., Kulisevsky, J., Lang, A. E., Lees, A. J., Leurgans, S. E., et al. (2005) · UCL Discovery (University College London) · Cited by 6 · see citing works
Correlation of Parkinson's disease severity and duration with123I-FP-CIT SPECT striatal uptake
Benamer, H. T. S., Patterson, J., Wyper, D. J., Hadley, D. M., Macphee, G. J. A., & Grosset, D. G. (2000) · Movement Disorders · doi:10.1002/1531-8257(200007)15:4
Flagged first, then by citations
2 of the 140 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Non-motor features of Parkinson disease
Schapira, A. H. V., Chaudhuri, K. R., & Jenner, P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.62 · Cited by 2,053 · see citing works
Self-citationNon-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
Chaudhuri, К. R., & Schapira, A. H. V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70068-7 · Cited by 1,739 · see citing works
Self-citationBarone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., et al. (2009) · Movement Disorders · doi:10.1002/mds.22643 · Cited by 1,445 · see citing works
Chaudhuri, К. R., Martínez‐Martín, P., Brown, R. G., Sethi, K. D., Stocchi, F., Odin, P., Ondo, W. G., Abe, K., Macphee, G. J. A., MacMahon, D., et al. (2007) · Movement Disorders · doi:10.1002/mds.21596 · Cited by 1,090 · see citing works
Self-citationMartínez‐Martín, P., Rodríguez‐Blázquez, C., Kurtis, M. M., Chaudhuri, К. R., & on Behalf of the NMSS Validation Group (2011) · Movement Disorders · doi:10.1002/mds.23462 · Cited by 1,003 · see citing works
Evolution of cognitive dysfunction in an incident Parkinson's disease cohort
Williams‐Gray, C. H., Foltynie, T., Brayne, C., Robbins, T. W., & Barker, R. (2007) · Brain · doi:10.1093/brain/awm111 · Cited by 935 · see citing works
Shippee, N. D., Shah, N. D., May, C. R., Mair, F. S., & Montori, V. M. (2012) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.05.005 · Cited by 728 · see citing works
Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 603 · see citing works
A timeline for Parkinson's disease
Hawkes, C. H., Del Tredici, K., & Braak, H. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.08.007 · Cited by 594 · see citing works
Martínez‐Martín, P., Schapira, A. H. V., Stocchi, F., Sethi, K. D., Odin, P., Macphee, G. J. A., Brown, R. G., Naidu, Y., Clayton, L. M. S., Abe, K., et al. (2007) · Movement Disorders · doi:10.1002/mds.21586 · Cited by 556 · see citing works
Self-citationParkinson’s Disease: Etiology, Neuropathology, and Pathogenesis
Kouli, A., Torsney, K., & Kuan, W. (2018) · Codon Publications eBooks · doi:10.15586/codonpublications.parkinsonsdisease.2018.ch1 · Cited by 556 · see citing works
Invited Article: Nervous system pathology in sporadic Parkinson disease
Braak, H., & Tredici, K. D. (2008) · Neurology · doi:10.1212/01.wnl.0000312279.49272.9f · Cited by 536 · see citing works
Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
Klingelhoefer, L., & Reichmann, H. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.197 · Cited by 598 · see citing works
Neurotoxin-based models of Parkinson's disease
Bové, J., & Perier, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.057 · Cited by 508 · see citing works
Classic and New Animal Models of Parkinson's Disease
Blesa, J., Phani, S., Jackson-Lewis, V. R., & Przedborski, S. (2012) · BioMed Research International · doi:10.1155/2012/845618 · Cited by 502 · see citing works
Gallagher, D. A., Lees, A. J., & Schrag, A. E. (2010) · Movement Disorders · doi:10.1002/mds.23394 · Cited by 506 · see citing works
Pain in Parkinson’s disease: Prevalence and characteristics
Beiske, A. G., Loge, J. H., Rønningen, A., & Svensson, E. (2008) · Pain · doi:10.1016/j.pain.2008.12.004 · Cited by 505 · see citing works
Dysphagia in Parkinson’s Disease
Suttrup, I., & Warnecke, T. (2015) · Dysphagia · doi:10.1007/s00455-015-9671-9 · Cited by 510 · see citing works
Hypocretin (orexin) loss in Parkinson's disease
Fronczek, R., Overeem, S., Lee, S. Y. Y., Hegeman, I. M., van Pelt, J., van Duinen, S. G., Lammers, G. J., & Swaab, D. F. (2007) · Brain · doi:10.1093/brain/awm090 · Cited by 463 · see citing works
The Role of Autophagy in Parkinson's DiseasePreprint
Lynch-Day, M. A., Mao, K., Wang, K., Zhao, M., & Klionsky, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009357 · Cited by 459 · see citing works
Mhyre, T. R., Boyd, J. T., Hamill, R. W., & Maguire‐Zeiss, K. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_16 · Cited by 442 · see citing works
Priorities in Parkinson's disease research
Meissner, W. G., Frasier, M. A., Gasser, T., Goetz, C. G., Lozano, A. M., Piccini, P. P., Obeso, J. A., Rascol, O., Schapira, A. H. V., Voon, V., et al. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3430 · Cited by 439 · see citing works
Self-citationLebouvier, T., Neunlist, M., Bruley des Varannes, S., Coron, E., Drouard, A., N'Guyen, J.-M., Chaumette, T., Tasselli, M., Paillusson, S., Flamand, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012728 · Cited by 427 · see citing works
Chaudhuri, К. R., Prieto‐Jurcynska, C., Naidu, Y., Mitra, T., Payo, B. F., Tluk, S., Ruessmann, A., Odin, P., Macphee, G. J. A., Stocchi, F., et al. (2010) · Movement Disorders · doi:10.1002/mds.22868 · Cited by 431 · see citing works
Self-citationFerroptosis Mechanisms Involved in Neurodegenerative Diseases
Reichert, C. O., de Freitas, F. A., Sampaio‐Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228765 · Cited by 426 · see citing works
Li, W., Wu, X., Hu, X., Wang, T., Liang, S., Duan, Y., Jin, F., & Qin, B. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9001-4 · Cited by 406 · see citing works
Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Henrich, M. T., Oertel, W. H., Surmeier, D. J., & Geibl, F. F. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00676-7 · Cited by 435 · see citing works
Depression and Parkinson’s Disease: Current Knowledge
Marsh, L. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0409-5 · Cited by 407 · see citing works
Review: Sporadic Parkinson's disease: development and distribution ofα‐synuclein pathology
Tredici, K. D., & Braak, H. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12298 · Cited by 396 · see citing works
Parkinson’s disease: The non-motor issues
Chaudhuri, К. R., Odin, P., Antonini, A., & Martínez‐Martín, P. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.02.018 · Cited by 390 · see citing works
Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism
Schrag, A. E., & Schott, J. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70411-2 · Cited by 385 · see citing works
Ma, K., Xiong, N., Shen, Y., Han, C., Liu, L., Zhang, G., Wang, L., Guo, S., Guo, X., Xia, Y. F., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00001 · Cited by 379 · see citing works
Non motor subtypes and Parkinson's disease
Sauerbier, A., Jenner, P. G., Todorova, A., & Chaudhuri, К. R. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.09.027 · Cited by 377 · see citing works
Nonmotor fluctuations in Parkinson disease
Storch, A., Schneider, C. B., Wolz, M., Stürwald, Y., Nebe, A., Odin, P., Mahler, A., Fuchs, G., Jost, W. H., Chaudhuri, К. R., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e318285c0ed · Cited by 373 · see citing works
Montgomery, S. L., & Bowers, W. J. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9287-2 · Cited by 365 · see citing works
A pathophysiological model of freezing of gait in Parkinson's disease
Lewis, S. J. G., & Barker, R. A. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.08.006 · Cited by 343 · see citing works
Nonmotor features of Parkinson's disease subtypes
Marras, C., & Chaudhuri, К. R. (2016) · Movement Disorders · doi:10.1002/mds.26510 · Cited by 327 · see citing works
The mutual interplay of gut microbiota, diet and human disease
Illiano, P., Brambilla, R., & Parolini, C. (2020) · FEBS Journal · doi:10.1111/febs.15217 · Cited by 331 · see citing works
Braak, H., Sastre, M., Böhl, J., de Vos, R. A. I., & Tredici, K. D. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0193-x · Cited by 320 · see citing works
How to make a midbrain dopaminergic neuron
Arenas, E., Denham, M., & Villaescusa, C. (2015) · Development · doi:10.1242/dev.097394 · Cited by 306 · see citing works
Serotonin in Parkinson's disease
Politis, M., & Niccolini, F. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.037 · Cited by 307 · see citing works
The Brainstem Pathologies of Parkinson's Disease and Dementia with Lewy Bodies
Seidel, K., Mahlke, J., Siswanto, S., Krüger, R., Heinsen, H., Auburger, G. W. J., Bouzrou, M., Grinberg, L. T., Wicht, H., Korf, H., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12168 · Cited by 301 · see citing works
Emerging therapies in Parkinson disease — repurposed drugs and new approaches
Elkouzi, A., Vedam‐Mai, V., Eisinger, R. S., & Okun, M. S. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0155-7 · Cited by 304 · see citing works
Novel pharmacological targets for the treatment of Parkinson's disease
Schapira, A. H. V., Bézard, E., Brotchie, J. M., Calon, F., Collingridge, G. L., Ferger, B., Hengerer, B., Hirsch, É. C., Jenner, P. G., Novère, N. G. L., et al. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2087 · Cited by 299 · see citing works
Self-citationSzewczyk‐Królikowski, K., Tomlinson, P. R., Nithi, K. A., Wade‐Martins, R., Talbot, K., Ben‐Shlomo, Y., & Hu, M. T. M. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.09.025 · Cited by 293 · see citing works
α-Synuclein pathology in Parkinson’s disease and related α-synucleinopathies
Henderson, M. X., Trojanowski, J. Q., & Lee, V. M. ‐. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134316 · Cited by 291 · see citing works
Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease
Church, F. (2021) · Biomolecules · doi:10.3390/biom11040612 · Cited by 303 · see citing works
Nonmotor symptoms as presenting complaints in Parkinson’s disease: a clinicopathological study
O'Sullivan, S. S., Williams, D. R., Gallagher, D. A., Massey, L. A., Silveira‐Moriyama, L., & Lees, A. J. (2008) · Movement Disorders · doi:10.1002/mds.21813 · Cited by 290 · see citing works
Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease
Vascellari, S., Palmas, V., Melis, M., Pisanu, S., Cusano, R., Uva, P., Perra, D., Madau, V., Sarchioto, M., Oppo, V., et al. (2020) · mSystems · doi:10.1128/msystems.00561-20 · Cited by 291 · see citing works
Pathological correlates of gastrointestinal dysfunction in Parkinson's disease
Cersosimo, M. G., & Benarroch, E. E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.014 · Cited by 284 · see citing works
REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia
Vendette, M., Gagnon, J., Décary, A., Massicotte-Marquez, J., Postuma, R. B., Doyon, J., Panisset, M., & Montplaisir, J. Y. (2007) · Neurology · doi:10.1212/01.wnl.0000278114.14096.74 · Cited by 281 · see citing works
Patient-reported autonomic symptoms in Parkinson disease
Verbaan, D., Marinus, J., Jeukens‐Visser, M., van Rooden, S. M., Stiggelbout, A. M., & van Hilten, J. J. (2007) · Neurology · doi:10.1212/01.wnl.0000266593.50534.e8 · Cited by 283 · see citing works
Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease
Martínez‐Martín, P., Falup‐Pecurariu, C., Odin, P., van Hilten, J. J., Antonini, A., Rojo-Abuín, J. M., Borges, V., Trenkwalder, C., Aarsland, D., Brooks, D. J., et al. (2012) · Journal of Neurology · doi:10.1007/s00415-011-6392-3 · Cited by 285 · see citing works
Deep learning based diagnosis of Parkinson’s disease using convolutional neural network
Sivaranjini, S., & Sujatha, C. M. (2019) · Multimedia Tools and Applications · doi:10.1007/s11042-019-7469-8 · Cited by 282 · see citing works
Epidemiology of psychosis in Parkinson's disease
Fénelon, G., & Alves, G. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.08.014 · Cited by 330 · see citing works
Mishra, A., Singh, S., & Shukla, S. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518779829 · Cited by 276 · see citing works
Fontana, B. D., Mezzomo, N. J., Kalueff, A. V., & Rosemberg, D. B. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.004 · Cited by 273 · see citing works
Honig, H., Antonini, A., Martínez‐Martín, P., Forgács, I., Chung‐Faye, G., Fox, T., Fox, K., Mancini, F., Canesi, M., Odin, P., et al. (2009) · Movement Disorders · doi:10.1002/mds.22596 · Cited by 272 · see citing works
King's Parkinson's disease pain scale, the first scale for pain in PD: An international validation
Chaudhuri, К. R., Rizos, A., Trenkwalder, C., Rascol, O., Pal, S., Martino, D., Carroll, C., Paviour, D. C., Falup‐Pecurariu, C., Kessel, B., et al. (2015) · Movement Disorders · doi:10.1002/mds.26270 · Cited by 271 · see citing works
The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders
Pawelec, P., Ziemka‐Nałęcz, M., Sypecka, J., & Zalewska, T. (2020) · Cells · doi:10.3390/cells9102277 · Cited by 272 · see citing works
Depression in neurodegenerative diseases: Common mechanisms and current treatment options
Galts, C., Bettio, L. E. B., Jewett, D. C., Yang, C. C., Brocardo, P. S., Rodrigues, A. L. S., Thacker, J. S., & Gil‐Mohapel, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.002 · Cited by 268 · see citing works
Martínez‐Martín, P., Rodríguez‐Blázquez, C., Abe, K., Bhattacharyya, K., Bloem, B. R., Carod-Artal, F. J., Prakash, R., Esselink, R. A. J., Falup‐Pecurariu, C., Gallardo, M., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c0d416 · Cited by 263 · see citing works
Postuma, R. B., Gagnon, J., Vendette, M., & Montplaisir, J. Y. (2009) · Brain · doi:10.1093/brain/awp244 · Cited by 261 · see citing works
Diagnosis and the premotor phase of Parkinson disease
TOLOSA, E. S., Gaig, C., Santamaría, J., & Compta, Y. (2009) · Neurology · doi:10.1212/wnl.0b013e318198db11 · Cited by 257 · see citing works
Riedel, O., Klotsche, J., Spottke, A., Deuschl, G., Förstl, H., Henn, F., Heuser, I., Oertel, W., Reichmann, H., Riederer, P., et al. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5465-z · Cited by 256 · see citing works
Norepinephrine: The redheaded stepchild of Parkinson's disease
Rommelfanger, K. S., & Weinshenker, D. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.01.036 · Cited by 255 · see citing works
Martínez‐Martín, P., Rodríguez‐Blázquez, C., Álvarez, M., Arakaki, T., Bergareche‐Yarza, A., Chade, A. R., Garretto, N., Gershanik, O. S., Kurtis, M. M., Martínez‐Castrillo, J. C., et al. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6624-1 · Cited by 254 · see citing works
Premotor, nonmotor and motor symptoms of Parkinson's Disease: A new clinical state of the art
Silva, A. B. R. L., de Oliveira, R. W. G., Diógenes, G. P., Aguiar, M. F. D. C., Sallem, C. C., Lima, M. P. P., Filho, L. B. D. A., de Medeiros, S. D. P., de Mendonça, L. L. P., Filho, P. C. D. S., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101834 · Cited by 252 · see citing works
Neurobiology and treatment of Parkinson's disease
Schapira, A. H. V. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.005 · Cited by 252 · see citing works
Self-citationCoelho, M. M., & Ferreira, J. J. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.126 · Cited by 250 · see citing works
Neuroimaging in Parkinson disease: from research setting to clinical practice
Politis, M. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.205 · Cited by 247 · see citing works
Schwingenschuh, P., Ruge, D., Edwards, M. J., Terranova, C., Katschnig, P., Carrillo, F., Silveira‐Moriyama, L., Schneider, S. A., Kägi, G., Palomar, F. J., et al. (2010) · Movement Disorders · doi:10.1002/mds.23019 · Cited by 248 · see citing works
Martínez‐Martín, P., Reddy, P., Katzenschlager, R., Antonini, A., Todorova, A., Odin, P., Henriksen, T., Martin, A., Calandrella, D., Rizos, A., et al. (2014) · Movement Disorders · doi:10.1002/mds.26067 · Cited by 252 · see citing works
Benskey, M. J., Perez, R. G., & Manfredsson, F. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13570 · Cited by 247 · see citing works
Disrupted brain network topology in Parkinson’s disease: a longitudinal magnetoencephalography study
Dubbelink, K. T. E. O., Hillebrand, A., Stoffers, D., Deijen, J. B., Twisk, J. W. R., Stam, C. J., & Berendse, H. W. (2013) · Brain · doi:10.1093/brain/awt316 · Cited by 244 · see citing works
Ehrt, U., Broich, K., Larsen, J. O., Ballard, C. G., & Aarsland, D. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.186239 · Cited by 247 · see citing works
Staging of serotonergic dysfunction in Parkinson's Disease: An in vivo 11C-DASB PET study
Politis, M., Wu, K., Loane, C., Kiferle, L., Molloy, S., Brooks, D. J., & Piccini, P. P. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.028 · Cited by 242 · see citing works
Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa
Smith, Y., Wichmann, T., Factor, S. A., & DeLong, M. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.212 · Cited by 246 · see citing works
Cognitive impairment in Parkinson's disease
Verbaan, D., Marinus, J., Jeukens‐Visser, M., van Rooden, S. M., Stiggelbout, A. M., Middelkoop, H. A. M., & van Hilten, J. J. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.112367 · Cited by 240 · see citing works
The identification of Parkinson's disease subtypes using cluster analysis: A systematic review
van Rooden, S. M., Heiser, W. J., Kok, J. N., Verbaan, D., van Hilten, J. J., & Marinus, J. (2010) · Movement Disorders · doi:10.1002/mds.23116 · Cited by 238 · see citing works
The clinical heterogeneity of Parkinson's disease and its therapeutic implications
Greenland, J. C., Williams‐Gray, C. H., & Barker, R. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14094 · Cited by 239 · see citing works
Classification of Parkinson's Disease Gait Using Spatial-Temporal Gait Features
Wahid, F., Begg, R. K., Hass, C. J., Halgamuge, S. K., & Ackland, D. C. (2015) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2015.2450232 · Cited by 235 · see citing works
Nonmotor manifestations of Parkinson's disease
Simuni, T., & Sethi, K. D. (2009) · Annals of Neurology · doi:10.1002/ana.21472 · Cited by 236 · see citing works
Parkinson’s: a syndrome rather than a disease?
Titova, N., Padmakumar, C., Lewis, S. J. G., & Chaudhuri, К. R. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1667-6 · Cited by 234 · see citing works
The Cambridge Behavioural Inventory revised
Wear, H. J., Wedderburn, C. J., Mioshi, E., Williams-Gray, C. H., Mason, S. L., Barker, R. A., & Hodges, J. R. (2008) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642009dn20200005 · Cited by 225 · see citing works
Parkinson's disease--Part 1: Pathophysiology, symptoms, burden, diagnosis, and assessment.
Weintraub, D. A., Comella, C. L., & Horn, S. S. (2008) · PubMed · Cited by 230 · see citing works
Boersma, I. M., Miyasaki, J. M., Kutner, J. S., & Kluger, B. M. (2014) · Neurology · doi:10.1212/wnl.0000000000000674 · Cited by 232 · see citing works
Development of allosteric modulators of GPCRs for treatment of CNS disorders
Nickols, H. H., & Conn, P. J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.09.013 · Cited by 227 · see citing works
Clinical subtypes of Parkinson's disease
van Rooden, S. M., Colas, F., Martínez‐Martín, P., Jeukens‐Visser, M., Verbaan, D., Marinus, J., Chaudhuri, К. R., Kok, J. N., & van Hilten, J. J. (2010) · Movement Disorders · doi:10.1002/mds.23346 · Cited by 228 · see citing works
Chen, J., & Cunha, R. A. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09694-2 · Cited by 228 · see citing works
The therapeutic potential of interleukin-10 in neuroimmune diseases
Kwilasz, A. J., Grace, P. M., Šerbedžija, P., Maier, S. F., & Watkins, L. R. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.020 · Cited by 235 · see citing works
Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies
Villar‐Piqué, A., da Fonseca, T. L., & Outeiro, T. F. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13249 · Cited by 226 · see citing works
Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems
Brichta, L., Greengard, P., & Flajolet, M. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.003 · Cited by 224 · see citing works
Neurotransmission in Parkinson’s disease: beyond dopamine
Barone, P. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02900.x · Cited by 222 · see citing works
Gender differences in Parkinson’s disease: A clinical perspective
Georgiev, D., Hamberg, K., Hariz, M., Forsgren, L., & Hariz, G.-M. (2017) · Acta Neurologica Scandinavica · doi:10.1111/ane.12796 · Cited by 220 · see citing works
Progress in unraveling the genetic etiology of Parkinson disease in a genomic era
Verstraeten, A., Theuns, J., & Van Broeckhoven, C. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.01.004 · Cited by 226 · see citing works
Prevalence of pain in Parkinson's disease: A systematic review using the modified QUADAS tool
Broen, M. P. G., Braaksma, M. M., Patijn, J., & Weber, W. E. J. (2012) · Movement Disorders · doi:10.1002/mds.24054 · Cited by 220 · see citing works
Pinton, S., Sampaio, T. B., Savall, A. S. P., & Gutierrez, M. Z. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.205084 · Cited by 219 · see citing works
MAO-inhibitors in Parkinson's Disease
Riederer, P. F., & Laux, G. (2011) · Experimental Neurobiology · doi:10.5607/en.2011.20.1.1 · Cited by 218 · see citing works
Temel, Y., Boothman, L. J., Blokland, A., Magill, P. J., Steinbusch, H. W. M., Visser-Vandewalle, V. E. R. M., & Sharp, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704144104 · Cited by 214 · see citing works
- Authors
- Chaudhuri, K. R., Healy, D. G., & Schapira, A. H.
- Affiliations
- Guy's and St Thomas' NHS Foundation Trust (GB)
- The Royal Free Hospital (GB)
- ORCID
- Schapira, Anthony HV
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 5
- Issue
- 3
- Pages
- 235-245
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W1982535961
- Cited by
- 2,807
- References
- 140
- Citations by year
- 2026: 184 · 2025: 170 · 2024: 143 · 2023: 159 · 2022: 168 · 2021: 165 · 2020: 197 · 2019: 168 · 2018: 161 · 2017: 174 · 2016: 152 · 2015: 156 · 2014: 130 · 2013: 130 · 2012: 129
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, non-motor symptoms, depression, constipation, pain, genitourinary dysfunction, sleep disorders, substantia nigra pars compacta, neurodegeneration, quality of life, disability
- MeSH terms
- Autonomic Nervous System Diseases, Humans, Pain, Parkinson Disease, Psychotic Disorders, Sleep Wake Disorders, Disease Progression, Pain Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
