Morphological features of MS lesions on FLAIR* at 7 T and their relation to patient characteristics
Abstract
Recently, a new MRI technique was developed at 3 Tesla (T), called fluid attenuated inversion recovery* (FLAIR*). In this study, we implemented FLAIR* in an existing MS cohort at 7 T, to investigate whether we could corroborate results of previous 7 T studies that introduced specific MS lesion characteristics. Furthermore, we aimed to investigate the meaning of these lesion characteristics by relating them to clinical characteristics of the MS patient. Three-dimensional FLAIR and T2*-weighted images of 33 MS patients and 7 healthy controls were fused into FLAIR* images. Lesion type, signal intensity and morphology were analysed on FLAIR*, side-by-side with the original FLAIR and T2*, and correlated with clinical characteristics using Spearman's rho. Three morphological features of MS lesions were visualised: (1) central vessel (CV) within lesions, present in 78 % of total MS lesions; (2) hypointense rims around MS lesions, present in eight patients; (3) FLAIR* lesions that were hypointense at T2*, present in 13 patients. The presence of hypointense (rims around) lesions was not related to clinical characteristics. The simultaneous presence of rimlike lesions and hypointense lesions within MS patients was significantly correlated (ρ = 0.52, P < 0.01). We conclude that the implementation of the new MRI technique FLAIR* at ultra-high-field 7 T combines and corroborates the results of preceding 7 T research, by showing three morphological features of MS lesions. In addition, our…
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Application of new diagnostic criteria can have an impact on future recruitment into and interpretation of clinical trials and observational studies but should not affect registration of already-approved medications.
“It was recognized that application of new diagnostic criteria can have an impact on future recruitment into and interpretation of clinical trials and observational studies 98 but should not affect registration of already-approved medications.”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [98]
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Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla
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MRI assessment of iron deposition in multiple sclerosis
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167 · see citing works
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- Authors
- Kilsdonk, I. D., Lopez-Soriano, A., Kuijer, J. P. A., de Graaf, W. L., Castelijns, J. A., Polman, C. H., Luijten, P. R., Geurts, J. J. J. G., Barkhof, F., & Wattjes, M. P.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Gemeente Amsterdam (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Kilsdonk, Iris D.
- ORCID
- Venue
- Journal of Neurology
- Published
- 2014-04-29
- Volume
- 261
- Issue
- 7
- Pages
- 1356-1364
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2013244107
- Cited by
- 55
- References
- 2
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 1 · 2014: 1
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- multiple sclerosis, MS lesions, FLAIR, 7T MRI, ultra-high field MRI, lesion morphology, hypointense lesions, T2-weighted imaging, clinical features
- MeSH terms
- Adult, Brain, Disability Evaluation, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Disease Progression
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