Cited by 154Multiple Sclerosis Research StudiesImmune responses and vaccinationsPeripheral Neuropathies and Disorders

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Vaccines and multiple sclerosis: a systematic review

Mailand, Mia Topsøe, Frederiksen, Jette Lautrup·2017·Journal of Neurology

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Abstract

Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles-mumps-rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.

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Authors: Mailand, M. T., & Frederiksen, J. L.
Affiliations: University of Copenhagen (DK)
Corresponding author: Frederiksen, Jette Lautrup
ORCID: Mailand, Mia Topsøe
Frederiksen, Jette Lautrup
Venue: Journal of Neurology
Publisher: Springer Science and Business Media LLC
Published: 2016-09-07
Volume: 264
Issue: 6
Pages: 1035-1050
ISSN: 0012-1037 (ISSN-L)
0340-5354
1432-1459
DOI: 10.1007/s00415-016-8263-4
OpenAlex: W2514636267
Cited by: 154
References: 63
Citations by year: 2026: 3 · 2025: 7 · 2024: 14 · 2023: 23 · 2022: 20 · 2021: 32 · 2020: 22 · 2019: 12 · 2018: 14 · 2017: 6 · 2016: 1
FWCI: 1.73
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Neurology (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords: multiple sclerosis, vaccines, hepatitis B vaccine, HPV vaccine, seasonal influenza vaccine, MMR vaccine, smallpox vaccine, tetanus vaccine, BCG vaccine, diphtheria vaccine, polio vaccine, multiple sclerosis risk, relapse
MeSH terms: Animals, Humans, Multiple Sclerosis, Vaccination

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Vaccines and multiple sclerosis: a systematic review

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