Strength, size and activation of knee extensors followed during 8 weeks of horizontal bed rest and the influence of a countermeasure
Abstract
Changes in the quadriceps femoris muscle with respect to anatomical cross sectional area (CSA), neural activation level and muscle strength were determined in 18 healthy men subjected to 8 weeks of horizontal bed rest (BR) with (n = 9) and without (n = 9) resistive vibration exercise (RVE). CSA of the knee extensor muscle group was measured with magnetic resonance imaging every 2 weeks during bed rest. In the control subjects (Ctrl), quadriceps femoris CSA decreased linearly over the 8 weeks of bed rest to -14.1 +/- 5.2% (P < 0.05). This reduction was significantly (P < 0.001) mitigated by the exercise paradigm (-3.5 +/- 4.2%; P < 0.05). Prior to and seven times during bed rest, maximal unilateral voluntary torque (MVT) values of the right leg were measured together with neural activation levels by means of a superimposed stimulation technique. For Ctrl, MVT decreased also linearly over time to -16.8 +/- 7.4% after 8 weeks of bed rest (P < 0.01), whereas the exercise paradigm fully maintained MVT during bed rest. In contrast to previous reports, the maximal voluntary activation remained unaltered for both groups throughout the study. For Ctrl, the absence of deterioration of the activation level might have been related to the repeated testing of muscle function during the bed rest. This notion was supported by the observation that for a subset of Ctrl subjects (n = 5) the MVT of the left leg, which was not tested during BR, was reduced by 20.5 +/- 10.1%, (P < 0.01) which was…
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Prolonged periods of bed rest result in significant atrophy of musculoskeletal mass and volume in the weight-bearing leg musculature such as the quadriceps femoris.
“Prolonged periods of bed rest result in a significant atrophy of musculoskeletal mass and volume in the weight-bearing leg musculature such as the quadriceps femoris (5–8).”
From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [5]
The study from Mulder et al. (5) was excluded due to several measurement points during bed rest that might affect the outcome measures.
“Due to several measurement points during bed rest that might affect the outcome measures, the study from Mulder et al. (5) was excluded (see discussion).”
From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [5]
Mulder et al. addressed changes in muscle size and strength during a 56-day bed rest measured at eight different time points and reported linear and equal decline in muscle strength and size.
“Interestingly, Mulder et al. (5) addressed changes in muscle size and strength during a 56-day bed rest measured at eight different time points (6 during the bed rest). They reported linear and equal decline in muscle strength and size.”
From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [5]
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Ganzkörpervibrationstherapie bei Osteoporose
Runge, M. (2011) · doi:10.1055/s-0030-1257616
“Clin Physiol 2001; 21 (3): 377–382 [12] Mulder ER, Stegeman DF, Gerrits KH et al.”
Background
- Authors
- Mulder, E. R., Stegeman, D. F., Gerrits, K. H. L., Paalman, M. I., Rittweger, J., Felsenberg, D., & de Haan, A.
- Affiliations
- Radboud University Medical Center (NL)
- Vrije Universiteit Amsterdam (NL)
- Manchester Metropolitan University (GB)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Mulder, E. R.
- Venue
- European Journal of Applied Physiology
- Published
- 2006-06-20
- Volume
- 97
- Issue
- 6
- Pages
- 706-715
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W2136185750
- Cited by
- 78
- References
- 43
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- e-space (Manchester Metropolitan University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Effects of Vibration on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- muscle atrophy, quadriceps, anatomical cross-sectional area, muscle strength, maximal voluntary torque, neuronal activation, maximal voluntary activation, countermeasures, disuse, test-retest effects
- MeSH terms
- Adult, Bed Rest, Humans, Male, Muscle Contraction, Muscular Atrophy, Vibration, Exercise, Supine Position, Weightlessness Countermeasures, Torque, Quadriceps Muscle
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