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Cited by 113Spaceflight effects on biologyTendon Structure and TreatmentMuscle Physiology and Disorders

Changes in the elastic properties of tendon structures following 20 days bed-rest in humans

Kubo, Keitaro, Akima, Hiroshi, Kouzaki, Motoki, Ito, Masamitsu, Kawakami, Yasuo, Kanehisa, Hiroaki, Fukunaga, Tetsuo·2000·European Journal of Applied Physiology
DOI 10.1007/s004210000309
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Abstract

The purpose of this study was to investigate the effects of 20 days bed-rest on the elastic properties of tendon structures of the human knee extensor muscles in vivo. Six healthy men carried out a 6 degrees head-down bed-rest for 20 days. Muscle volume and maximal voluntary contraction (MVC) torque of the quadriceps femoris muscle significantly decreased by an average of 7.8 (SD 2.7)% and 14.9 (SD 6.9)%, respectively. Before and after bed-rest, the elongation (l) of the tendon and aponeurosis of vastus lateralis muscle was measured directly by ultrasonography, while the subjects performed ramp isometric knee extension up to MVC. The extent of l tended to be greater after bed-rest. The l above 110 N was significantly greater after bed-rest. Furthermore, the mean stiffness after bed-rest [35.5 (SD 7.8) N x mm(-1)] was significantly lower than that before bed-rest [52.6 (SD 19.2) N x mm(-1)]. The rate of torque development significantly reduced after bed-rest by an average of 47%, and the bed-rest induced a lengthening in the electromechanical delay (mean 21%). These results suggest that bed-rest results in a decrease in the stiffness of tendon structures with a reduction of muscle strength and volume. These adaptations of the tendon structures to bed-rest would bring about the changes in electromechanical delay and rate of torque development.

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  • Numerically established degeneration rates for the knee extensors differed by 5% to 80% dependent on the duration of disuse.

    “Numerically established degeneration rates for the knee extensors differed by 5% to 80% dependent on the duration of disuse (6, 18, 21–23).”

    From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [6]

  • Prolonged periods of bed rest result in significant atrophy of musculoskeletal mass and volume in the weight-bearing leg musculature such as the quadriceps femoris.

    “Prolonged periods of bed rest result in a significant atrophy of musculoskeletal mass and volume in the weight-bearing leg musculature such as the quadriceps femoris (5–8).”

    From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [6]

  • This systematic review is in general agreement with the majority of other bed rest trials, which report that muscle strength is compromised to a greater extent than muscle size following bed rest.

    “Our systematic review is in general agreement with the majority of other bed rest trials, which report that muscle strength is compromised to a greater extent than muscle size following bed rest (6, 7, 10, 18, 19, 21–23, 56, 58).”

    From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [6]

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Authors
Kubo, K., Akima, H., Kouzaki, M., Ito, M., Kawakami, Y., Kanehisa, H., & Fukunaga, T.
Affiliations
The University of Tokyo (JP)
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2000-12-13
Volume
83
Issue
6
Pages
463-468
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s004210000309
OpenAlex
W2019082585
Cited by
113
References
0
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 4 · 2012: 2
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
bed rest, tendon stiffness, quadriceps, vastus lateralis, muscle atrophy, electromechanical delay, rate of torque development, head-down bed rest, muscle strength
MeSH terms
Adult, Bed Rest, Elasticity, Electromyography, Humans, Isometric Contraction, Knee, Male, Tendons, Time Factors, Ultrasonography, Muscle, Skeletal, Torque

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