CoChat
Sign Up
Cited by 78Potassium and Related DisordersCardiovascular and exercise physiologyExercise and Physiological Responses

The DOI matches its Crossref record; 262 of the 262 references it cites were found in a registry or an index.

Regulation of muscle potassium: exercise performance, fatigue and health implications

Lindinger, Michael I., Cairns, Simeon P.·2021·European Journal of Applied Physiology
DOI 10.1007/s00421-020-04546-8
Open this paper in CoChat — free account

Abstract

This review integrates from the single muscle fibre to exercising human the current understanding of the role of skeletal muscle for whole-body potassium (K+) regulation, and specifically the regulation of skeletal muscle [K+]. We describe the K+ transport proteins in skeletal muscle and how they contribute to, or modulate, K+ disturbances during exercise. Muscle and plasma K+ balance are markedly altered during and after high-intensity dynamic exercise (including sports), static contractions and ischaemia, which have implications for skeletal and cardiac muscle contractile performance. Moderate elevations of plasma and interstitial [K+] during exercise have beneficial effects on multiple physiological systems. Severe reductions of the trans-sarcolemmal K+ gradient likely contributes to muscle and whole-body fatigue, i.e. impaired exercise performance. Chronic or acute changes of arterial plasma [K+] (hyperkalaemia or hypokalaemia) have dangerous health implications for cardiac function. The current mechanisms to explain how raised extracellular [K+] impairs cardiac and skeletal muscle function are discussed, along with the latest cell physiology research explaining how calcium, β-adrenergic agonists, insulin or glucose act as clinical treatments for hyperkalaemia to protect the heart and skeletal muscle in vivo. Finally, whether these agents can also modulate K+-induced muscle fatigue are evaluated.

Overview

Integrity signals

Registry

Crossref · 10.1007/s00421-020-04546-8

Cites

262 of 262 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Items 201–262 of 262

Cited by

Sorted by citations

See all 78

Related

See all

Metadata

Authors
Lindinger, M. I., & Cairns, S. P.
Affiliations
Auckland University of Technology (NZ)
Corresponding author
Cairns, Simeon P.
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2021-01-04
Volume
121
Issue
3
Pages
721-748
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-020-04546-8
OpenAlex
W3119220887
Cited by
78
References
262
Citations by year
2026: 14 · 2025: 15 · 2024: 17 · 2023: 11 · 2022: 15 · 2021: 6
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
physical activity, muscle fatigue, hyperkalemia, hypokalemia, plasma potassium, ischemia, cardiac function, exercise performance, calcium, beta-adrenergic agonists, insulin, glucose
MeSH terms
Humans, Potassium, Exercise, Muscle, Skeletal, Muscle Fatigue

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review