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Cited by 78Potassium and Related DisordersCardiovascular and exercise physiologyExercise and Physiological Responses

The DOI matches its Crossref record; 262 of the 262 references it cites were found in a registry or an index.

Regulation of muscle potassium: exercise performance, fatigue and health implications

Lindinger, Michael I., Cairns, Simeon P.·2021·European Journal of Applied Physiology
DOI 10.1007/s00421-020-04546-8
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Abstract

This review integrates from the single muscle fibre to exercising human the current understanding of the role of skeletal muscle for whole-body potassium (K+) regulation, and specifically the regulation of skeletal muscle [K+]. We describe the K+ transport proteins in skeletal muscle and how they contribute to, or modulate, K+ disturbances during exercise. Muscle and plasma K+ balance are markedly altered during and after high-intensity dynamic exercise (including sports), static contractions and ischaemia, which have implications for skeletal and cardiac muscle contractile performance. Moderate elevations of plasma and interstitial [K+] during exercise have beneficial effects on multiple physiological systems. Severe reductions of the trans-sarcolemmal K+ gradient likely contributes to muscle and whole-body fatigue, i.e. impaired exercise performance. Chronic or acute changes of arterial plasma [K+] (hyperkalaemia or hypokalaemia) have dangerous health implications for cardiac function. The current mechanisms to explain how raised extracellular [K+] impairs cardiac and skeletal muscle function are discussed, along with the latest cell physiology research explaining how calcium, β-adrenergic agonists, insulin or glucose act as clinical treatments for hyperkalaemia to protect the heart and skeletal muscle in vivo. Finally, whether these agents can also modulate K+-induced muscle fatigue are evaluated.

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Crossref · 10.1007/s00421-020-04546-8

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Metadata

Authors
Lindinger, M. I., & Cairns, S. P.
Affiliations
Auckland University of Technology (NZ)
Corresponding author
Cairns, Simeon P.
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2021-01-04
Volume
121
Issue
3
Pages
721-748
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-020-04546-8
OpenAlex
W3119220887
Cited by
78
References
262
Citations by year
2026: 14 · 2025: 15 · 2024: 17 · 2023: 11 · 2022: 15 · 2021: 6
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
physical activity, muscle fatigue, hyperkalemia, hypokalemia, plasma potassium, ischemia, cardiac function, exercise performance, calcium, beta-adrenergic agonists, insulin, glucose
MeSH terms
Humans, Potassium, Exercise, Muscle, Skeletal, Muscle Fatigue

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