Leg-press resistance training during 20 days of 6° head-down-tilt bed rest prevents muscle deconditioning
Abstract
The purpose of this study was to investigate the effects of resistance training on the morphological and functional properties of human lower limb muscles during 20 days of 6 degrees head-down-tilt bed rest. Nine men were randomly assigned to the resistance training group (BR-Tr, n = 5) or the non-training, control group (BR-Cont, n = 4). Isometric leg-press exercises were performed: 3 s x 30 repetitions (30 s rest between repetitions) daily for 20 days during the bed-rest period. Serial axial magnetic resonance images were taken from the right thigh and leg muscles, and muscle volume, muscle length, and fibre length were estimated. The physiological cross-sectional areas (PCSAs) of the knee extensor, knee flexor, ankle plantarflexor, and ankle dorsiflexor (tibialis anterior) muscle groups were determined as muscle volume multiplied by the cosine of the angle of fibre pennation divided by fibre length. Maximum voluntary contraction (MVC) during knee extension was measured. No significant changes were observed in the PCSA of the knee extensor muscles in BR-Tr group, whereas the PCSA in the BR-Cont group decreased by 7.8%. The PCSA of the knee flexor and plantarflexor muscles in the BR-Tr group and BR-Cont group significantly decreased after bed rest (knee flexors, 10.2% and 11.5%; plantarflexors, 13.0% and 12.8%, respectively). However, in both groups bed rest had no effect on the muscle volume and PCSA of the tibialis anterior. MVC was maintained by resistance training in the…
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Numerically established degeneration rates for the knee extensors differed by 5% to 80% dependent on the duration of disuse.
“Numerically established degeneration rates for the knee extensors differed by 5% to 80% dependent on the duration of disuse (6, 18, 21–23).”
From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [22]
To ensure maximum homogeneity and test reproducibility, changes in muscle mass and size were used for m. rectus femoris, m. vastus lateralis, intermedius, and medialis.
“To ensure maximum homogeneity and test reproducibility (61) we used the changes in muscle mass and size indicated for m. rectus femoris, the m. vastus lateralis, intermedius, and medialis (22, 62).”
From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [22]
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- Authors
- Akima, H., Kubo, K., Kanehisa, H., Suzuki, Y., Gunji, A., & Fukunaga, T.
- Affiliations
- The University of Tokyo (JP)
- Venue
- European Journal of Applied Physiology
- Published
- 2000-05-15
- Volume
- 82
- Issue
- 1-2
- Pages
- 30-38
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W2065673675
- Cited by
- 115
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 5
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- resistance training, bed rest, muscle deconditioning, muscle atrophy, leg press, isometric exercise, lower limb muscles, knee extensors, knee flexors, plantar flexors, tibialis anterior, muscle volume, physiological cross-sectional area, muscle strength, microgravity
- MeSH terms
- Adult, Bed Rest, Biomechanical Phenomena, Humans, Isometric Contraction, Leg, Male, Exercise, Head-Down Tilt, Muscle, Skeletal
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