CATs and HATs: the SLC7 family of amino acid transporters

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

Ishimoto, T., Nagano, O., Yae, T., Tamada, M., Motohara, T., Oshima, H., Oshima, M., Ikeda, T., Asaba, R., Yagi, H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.038 · Cited by 1,192

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M., & Cantrell, D. A. (2013) · Nature Immunology · doi:10.1038/ni.2556 · Cited by 930

Arginine Metabolism Revisited

Morris, S. M. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.226621 · Cited by 435

The x cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

Lo, M., Wang, Y., & Gout, P. W. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21366 · Cited by 399

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

Yan, R., Zhao, X., Lei, J., & Zhou, Q. (2019) · Nature · doi:10.1038/s41586-019-1011-z · Cited by 358

Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10

Friesema, E. C. H., Jansen, J., Jachtenberg, J.-W., Visser, W. E., Kester, M. H. A., & Visser, T. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0112 · Cited by 285

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

Parker, J. L., Deme, J. C., Kolokouris, D., Kuteyi, G., Biggin, P. C., Lea, S. M., & Newstead, S. (2021) · Nature Communications · doi:10.1038/s41467-021-27414-1 · Cited by 272

CD98hc (SLC3A2) mediates integrin signaling

Feral, C. C., Nishiya, N., Fenczik, C. A., Stuhlmann, H., Slepak, M., & Ginsberg, M. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404852102 · Cited by 264

Thinking Outside the Cleft to Understand Synaptic Activity: Contribution of the Cystine-Glutamate Antiporter (System xc−) to Normal and Pathological Glutamatergic Signaling

Bridges, R., Lutgen, V., Lobner, D., & Baker, D. A. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003889 · Cited by 205

Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

Rosario, F. J., Kanai, Y., Powell, T. L., & Jansson, T. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238014 · Cited by 185

Thyroid hormone transporters in health and disease

Jansen, J., Friesema, E. C. H., Milici, C., & Visser, T. J. (2005) · Thyroid · doi:10.1089/thy.2005.15.757 · Cited by 181

The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine

Guan, J., Lo, M., Dockery, P., Mahon, S., Karp, C. M., Buckley, A. R., Lam, S., Gout, P. W., & Wang, Y.-Z. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0894-4 · Cited by 134

Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise

Drummond, M. J., Fry, C. S., Glynn, E. L., Timmerman, K. L., Dickinson, J. M., Walker, D. K., Gundermann, D. M., Volpi, E., & Rasmussen, B. B. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01408.2010 · Cited by 120

Specific PET imaging of xC- transporter activity using a 18F-labeled glutamate derivative reveals a dominant pathway in tumor metabolism

Koglin, N., Mueller, A., Berndt, M., Schmitt-Willich, H., Toschi, L., Stephens, A. W., Gekeler, V., Friebe, M., & Dinkelborg, L. M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0687 · Cited by 120

Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link

Hanswijk, S. I., Spoelder, M., Shan, L., Verheij, M. M. M., Muilwijk, O. G., Li, W., Liu, C., Kolk, S. M., & Homberg, J. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165850 · Cited by 86

Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes

Baird, F. E., Bett, K. J., MacLean, C., Tee, A. R., Hundal, H. S., & Taylor, P. M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2009 · Cited by 83

Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice

Zhou, Y., Waanders, L. F., Holmseth, S., Guo, C., Berger, U. V., Li, Y., Lehre, A.-C., Lehre, K. P., & Danbolt, N. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529065 · Cited by 49

Thyroid hormone transport across L-type amino acid transporters: what can molecular modelling tell us?

Krause, G., & Hinz, K. M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.018 · Cited by 27

Cryo-EM structure of the human Asc-1 transporter complex

Li, Y., Guo, Y., Bröer, A., Dai, L., Brӧer, S., & Yan, R. (2024) · Nature Communications · doi:10.1038/s41467-024-47468-1 · Cited by 12

Dual Role of Dysfunctional Asc-1 Transporter in Distinct Human Pathologies, Human Startle Disease, and Developmental Delay

Drehmann, P., Milanos, S., Schaefer, N., Kasaragod, V. B., Herterich, S., Holzbach-Eberle, U., Harvey, R. J., & Villmann, C. (2023) · eneuro · doi:10.1523/eneuro.0263-23.2023 · Cited by 9

A new metabolic disorder in human cationic amino acid transporter‐2 that mimics arginase 1 deficiency in newborn screening

Yahyaoui, R., Blasco‐Alonso, J., Benito, C., Rodríguez‐García, E., Andrade, F., Aldámiz‐Echevarría, L., Muñoz‐Hernández, M. C., Vega, A. I., Pérez‐Cerdá, C., García‐Martín, M. L., et al. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12063 · Cited by 7