Cited by 251Epilepsy research and treatmentTactile and Sensory InteractionsPsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Functional neuroanatomy of the insular lobe

Open access

Stephani, C., Fernandez-Baca Vaca, G., Maciunas, R., Koubeissi, M., Lüders, H. O.·2011·Brain Structure and Function

DOI 10.1007/s00429-010-0296-3PMC PMC3097350

Open this paper in CoChat — free account Open PDF

Abstract

The insula is the fifth lobe of the brain and it is the least known. Hidden under the temporal, frontal and parietal opercula, as well as under dense arterial and venous vessels, its accessibility is particularly restricted. Functional data on this region in humans, therefore, are scarce and the existing evidence makes conclusions on its functional and somatotopic organization difficult. 5 patients with intractable epilepsy underwent an invasive presurgical evaluation with implantation of diagnostic invasive-depth electrodes, including insular electrodes that were inserted using a mesiocaudodorsal to laterorostroventral approach. Altogether 113 contacts were found to be in the insula and were stimulated with alternating currents during preoperative monitoring. Different viscerosensitive and somatosensory phenomena were elicited by stimulation of these electrodes. A relatively high density of electrode contacts enabled us to delineate several functionally distinct areas within the insula. We found somatosensory symptoms to be restricted to the posterior insula and a subgroup of warmth or painful sensations in the dorsal posterior insula. Viscerosensory symptoms were elicited by more anterior electrode contacts with a subgroup of gustatory symptoms occurring after stimulation of electrode contacts in the central part of the insula. The anterior insula did not show reproducible responses to stimulation. In line with previous studies, we found evidence for somato- and viscerosensory cortex in the insula. In addition, our results suggest that there is a predominantly posterior and central distribution of these functions in the insular lobe.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00429-010-0296-3

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 3×
“Results of these and other studies and considerations concerning the neuroanatomy of the insula have led to a hypothesis regarding a central role of the insula for higher cortical functions and processing of homeostatic information (Singer et al. 2004; Craig 2009).”
BackgroundResult
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
A specific neural substrate for perceiving facial expressions of disgust
Phillips, M. L., Young, A. W., Senior, C., Brammer, M., Andrew, C., Calder, A. J., Bullmore, E. T., Perrett, D. I., Rowland, D., Williams, S. C. R., et al. (1997) · Nature · doi:10.1038/39051 · Cited by 1,609
The Cerebral Cortex of Man
Penfield, W. G. (1950) · Digital Commons - RU (Rockefeller University) · Cited by 1,387
A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis
Kurth, F., Zilles, K., Fox, P. T., Laird, A. R., & Eickhoff, S. B. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0255-z · Cited by 1,293
Damage to the insula disrupts addiction to cigarette smoking
Naqvi, N. H., Rudrauf, D., Damasio, H., & Bechara, A. (2007) · Science · doi:10.1126/science.1135926 · Cited by 1,245
Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen
Economo, C. V., & Koskinas, G. N. (1925) · Springer eBooks · Cited by 1,234
The Cerebral Cortex of Man: A Clinical Study of Localization of Function
(1968) · JAMA · doi:10.1001/jama.1968.03150020096041 · Cited by 1,218
Insula of the old world monkey. III: Efferent cortical output and comments on function
Mesulam, M. ‐., & Mufson, E. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902120104 · Cited by 1,013

Flagged first, then by citations

Show all 69 references

Research works printed but not linked: 4

Brodmann K (1909) Vergleichende Lokalisationslehre der Großhirnrinde des Menschen. Barth JA, Leipzig
Reil JC (1809) Die sylvische Grube. Arch Physiol 9:195–208
Rose M (1928) Die Inselrinde des Menschen und der Tiere. J Psychol Neurol 37:467–624
Vogt C, Vogt O (1919) Allgemeine Ergebnisse unserer Hirnforschung. J Psychol Neurol 25:279–461

Sorted by citations

Items 101–200 of 251

Homotopic reciprocal functional connectivity between anterior human insulae
Lacuey, N., Zonjy, B., Kahriman, E. S., Marashly, A., Miller, J., Lhatoo, S. D., & Lüders, H. O. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1065-0 · Cited by 23
Subjective states induced by intracranial electrical stimulation matches the cytoarchitectonic organization of the human insula
Duong, A., Quabs, J., Kucyi, A., Lusk, Z., Buch, V., Caspers, S., & Parvizi, J. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.11.001 · Cited by 21
Localization of the primary taste cortex by contrasting passive and attentive conditions
Nakamura, Y., Tokumori, K., Tanabe, H. C., Yoshiura, T., Kobayashi, K., Nakamura, Y., Honda, H., Yoshiura, K., & Goto, T. K. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3499-z · Cited by 22
Sex Differences in Insular Cortex Gyri Responses to the Valsalva Maneuver
Macey, P. M., Rieken, N. S., Kumar, R., Ogren, J. A., Middlekauff, H. R., Wu, P., Woo, M. A., & Harper, R. M. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00087 · Cited by 20
The Insula: A Stimulating Island of the Brain
Rachidi, I., Minotti, L., Martin, G., Hoffmann, D., Bastin, J., Olivier David, A., & Kahane, P. (2021) · Brain Sciences · doi:10.3390/brainsci11111533 · Cited by 20
Descending pain modulatory efficiency in healthy subjects is related to structure and resting connectivity of brain regions
Huynh, V., Lütolf, R., Rosner, J., Luechinger, R., Curt, A., Kollias, S., Michels, L., & Hubli, M. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118742 · Cited by 18
Visceral and emotional responses to direct electrical stimulations of the cortex
Soulier, H., Mauguı̀ere, F., Catenoix, H., Montavont, A., Isnard, J., Hermier, M., Guénot, M., Rheims, S., & Mazzola, L. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51694 · Cited by 21
The pathoconnectivity network analysis of the insular cortex: A morphometric fingerprinting
Nani, A., Manuello, J., Mancuso, L., Liloia, D., Costa, T., Vercelli, A., Duca, S., & Cauda, F. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117481 · Cited by 19
Seizure semiology, localization, and the 2017 ILAE seizure classification
Turek, G., & Skjei, K. L. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108455 · Cited by 19
70 Years of Human Cingulate Cortex Stimulation. Functions and Dysfunctions Through the Lens of Electrical Stimulation
Pelliccia, V., Vecchio, M. D., Avanzini, P., Revay, M., Sartori, I., & Caruana, F. (2022) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000961 · Cited by 20
Just add water: Effects of added gastric distention by water on gastric emptying and satiety related brain activity
Camps, G., Veit, R., Mars, M., de Graaf, C., & Smeets, P. A. M. (2018) · Appetite · doi:10.1016/j.appet.2018.04.023 · Cited by 19
The impact of age-related hearing loss on structural neuroanatomy: A meta-analysis
Slade, K., Reilly, J. H., Jablonska, K., Smith, E., Hayes, L. D., Plack, C. J., & Nuttall, H. E. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.950997 · Cited by 23
Sustained Spatial Attention to Vibrotactile Stimulation in the Flutter Range: Relevant Brain Regions and Their Interaction
Goltz, D., Pleger, B., Thiel, S. D., Villringer, A., & Müller, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084196 · Cited by 18
Anatomical variations of the insular gyri: A morphological study and proposal of unified classification
Wysiadecki, G., Małkiewicz, A., Rózniecki, J., Polguj, M., Haładaj, R., Żytkowski, A., & Topol, M. (2018) · Clinical Anatomy · doi:10.1002/ca.23060 · Cited by 18
Clinical topography relationship in patients with parenchymal neurocysticercosis and seizures
Duque, K. R., Escalaya, A. L., Zapata, W. R., Burneo, J. G., Bustos, J. A., Gonzáles, I., Saavedra, H., Pretell, E. J., & Garcia, H. H. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.06.011 · Cited by 18
Electrical stimulation of the insulo-opercular region: visual phenomena and altered body-ownership symptoms
Yu, K., Yu, T., Qiao, L., Liu, C., Wang, X., Zhou, X., Ni, D., Zhang, G., & Li, Y. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.09.014 · Cited by 22
Decreased self-reported appetite following insular cortex resection in patients with epilepsy
Hébert-Seropian, B., Boucher, O., Citherlet, D., Roy-Côté, F., Gravel, V., Obaïd, S., Bouthillier, A., & Nguyen, D. K. (2021) · Appetite · doi:10.1016/j.appet.2021.105479 · Cited by 17
Distinct Insular Functional Connectivity Changes Related to Mood and Fatigue Improvements in Major Depressive Disorder Following Tai Chi Training: A Pilot Study
Xu, A., Zimmerman, C. S., Lazar, S. W., Ma, Y., Kerr, C. E., & Yeung, A. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2020.00025 · Cited by 16
Does unilateral insular resection disturb personality? A study with epileptic patients
Hébert-Seropian, B., Boucher, O., Sénéchal, C., Rouleau, I., Bouthillier, A., Leporé, F., & Nguyen, D. K. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.04.001 · Cited by 16
Bipolar electro-coagulation with cortextomy in the treatment of insular and insulo-opercular epilepsy explored by stereoelectro-encephalography
Ding, H., Zhou, J., Guan, Y., Zhai, F., Wang, M., Wang, J., & Luang, G. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.05.007 · Cited by 16
Influence of hemispheric white matter lesions and migraine characteristics on cortical thickness and volume
Komáromy, H., He, M., Perlaki, G., Orsi, G., Nagy, S. A., Bosnyák, E., Olayinka, D. K., John, F., Trauninger, A., & Pfund, Z. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-0959-2 · Cited by 18
Electrostimulation of the white matter of the posterior insula and medial operculum: perception of vibrations, heat, and pain
Mandonnet, V., Obaïd, S., Descoteaux, M., St‐Onge, E., Devaux, B. C., Levé, C., Froelich, S. C., Rheault, F., & Mandonnet, E. (2023) · Pain · doi:10.1097/j.pain.0000000000003069 · Cited by 14
Nonconvulsive Status Epilepticus in Acute Intracerebral Hemorrhage
Matsubara, S., Sato, S., Kodama, T., Egawa, S., Nakamoto, H., Toyoda, Ḱ., & Kubota, Y. (2018) · Stroke · doi:10.1161/strokeaha.118.021414 · Cited by 15
Brain activation during the expectations of sensory experience for cutaneous electrical stimulation
Jung, W.-M., Ryu, Y., Park, H., Lee, H., & Chae, Y. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.06.022 · Cited by 15
Navigating the Island of Reil: how to understand the insular cortex
Wynford‐Thomas, R., & Powell, R. (2016) · Practical Neurology · doi:10.1136/practneurol-2016-001493 · Cited by 15
Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal
Sabat, M., de Dampierre, C., & Tallon‐Baudry, C. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2413808122 · Cited by 20
An exploratory study of the relationship between postoperative nausea and vomiting and postdischarge nausea and vomiting in children undergoing ambulatory surgery
Chandrakantan, A., Reinsel, R. A., Jasiewicz, R., Jacob, Z., & Seidman, P. A. (2019) · Pediatric Anesthesia · doi:10.1111/pan.13612 · Cited by 14
Upward gaze and head deviation with frontal eye field stimulation
Kaiboriboon, K., Lüders, H. O., Miller, J. P., & Leigh, R. J. (2012) · Epileptic Disorders · doi:10.1684/epd.2012.0494 · Cited by 14
Anatomically related gray and white matter alterations in the brains of functional dyspepsia patients
Nan, J., Liu, J., Mu, J., Zhang, Y., Zhang, M., Tian, J., Liang, F., & Zeng, F. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12560 · Cited by 14
The Fundamental Basis of Palpitations: A Neurocardiology Approach
Kandiah, J. W., Blumberger, D. M., & Rabkin, S. W. (2021) · Current Cardiology Reviews · doi:10.2174/1573403x17666210909123930 · Cited by 14
Hypercognitive seizures − Proposal of a new term for the phenomenon forced thinking in epilepsy
Stephani, C., & Koubeissi, M. Z. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.02.013 · Cited by 12
Effects of three needling manipulations of the right-side Zusanli (ST 36) on brain using functional magnetic resonance imaging
Fengyan, L., Junhong, G., Wang, Y., Qiufu, D., Yan, B., Yang, H., Guolei, Z., Juanjuan, X., Yuxue, Z., Wu, S.-Y., et al. (2017) · 中医杂志：英文版 · doi:10.1016/s0254-6272(17)30064-x · Cited by 13
Superficial anatomy of the neonatal cerebrum — an ultrasonographic roadmap
Gonçalves, F. G., & Hwang, M. (2020) · Pediatric Radiology · doi:10.1007/s00247-020-04794-y · Cited by 13
Recovery of empathetic function following resection of insular gliomas
Wang, X., Gu, X., Fan, J., Wang, S., Fu, Z., Hof, P. R., Liu, P., & Gao, Z. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1380-y · Cited by 13
Cortical thickness changes in adult moyamoya disease assessed by structural magnetic resonance imaging
Qiao, P., Zuo, Z., Han, C., Zhou, J., Zhang, H., Duan, L., Qian, T., & Li, G. (2017) · Clinical Imaging · doi:10.1016/j.clinimag.2017.07.005 · Cited by 13
The Functional Network Processing Acute Electrical Itch Stimuli in Humans
Mochizuki, H., Hernandez, L. E. D. L. C., Yosipovitch, G., Sadato, N., & Kakigi, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00555 · Cited by 14
Resting-State Functional Connectivity Profile of Insular Subregions
Ghaziri, J., Fei, P., Tucholka, A., Obaïd, S., Boucher, O., Rouleau, I., & Nguyen, D. K. (2024) · Brain Sciences · doi:10.3390/brainsci14080742 · Cited by 13
Vascular feature as a modulator of the aging brain
Li, H., Jiang, S., Dong, D., Hu, J. H., He, C. H., Hou, C., He, H., Huang, H., Shen, D., Pei, H., et al. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac039 · Cited by 12
Responses of Chemosensory Perception to Stimulation of the Human Brain
Li, Y., Tan, Z., Wang, J., Cai, Y., Wang, M., Zhou, W., & Wang, L. (2022) · Annals of Neurology · doi:10.1002/ana.26532 · Cited by 11
Differences of Intracranial Electrical Stimulation Thresholds in the Human Brain
Stephani, C., & Koubeissi, M. Z. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.02.011 · Cited by 11
The role of the insular cortex in the control of visceral functions
Александров, В. Г., & Aleksandrova, N. P. (2015) · Human Physiology · doi:10.1134/s0362119715050023 · Cited by 11
What does brain imaging tell us about itch?
Mochizuki, H., Hernandez, L. E. D. L. C., & Yosipovitch, G. (2019) · Itch · doi:10.1097/itx.0000000000000023 · Cited by 11
Epilepsy surgery
Kunieda, T., Kikuchi, T., & Miyamoto, S. (2012) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32835774d4 · Cited by 11
Las raíces del miedo: Euskadi, una sociedad atemorizada
Iribarren, F. D. (2003) · Dialnet (Universidad de la Rioja) · Cited by 11
The Role of the Insular Cortex and Serotonergic System in the Modulation of Long-Lasting Nociception
Coffeen, U., Ramírez-Rodríguez, G. B., Simón‐Arceo, K., Mercado, F., Almanza, A., Jaimes, O., Parra-Vitela, D., Vázquez-Barreto, M., & Pellicer, F. (2024) · Cells · doi:10.3390/cells13201718 · Cited by 11
Brain structural changes in regions within the salience network in patients with functional constipation
Jia, Z., Li, G., Hu, Y., Li, H., Zhang, W., Wang, J., Zhang, L., Tan, Z., Lv, S., von Deneen, K. M., et al. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00648-3 · Cited by 11
Mild Inflammation in Healthy Males Induces Fatigue Mediated by Changes in Effective Connectivity Within the Insula
Stefanov, K., McLean, J., McColl, A., Basu, N., Cavanagh, J., & Krishnadas, R. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.04.005 · Cited by 10
Somatosensory Auras in Epilepsy: A Narrative Review of the Literature
Caprara, A. L. F., Ali, H. T., Elrefaey, A., Elejla, S. A., & Rissardo, J. P. (2023) · Medicines · doi:10.3390/medicines10080049 · Cited by 10
The Mysterious Island: Insula and Its Dual Function in Sleep and Wakefulness
Levichkina, E. V., Busygina, I. I., Pigareva, M. L., & Pigarev, I. N. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.592660 · Cited by 9
The role of lateralisation and sex on insular cortex: 3D volumetric analysis
ÖZ, F., Acer, N., Katayıfçı, N., Aytaç, G., Karaali̇, K., & Sındel, M. (2021) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-2010-137 · Cited by 9
Partial Amelioration of Medial Visceromotor Network Dysfunction in Major Depression by Sertraline
Schafer, S. M., Wager, T. D., Mercado, R., Thayer, J. F., Allen, J. J. B., & Lane, R. D. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000200 · Cited by 11
Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula
Kwon, M., Bo, K., Botvinik‐Nezer, R., Kragel, P. A., Oudenhove, L. V., Wager, T. D., Ashar, Y. K., Atlas, L. Y., Barrett, L. F., Becker, B., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71568-9 · Cited by 10
Anterior Versus Posterior Insular Epilepsy: Correlations with Semiology Based on Stereoelectroencephalography
Chisholm, J., Krishnan, B., Khoury, J., Alexopoulos, A. V., Bingaman, W. E., Serletis, D., Najm, I., & Bulacio, J. C. (2025) · Annals of Neurology · doi:10.1002/ana.70015 · Cited by 8
Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics
Billaux, P., Maurage, P., Cabé, N., Lanièpce, A., Segobin, S. H., & Pitel, A. (2023) · Addiction Biology · doi:10.1111/adb.13324 · Cited by 8
Reproducibility of Neurochemical Profile Quantification in Pregenual Cingulate, Anterior Midcingulate, and Bilateral Posterior Insular Subdivisions Measured at 3 Tesla
de Matos, N. M. P., Meier, L., Wyss, M., Meier, D., Gutzeit, A., Ettlin, D. A., & Brügger, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00300 · Cited by 8
The localizing value of epileptic auras: pitfalls in semiology and involved networks
Russo, A., Arbune, A.-A., Bansal, L. R., Mindruta, I., Gobbi, G., & DUCHOWNY, M. S. (2019) · Epileptic Disorders · doi:10.1684/epd.2019.1106 · Cited by 8
A Transmissive Theory of Brain Function: Implications for Health, Disease, and Consciousness
Rouleau, N., & Cimino, N. (2022) · NeuroSci · doi:10.3390/neurosci3030032 · Cited by 8
Neural control of fundamental frequency rise and fall in Mandarin tones
Howell, P., Jiang, J., Peng, D., & Lu, C. (2012) · Brain and Language · doi:10.1016/j.bandl.2012.01.004 · Cited by 8
Separating the Idea from the Action: A sLORETA Study
Rakuša, M., Busan, P., Battaglini, P. P., & Zidar, J. (2017) · Brain Topography · doi:10.1007/s10548-017-0584-9 · Cited by 8
Mapping Brain Activity in Response to Taste Stimulation
Small, D. M., & Faurion, A. (2015) · Wiley eBooks · doi:10.1002/9781118971758.ch35 · Cited by 8
The Seeking Proxies for Internal States (SPIS) Model of OCD – A Comprehensive Review of Current Findings and Implications for Future Directions
Lazarov, A., Liberman, N., & Dar, R. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230920165403 · Cited by 6
Topographical map of subjective states evoked by focal seizures and electrical stimulation of the human insula
Duong, A., Daliri, A., Montavont, A., Stein, E. L. V., van Staalduinen, E. K., Pantis, S., Guénot, M., Rheims, S., Buch, V., Mazzola, L., et al. (2025) · Epilepsia · doi:10.1111/epi.18433 · Cited by 6
Déjà‐vu evoked by electrical stimulation of the insula
Toffa, D. H., Assi, E. B., Pépin, C., Martineau, L., Robert, M., Bouthillier, A., & Nguyen, D. K. (2022) · Epileptic Disorders · doi:10.1684/epd.2022.1433 · Cited by 6
Newborn insula gray matter volume is prospectively associated with early life adiposity gain
Rasmussen, J. M., Entringer, S., Kruggel, F., Cooper, D. M., Styner, M. A., Gilmore, J. H., Potkin, S. G., Wadhwa, P. D., & Buß, C. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.114 · Cited by 6
Smell Regions in Patients with Vitamin D Deficiency: An MRI Evaluation
Şencan, Z., Muluk, N. B., & Şahan, M. H. (2021) · Journal of Neurological Surgery Part B Skull Base · doi:10.1055/s-0040-1722227 · Cited by 6
Somatovisceral Convergence in Sleep-Wake Cycle: Transmitting Different Types of Information via the Same Pathway
Levichkina, E. V., Pigareva, M. L., Limanskaya, A. V., & Pigarev, I. N. (2022) · Frontiers in Network Physiology · doi:10.3389/fnetp.2022.840565 · Cited by 6
Enacting Happiness from Emotions and Moods
Laurent, É., Bague, K., Vegas, C., & Dartevelle, J. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.106954 · Cited by 5
The impact of crossmodal predictions on the neural processing of aesthetic stimuli
Tiihonen, M., Haumann, N. T., Юрьевич, Ш. Ю., Vuust, P., Jacobsen, T., & Brattico, E. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0418 · Cited by 6
Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings
Citherlet, D., Boucher, O., Robert, M., Provost, C., Alcindor, A., Peng, K., Beaumont, L. D., & Nguyen, D. K. (2025) · Brain Sciences · doi:10.3390/brainsci15070680 · Cited by 5
Refractory Nausea and Vomiting Due to Central Nervous System Injury: A Focused Review
Stoica, S., Hogge, C. J., & Theeler, B. J. (2025) · Life · doi:10.3390/life15071021 · Cited by 6
The role of the insula in the Takotsubo Cardiomyopathy: a scoping review.
Catalano, L., Sagliano, L., Salzillo, A., Ivanova, E., Pennacchio, M., Mancano, M., Papagno, C., & Trojano, L. (2025) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106369 · Cited by 4
Microsurgical preservation of lenticulostriate artery perforators in insular glioma: the two point antegrade skeletonization technique
Das, K. K., Rai, S., Katyayan, I., Madheshiya, S., Srivastava, A. K., & Jaiswal, A. K. (2025) · Acta Neurochirurgica · doi:10.1007/s00701-025-06422-w · Cited by 4
The Impact of Alpha‐Neurofeedback Training on Gastric Slow Wave Activity and Heart Rate Variability in Humans
Mathew, J., Galacgac, J., Smith, M. L., Du, P., & Çakmak, Y. Ö. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.15009 · Cited by 4
The Insular Cortex
Richardson, J. D., & Fridriksson, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-407794-2.00010-9 · Cited by 4
Brain Processing of CT-Targeted Stimulation
Björnsdotter, M. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6418-5_11 · Cited by 4
Die funktionelle Neuroanatomie des limbischen Systems
Dicke, U. (2020) · Springer eBooks · doi:10.1007/978-3-662-59038-6_2 · Cited by 4
Insular Cortical circuits
Ibrahim, C., & Foll, B. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823453-2.00005-9 · Cited by 4
Let’s focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders
Billaux, P., Segobin, S. H., Maillard, A., Bloch, V., Delmaire, C., Cabé, N., Lanièpce, A., Maurage, P., Poireau, M., Emmanuelle Volle, C., et al. (2024) · European Psychiatry · doi:10.1192/j.eurpsy.2024.1784 · Cited by 3
Electroclinical characteristics of posterior lateral temporal epilepsy
Wang, F., Liu, X., Pan, S., Wang, M., & Chen, S. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.09.036 · Cited by 3
Mifepristone reduces hypothalamo-pituitary-adrenal axis activation and restores weight loss in rats subjected to dietary restriction and methylphenidate administration
Khalil, R. B., Smayra, V., Saliba, Y., Hajal, J., Bakhos, J., Souaiby, L., Richa, S., Tamraz, J. C., & Farès, N. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.12.008 · Cited by 3
Beyond belongingness: Rethinking innate behavioral predispositions, learning constraints, and cognitive capacities
Sosa, R. (2022) · Adaptive Behavior · doi:10.1177/10597123221097451 · Cited by 5
Knowledge Atlas of Insular Epilepsy: A Bibliometric Analysis
Li, M., Ma, X., Mai, C., Fan, Z., Wang, Y., & Ren, Y. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s392953 · Cited by 3
Atypical Hierarchical Connectivity Revealed by Stepwise Functional Connectivity in Aging
Li, H., Shi, H., Jiang, S., Hou, C., Wu, H., Yao, G., Yao, D., & Luo, C. (2023) · Bioengineering · doi:10.3390/bioengineering10101166 · Cited by 3
Insular Gliomas. Experience in a Latin American Center and Assessment of Variables Related to Surgical Management and Prognosis
Ruella, M. E., Caffaratti, G., Villamil, F., Crivelli, L., & Cervio, A. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.09.019 · Cited by 3
Measurements of the Insula Volume Using MRI
Acer, N., & Turgut, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-75468-0_10 · Cited by 3
Somatosensory and Pharyngolaryngeal Auras in Temporal Lobe Epilepsy Surgeries
Weil, A. G., Surbeck, W., Rahme, R., Bouthillier, A., Harroud, A., & Nguyen, D. K. (2013) · ISRN Neurology · doi:10.1155/2013/148519 · Cited by 3
Isolated Left Insular Infarction and Acute Psychosis: A Misleading Clinical Presentation
Assogba, K. (2018) · Archives in Neurology & Neuroscience · doi:10.33552/ann.2018.02.000531 · Cited by 2
Functional neurosurgery. The modulation of neural and mind circuits
Alotaibi, F., & Alkhairallah, T. S. (2012) · Neurosciences · doi:10.17712/1658-3183.1912 · Cited by 2
The Isle of Craig: Neuroanatomical and Functional Evidence for a Role of the Insular Cortex in Subjective Feelings
Evrard, H. (2025) · Current topics in behavioral neurosciences · doi:10.1007/7854_2025_590 · Cited by 2
The association between fronto-insular interaction and executive function during childhood and adolescence in a resting state fMRI study
Kim, J., Kim, N., Kim, Y., Park, B., & Park, M. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-14736-z · Cited by 2
Clinical, structural and functional features of paroxismal syndrome in insular and temporal lobe tumors
Khachatryan, R. G., Bart, V. A., Maslova, L. N., Фадеева, Т., Sebelev, K. I., Tastanbekov, M. M., Alekseeva, T. M., & Khachatryan, V. A. (2020) · Burdenko s Journal of Neurosurgery · doi:10.17116/neiro20208404136 · Cited by 2
Ecstatic Epileptic Seizures - the Role of the Insula in Altered Self-Awareness
Gschwind, M., & Picard, F. (2014) · Cited by 2
Clinical features of temporal lobe epilepsy with involvement of the insular lobe
Гургеновна, Х. Р., Alekseeva, T. M., Khachatryan, W. А., Sebelev, K. I., & Петровна, А. Н. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20211210617 · Cited by 2
The Functional Neuroanatomy of the Limbic System
Dicke, U. (2023) · Springer eBooks · doi:10.1007/978-3-662-65774-4_2 · Cited by 2
Commentary: There is no such thing as interoception
Murphy, J. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1579066 · Cited by 2
Neuropsychologie des instincts et des émotions
Gil, R. (2024) · Elsevier eBooks · doi:10.1016/b978-2-294-78570-2.00018-6 · Cited by 1
Associations Between Trail-Making Test Black and White Performance and Gray Matter Volume in Community-Dwelling Cognitively Healthy Adults Aged 40 to 80 Years
Simfukwe, C., An, S. S. A., & Youn, Y. C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124041 · Cited by 1
Abnormal connection between the posterior insula and the gastric network among patients with functional constipation
Zha, D., Chen, J., Yang, Y., Zhang, L., Tao, S., Wang, W., & Li, M. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1624489 · Cited by 1
Comparative insights into insula structure and function
Charbonneau, J. A., Carp, S. B., Bennett, J. L., Maw, S. M., Moadab, G., Christianson, J. P., Baxter, M. G., & Bliss‐Moreau, E. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02380-3 · Cited by 1
Role of the Insula in Human Cognition and Motivation
DIVITIIS, O. D., Somma, T., D’Urso, G., Turgut, M., & Cappabianca, P. (2018) · Springer eBooks · doi:10.1007/978-3-319-75468-0_15 · Cited by 1

Authors: Stephani, C., Fernandez-Baca Vaca, G., Maciunas, R., Koubeissi, M., & Lüders, H. O.
Affiliations: University Hospitals Cleveland Medical Center (US)
Corresponding author: Stephani, C.
ORCID: Stephani, C.
Koubeissi, M.
Venue: Brain Structure and Function
Publisher: Springer Science and Business Media LLC
Published: 2010-12-14
Volume: 216
Issue: 2
Pages: 137-149
ISSN: 1863-2653 (ISSN-L)
1863-2661
DOI: 10.1007/s00429-010-0296-3
PMC: PMC3097350
OpenAlex: W2167344375
Cited by: 251
References: 69
Citations by year: 2026: 8 · 2025: 20 · 2024: 12 · 2023: 17 · 2022: 18 · 2021: 20 · 2020: 14 · 2019: 18 · 2018: 26 · 2017: 21 · 2016: 17 · 2015: 19 · 2014: 10 · 2013: 11 · 2012: 13
FWCI: 6.12
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Brain Structure and Function (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: insula, functional neuroanatomy, somatosensory cortex, gustatory cortex, insular lobe, drug-resistant epilepsy, preoperative assessment, electrical stimulation, somatotopic organization, depth electrodes
MeSH terms: Adult, Analysis of Variance, Brain Mapping, Cerebral Cortex, Electrodes, Implanted, Electroencephalography, Epilepsy, Female, Humans, Sensation, Deep Brain Stimulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional neuroanatomy of the insular lobe

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks