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Quantitative in vivo MRI measurement of cortical development in the fetus
Abstract
Normal brain development is associated with expansion and folding of the cerebral cortex following a highly orchestrated sequence of gyral-sulcal formation. Although several studies have described the evolution of cerebral cortical development ex vivo or ex utero, to date, very few studies have characterized and quantified the gyrification process for the in vivo fetal brain. Recent advances in fetal magnetic resonance imaging and post-processing computational methods are providing new insights into fetal brain maturation in vivo. In this study, we investigate the in vivo fetal cortical folding pattern in healthy fetuses between 25 and 35 weeks gestational age using 3-D reconstructed fetal cortical surfaces. We describe the in vivo fetal gyrification process using a robust feature extraction algorithm applied directly on the cortical surface, providing an explicit delineation of the sulcal pattern during fetal brain development. We also delineate cortical surface measures, including surface area and gyrification index. Our data support an exuberant third trimester gyrification process and suggest a non-linear evolution of sulcal development. The availability of normative indices of cerebral cortical developing in the living fetus may provide critical insights on the timing and progression of impaired cerebral development in the high-risk fetus.
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“A study of healthy fetuses at 25–35 GW shows an exuberant third-trimester gyrification process and suggests a non-linear evolution of sulcal development [53].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [53]
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Metadata
- Authors
- Clouchoux, C., Kudelski, D., Gholipour, A., Warfield, S. K., Viseur, S., Bouyssi-Kobar, M., Mari, J.-L., Evans, A. C., du Plessis, A. J., & Limperopoulos, C.
- Affiliations
- Children's National (US)
- Centre National de la Recherche Scientifique (FR)
- Boston Children's Hospital (US)
- Université de Provence Aix-Marseille I (FR)
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Limperopoulos, Catherine
- ORCID
- Venue
- Brain Structure and Function
- Published
- 2011-05-12
- Volume
- 217
- Issue
- 1
- Pages
- 127-139
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2051630621
- Cited by
- 164
- References
- 62
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 15 · 2021: 23 · 2020: 14 · 2019: 12 · 2018: 14 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Canadian Institutes of Health Research (81116_1)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- fetal brain development, cerebral cortex, cortical folding, fetal MRI, cortical surface reconstruction, gyrification index, cortical surface area, third trimester, fetal brain maturation
- MeSH terms
- Age Factors, Algorithms, Cerebral Cortex, Female, Fetus, Humans, Magnetic Resonance Imaging, Pregnancy, Fetal Development
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