Effects of neuropeptide F on regeneration in Girardia tigrina (Platyhelminthes)
Abstract
The effects of neuropeptide F (NPF; from Moniezia expansa) on the regeneration of Girardia tigrina were studied. The animals were decapitated and incubated in water (control) or NPF. The dynamics of the proliferation of the neoblasts in the developing tissue were studied during the course of regeneration by monitoring the mitotic index (MI). The effects of incubation in FMRFamide and GYIRFamide on the MI were also tested. The course of cephalic regeneration was followed with in vivo computer-assisted morphometry for up to 7 days. The development of the regenerating nervous system and the musculature was visualised by immunostaining with a primary antiserum to the C-terminal decapeptide of NPF (YFAIIGRPRFa) and tetramethylrhodamine-isothiocyanate-conjugated phalloidin, which stains F-actin in muscle filaments. The study showed that NPF had a stimulatory effect on the mitotic activity of the neoblasts. FMRFamide and GYIRFamide did not have this effect. NPF also stimulated the growth of the regenerating head and the growing nervous system and musculature. NPF is postulated to have a morphogenetic action in the regenerating animals.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The nervous system affects growth and regeneration.
“Growth and regeneration are also influenced by the nervous system [84,85].”
From An option space for early neural evolution (2015) · cites this paper as [84]
Cites
Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800 · see citing works
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254 · see citing works
STUDIES ON ANTIBODY PRODUCTION
Coons, A. H., Leduc, E. H., & Connolly, J. M. (1955) · The Journal of Experimental Medicine · doi:10.1084/jem.102.1.49 · Cited by 1,560 · see citing works
FUNDAMENTALS OF PLANARIAN REGENERATION
Reddien, P. W., & Alvarado, A. S. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.095114 · Cited by 1,108 · see citing works
Bromodeoxyuridine Specifically Labels the Regenerative Stem Cells of Planarians
Newmark, P. A., & Alvarado, A. S. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9645 · Cited by 511 · see citing works
Neuropeptide Y functions as a neuroproliferative factor
Hansel, D. E., Eipper, B. A., & Ronnett, G. V. (2001) · Nature · doi:10.1038/35073601 · Cited by 350 · see citing works
STUDIES ON ANTIBODY PRODUCTION
Ambrose, C. T., & Coons, A. H. (1963) · The Journal of Experimental Medicine · doi:10.1084/jem.117.6.1075 · Cited by 328 · see citing works
Identification of a Drosophila brain-gut peptide related to the neuropeptide Y family
Brown, M. R., CRIM, J. W., Arata, R. C., et al. (1999) · Peptides · doi:10.1016/s0196-9781(99)00097-2 · Cited by 257 · see citing works
Saló, E., & Baguñà, J. (1984) · Development · doi:10.1242/dev.83.1.63 · Cited by 234 · see citing works
Bagu��, J., & Romero, R. (1981) · Hydrobiologia · doi:10.1007/bf00026179 · Cited by 204 · see citing works
Neuropeptides and their receptors: innovative science providing novel therapeutic targets
Brain, S. D., & Cox, H. M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706461 · Cited by 195 · see citing works
The power of regeneration and the stem‐cell kingdom: freshwater planarians (Platyhelminthes)
Saló, E. (2006) · BioEssays · doi:10.1002/bies.20416 · Cited by 190 · see citing works
Maule, A. G., Shaw, C., Halton, D. W., et al. (1991) · Parasitology · doi:10.1017/s0031182000062648 · Cited by 180 · see citing works
Self-citationPlanarian Regeneration: Its End Is Its Beginning
Alvarado, A. S. (2006) · Cell · doi:10.1016/j.cell.2006.01.012 · Cited by 173 · see citing works
Baguñà, J., & Romero, R. (1981) · Springer eBooks · doi:10.1007/978-94-009-8668-8_25 · Cited by 159 · see citing works
Distribution of the stem cells (neoblasts) in the planarian Dugesia japonica
Orii, H., Sakurai, T., & Watanabe, K. (2005) · Development Genes and Evolution · doi:10.1007/s00427-004-0460-y · Cited by 151 · see citing works
Ladurner, P., Rieger, R. M., & Baguñà, J. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9867 · Cited by 144 · see citing works
Regeneration in planarians and other worms: New findings, new tools, and new perspectives
Saló, E., & Baguñà, J. (2002) · Journal of Experimental Zoology · doi:10.1002/jez.90001 · Cited by 130 · see citing works
Baguñà, J. (1976) · Journal of Experimental Zoology · doi:10.1002/jez.1401950106 · Cited by 123 · see citing works
Electron microscopic studies of planarian regeneration
Morita, M., Best, J. B., & Noel, J. (1969) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(69)90017-3 · Cited by 118 · see citing works
Flatworm nerve–muscle: structural and functional analysis
Halton, D. W., & Maule, A. G. (2004) · Canadian Journal of Zoology · doi:10.1139/z03-221 · Cited by 116 · see citing works
Self-citationRajpara, S. M., García, P. D., Roberts, R. B., et al. (1992) · Neuron · doi:10.1016/0896-6273(92)90188-j · Cited by 115 · see citing works
Baguñà, J. (1976) · Journal of Experimental Zoology · doi:10.1002/jez.1401950107 · Cited by 109 · see citing works
Led-NPF-1 stimulates ovarian development in locusts
Cerstiaensa, A. N. J. A., Benfekihb, L., Zouitenc, H., et al. (1999) · Peptides · doi:10.1016/s0196-9781(98)00152-1 · Cited by 86 · see citing works
NPY in invertebrates: molecular answers to altered functions during evolution
de Jong‐Brink, M., Maat, A. T., & Tensen, C. P. (2001) · Peptides · doi:10.1016/s0196-9781(01)00332-1 · Cited by 86 · see citing works
Baguñà, J., Saló, E., & Romero, R. (1989) · The International Journal of Developmental Biology · doi:10.1387/ijdb.2484287 · Cited by 84 · see citing works
Baguñà, J., & Slack, J. M. W. (1981) · Nature · doi:10.1038/290014b0 · Cited by 83 · see citing works
Saló, E., & Baguñà, J. (1985) · Development · doi:10.1242/dev.89.1.57 · Cited by 82 · see citing works
Parasitic peptides! The structure and function of neuropeptides in parasitic worms
Day, T. A., & Maule, A. G. (1999) · Peptides · doi:10.1016/s0196-9781(99)00093-5 · Cited by 81 · see citing works
Self-citationNeuropeptide F: Primary structure from the tubellarian, Artioposthia triangulata
Curry, W. J., Shaw, C., Johnston, C. F., et al. (1992) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(92)90272-9 · Cited by 78 · see citing works
Flatworm asexual multiplication implicates stem cells and regeneration
Reuter, M., & Kreshchenko, N. D. (2004) · Canadian Journal of Zoology · doi:10.1139/z03-219 · Cited by 73 · see citing works
Self-citationStem cells in a basal bilaterian
Gschwentner, R., Ladurner, P., Nimeth, K., & Rieger, R. M. (2001) · Cell and Tissue Research · doi:10.1007/s004410100375 · Cited by 71 · see citing works
Neuropeptide signalling systems in flatworms
McVeigh, P., Kimber, M., Novozhilova, E., & Day, T. A. (2005) · Parasitology · doi:10.1017/s0031182005008851 · Cited by 69 · see citing works
Garczynski, S. F., CRIM, J. W., & Brown, M. R. (2004) · Peptides · doi:10.1016/j.peptides.2004.07.014 · Cited by 69 · see citing works
Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts
Pedrazzini, T. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.007 · Cited by 68 · see citing works
Diapausing Colorado potato beetles are devoid of short neuropeptide F I and II
Huybrechts, J., LOOF, A. D., & Schoofs, L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.136 · Cited by 66 · see citing works
Maran, S. P. (1981) · Nature · doi:10.1038/290014a0 · Cited by 63 · see citing works
Dramatic mitotic response in planarians after feeding, and a hypothesis for the control mechanism
Baguñà, J. (1974) · Journal of Experimental Zoology · doi:10.1002/jez.1401900111 · Cited by 59 · see citing works
Gustafsson, M. K. S., Halton, D. W., Kreshchenko, N. D., Movsessian, S. O., Raikova, O. I., Reuter, M., & Борисовна, Т. Н. (2002) · Peptides · doi:10.1016/s0196-9781(02)00193-6 · Cited by 56 · see citing works
Self-citationSaló, E., & Baguñà, J. (1989) · Development · doi:10.1242/dev.107.1.69 · Cited by 54 · see citing works
Morita, M., & Best, J. B. (1984) · Journal of Experimental Zoology · doi:10.1002/jez.1402290310 · Cited by 53 · see citing works
Neuropeptides And Their Receptors
Schwartz, T. E. (1990) · Cited by 53 · see citing works
Bode, A. U. D., Salvenmoser, W., Nimeth, K., et al. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0196-2 · Cited by 49 · see citing works
Neuropeptide Y Y1 and Y2 receptor-mediated stimulation of mitogen-activated protein kinase activity
Nie, M., & SELBIE, L. A. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00070-6 · Cited by 48 · see citing works
Marks, N. J., Johnson, S. S., Maule, A. G., et al. (1996) · Parasitology · doi:10.1017/s0031182000066531 · Cited by 48 · see citing works
Self-citationNimeth, K., Mahlknecht, M., Mezzanato, A., Peter, R., Rieger, R. M., & Ladurner, P. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20035 · Cited by 47 · see citing works
A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni
Mair, G., Niciu, M., Stewart, M. T., Brennan, G., Omar, H., Halton, D., Mains, R., Eipper, B., Maule, A., & Day, T. (2004) · The FASEB Journal · doi:10.1096/fj.03-0429com · Cited by 44 · see citing works
Self-citationCytological approach to morphogenesis in the planarian blastema. II. The effect of neuropeptides.
Hori, I. (1997) · PubMed · Cited by 43 · see citing works
Reuter, M., Gustafsson, M. K. S., Sheiman, I. M., et al. (1995) · Invertebrate Neuroscience · doi:10.1007/bf02331911 · Cited by 41 · see citing works
Self-citationGschwentner, R., Ladurner, P., Nimeth, K., & Rieger, R. M. (2001) · Cell and Tissue Research · Cited by 38 · see citing works
Humphries, J. E., Kimber, M. J., Barton, Y.-W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405624200 · Cited by 38 · see citing works
The neuropeptide F (NPF) encoding gene from the cestode, Moniezia expansa
Mair, G. R., Halton, D. W., Shaw, C., et al. (2000) · Parasitology · doi:10.1017/s0031182099005296 · Cited by 38 · see citing works
Nimeth, K., Egger, B., Rieger, R. M., et al. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0299-9 · Cited by 37 · see citing works
Reuter, M., Sheiman, I. M., Gustafsson, M. K. S., et al. (1996) · Invertebrate Reproduction & Development · doi:10.1080/07924259.1996.9672514 · Cited by 34 · see citing works
Self-citationGustafsson, M. K. S. (1976) · Parasitology Research · doi:10.1007/bf02462975 · Cited by 24 · see citing works
Self-citationStimulation of mitosis in Dugesia tigrina by a neurosecretory fraction
Friedel, T., & Webb, R. A. (1979) · Canadian Journal of Zoology · doi:10.1139/z79-236 · Cited by 23 · see citing works
Dougan, P. M., Mair, G. R., Halton, D. W., et al. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10440 · Cited by 22 · see citing works
Kreshchenko, N. D., Reuter, M., Sheiman, I. M., et al. (1999) · Invertebrate Reproduction & Development · doi:10.1080/07924259.1999.9652375 · Cited by 21 · see citing works
Self-citationHrčková, G., Velebný, S., Halton, D. W., et al. (2003) · International Journal for Parasitology · doi:10.1016/j.ijpara.2003.10.007 · Cited by 20 · see citing works
Hori, I., & Kishida, Y. (2003) · PubMed · Cited by 20 · see citing works
Mahner, M., & Bunge, M. (2000) · Springer eBooks · doi:10.1007/978-3-642-57231-9_8 · Cited by 13 · see citing works
Kreshchenko, N. D., Sheiman, I. M., Reuter, M., et al. (2001) · Research Portal (Queen's University Belfast) · Cited by 7 · see citing works
Self-citation[The morphogenetic function of neuropeptides].
Sheiman, I. M., Tiras, K. P., & Ef, B. (1989) · PubMed · Cited by 4 · see citing works
Self-citationNervous System of Platyhelminthes
Professor, H. M. (2006) · Springer eBooks · doi:10.1007/3-540-29834-7_941 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
An option space for early neural evolution
Jékely, G., Keijzer, F., & Godfrey-Smith, P. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0181 · Cited by 171 · see citing works
- Authors
- Kreshchenko, N. D., Sedelnikov, Z., Sheiman, I. M., Reuter, M., Maule, A. G., & Gustafsson, M. K. S.
- Affiliations
- Institute of Cell Biophysics (RU)
- Åbo Akademi University (FI)
- Queen's University Belfast (GB)
- Corresponding author
- Gustafsson, Margaretha K. S.
- Venue
- Cell and Tissue Research
- Published
- 2007-12-20
- Volume
- 331
- Issue
- 3
- Pages
- 739-750
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W2042501003
- Cited by
- 28
- References
- 64
- Citations by year
- 2024: 1 · 2022: 2 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2013: 1 · 2012: 4
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- Wellcome Trust (069411/Z/02/Z)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- neuropeptide F, Girardia tigrina, regeneration, mitotic index, FMRFamide, nervous system regeneration, muscle regeneration, Moniezia expansa
- MeSH terms
- Actins, Amino Acids, Animals, Brain, Brain Chemistry, Colchicine, Head, Mitosis, Mitotic Index, Muscles, Nerve Regeneration, Neuropeptides, Oligopeptides, Phalloidine, Regeneration, Turbellaria, FMRFamide, Decapitation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review